Granulin (GRN) (NM_002087) Human Untagged Clone

CAT#: SC118822

GRN (untagged)-Human granulin (GRN)


  "NM_002087" in other vectors (7)

Reconstitution Protocol

USD 760.00

In Stock*

Size
    • 10 ug

Product Images

Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol GRN
Synonyms CLN11; GEP; GP88; PCDGF; PEPI; PGRN
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF within SC118822 sequence for NM_002087 edited (data generated by NextGen Sequencing)
ATGTGGACCCTGGTGAGCTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGAACGCGGTGC
CCAGATGGTCAGTTCTGCCCTGTGGCCTGCTGCCTGGACCCCGGAGGAGCCAGCTACAGC
TGCTGCCGTCCCCTTCTGGACAAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCC
TGCCAGGTTGATGCCCACTGCTCTGCCGGCCACTCCTGCATCTTTACCGTCTCAGGGACT
TCCAGTTGCTGCCCCTTCCCAGAGGCCGTGGCATGCGGGGATGGCCATCACTGCTGCCCA
CGGGGCTTCCACTGCAGTGCAGACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCC
GTGGGTGCCATCCAGTGCCCTGATAGTCAGTTCGAATGCCCGGACTTCTCCACGTGCTGT
GTTATGGTCGATGGCTCCTGGGGGTGCTGCCCCATGCCCCAGGCTTCCTGCTGTGAAGAC
AGGGTGCACTGCTGTCCGCACGGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACA
CCCACGGGCACCCACCCCCTGGCAAAGAAGCTCCCTGCCCAGAGGACTAACAGGGCAGTG
GCCTTGTCCAGCTCGGTCATGTGTCCGGACGCACGGTCCCGGTGCCCTGATGGTTCTACC
TGCTGTGAGCTGCCCAGTGGGAAGTATGGCTGCTGCCCAATGCCCAACGCCACCTGCTGC
TCCGATCACCTGCACTGCTGCCCCCAAGACACTGTGTGTGACCTGATCCAGAGTAAGTGC
CTCTCCAAGGAGAACGCTACCACGGACCTCCTCACTAAGCTGCCTGCGCACACAGTGGGG
GATGTGAAATGTGACATGGAGGTGAGCTGCCCAGATGGCTATACCTGCTGCCGTCTACAG
TCGGGGGCCTGGGGCTGCTGCCCTTTTACCCAGGCTGTGTGCTGTGAGGACCACATACAC
TGCTGTCCCGCGGGGTTTACGTGTGACACGCAGAAGGGTACCTGTGAACAGGGGCCCCAC
CAGGTGCCCTGGATGGAGAAGGCCCCAGCTCACCTCAGCCTGCCAGACCCACAAGCCTTG
AAGAGAGATGTCCCCTGTGATAATGTCAGCAGCTGTCCCTCCTCCGATACCTGCTGCCAA
CTCACGTCTGGGGAGTGGGGCTGCTGTCCAATCCCAGAGGCTGTCTGCTGCTCGGACCAC
CAGCACTGCTGCCCCCAGGGCTACACGTGTGTAGCTGAGGGGCAGTGTCAGCGAGGAAGC
GAGATCGTGGCTGGACTGGAGAAGATGCCTGCCCGCCGGGCTTCCTTATCCCACCCCAGA
GACATCGGCTGTGACCAGCACACCAGCTGCCCGGTGGGGCAGACCTGCTGCCCGAGCCTG
GGTGGGAGCTGGGCCTGCTGCCAGTTGCCCCATGCTGTGTGCTGCGAGGATCGCCAGCAC
TGCTGCCCGGCTGGCTACACCTGCAACGTGAAGGCTCGATCCTGCGAGAAGGAAGTGGTC
TCTGCCCAGCCTGCCACCTTCCTGGCCCGTAGCCCTCACGTGGGTGTGAAGGACGTGGAG
TGTGGGGAAGGACACTTCTGCCATGATAACCAGACCTGCTGCCGAGACAACCGACAGGGC
TGGGCCTGCTGTCCCTACCGCCAGGGCGTCTGTTGTGCTGATCGGCGCCACTGCTGTCCT
GCTGGCTTCCGCTGCGCAGCCAGGGGTACCAAGTGTTTGCGCAGGGAGGCCCCGCGCTGG
GACGCCCCTTTGAGGGACCCAGCCTTGAGACAGCTGCTGTGA

Clone variation with respect to NM_002087.2
>OriGene 5' read for NM_002087 unedited
TAGATTTTGTACACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGAGCGCTACCCG
GTTGCTGCTGCCCAAGGACCGCGGAGTCGGACGCAGGCAGACCATGTGGACCCTGGTGAG
CTGGGTGGCCTTAACAGCAGGGCTGGTGGCTGGAACGCGGTGCCCAGATGGTCAGTTCTG
CCCTGTGGCCTGCTGCCTGGACCCCGGAGGAGCCAGCTACAGCTGCTGCCGTCCCCTTCT
GGACAAATGGCCCACAACACTGAGCAGGCATCTGGGTGGCCCCTGCCAGGTTGATGCCCA
CTGCTCTGCCGGCCACTCCTGCATCTTTACCGTCTCAGGGACTTCCAGTTGCTGCCCCTT
CCCAGAGGCCGTGGCATGCGGGGATGGCCATCACTGCTGCCCACGGGGCTTCCACTGCAG
TGCAGACGGGCGATCCTGCTTCCAAAGATCAGGTAACAACTCCGTGGGTGCCATCCAGTG
CCCTGATAGTCAGTTCGAATGCCCGGACTTCTCCACGTGCTGTGTTATGGTCGATGGCTC
CTGGGGGTGCTGCCCCATGCCCCAGGCTTCCTGCTGTGAAGACAGGGTGCACTGCTGTCC
GCACGGTGCCTTCTGCGACCTGGTTCACACCCGCTGCATCACACCCACGGGCACCCACCC
CCTGNCAAAGAAGCTCCCTGCCCAGAGGACTAACAGGGCAGTGGCCTTGTCCAGCTCGGT
CATGTGTCCCGACGCACGGTCCCGGTGCCCTGATGGTTCTACCTGCTGTGAGCTTGCCAG
TGGGAAGTATGGCTGCTGCCCATGCCCAAACGCCACTGCTGCTCCGATCACCTGCACTGC
TGCCCCCAAGACACTGTGTGTGACCTGATCCANAGTTAGTGCCTCTCCAAGAGAACGCTA
CACCGACCTCTCACTAGCTGNCTGCCAACATGGGGGGATGTGAA
>OriGene 3' read for NM_002087 unedited
CCCCGCGCCGCCCCTCGCCCTCCCCCCTCCCCCCTCTCTTTACTTAGTACCCGGCCCGCA
TACTACGATCGGTTTTTTTTTTTTTTTTTTCGAAGTGTACAAACTTTTATTGAAACGCAC
ACGCGCACACACACAAACACCCCTGTGGTTAGGGAAAAGCACCTGCCCACAGGGTCCACT
GAAACGGGGAGGGGATGGCAGCTTGTAATGTGGCTTTTGCCACAACCCCCTTCTGACAGG
GAAGGCCTTAGATTGAGGCCCCACCTCCCATGGTGATGGGGAGCTCACAACGGTGCCCAG
CGAGACTTTGGTTAGGGCGAGGTGCTAGGGAGGCCTGAGCATAGGGCACCTCTCCGAGTG
GGGTCCCCACGCCTGCACAGTCTTCAGTACCTGCATCTCACAATACCTGTCTCAAGGCTG
GGTCCCTTAAAGGGGCGCCCCCACGCGGGGCCTCCCTGTGCACACACTAGCTCCCCCTGG
CTGCCCCGTGCCAGCCAATAAGACCAGCTGTGCTTTCCACTCGCCCAACAAACCTCCTGT
CTGTAGGCGACCACCACATCAGCCCTTGCCCCTTGTCTCCCCTCCCATTCCCGTCTATTT
ATGCCCCCACGGCCCCTGCTTTAATTCCACGCCCTTTTACACCCACTCCCGGTTCCCCGC
CCCCGAACCCCTCACGTTGTCCACACCCACTTCCTTTTCCCCAGGACCGACCCTTCCCCC
CTCCCCCCCCACCCCCCCGAACCCAACTTTTGCCACCCCCACAACCCACCTACCCGGCCC
CCTTGTCCCTATGCCCCCCTCCATCCCCACCTTCCCCCCCTATTTCACTTCACCCCCCCC
ATTTTTCTCTCCCCCCCCCCCCTTCATCTCACGCGCGCGACAAAGACACATTCTTTCCTC
CTACTCCTCCATTACCCCACCCCCCCACCCCCTTTCTTTCCCCCCTCCCGACTATAAC
Restriction Sites ECoRI-NOT     
ACCN NM_002087
Insert Size 2300 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_002087.2, NP_002078.1
RefSeq Size 2323 bp
RefSeq ORF 1782 bp
Locus ID 2896
Cytogenetics 17q21.31
Domains GRAN
Protein Families Druggable Genome, Secreted Protein
Gene Summary 'Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

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