C1R (NM_001733) Human Untagged Clone

CAT#: SC119070

C1R (untagged)-Human complement component 1, r subcomponent (C1R)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: C1R
• Synonyms: EDSPD1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119070 sequence for NM_001733 edited (data generated by NextGen Sequencing)
  ATGTGGCTCTTGTACCTCCTGGTGCCGGCCCTGTTCTGCAGGGCAGGAGGCTCCATTCCC
  ATCCCTCAGAAGTTATTTGGGGAGGTGACTTCCCCTCTGTTCCCCAAGCCTTACCCCAAC
  AACTTTGAAACAACCACTGTGATCACAGTCCCCACGGGATACAGGGTGAAGCTCGTCTTC
  CAGCAGTTTGACCTGGAGCCTTCTGAAGGCTGCTTCTATGATTATGTCAAGATCTCTGCT
  GATAAGAAAAGCCTGGGGAGGTTCTGTGGGCAACTGGGTTCTCCACTGGGCAACCCCCCG
  GGAAAGAAGGAATTTATGTCCCAAGGGAACAAGATGCTGCTGACCTTCCACACAGACTTC
  TCCAACGAGGAGAATGGGACCATCATGTTCTACAAGGGCTTCCTGGCCTACTACCAAGCT
  GTGGACCTTGATGAATGTGCTTCCCGGAGCAAATCAGGGGAGGAGGATCCCCAGCCCCAG
  TGCCAGCACCTGTGTCACAACTACGTTGGAGGCTACTTCTGTTCCTGCCGTCCAGGCTAT
  GAGCTTCAGGAAGACAGGCATTCCTGCCAGGCTGAGTGCAGCAGCGAGCTGTACACGGAG
  GCATCAGGCTACATCTCCAGCCTGGAGTACCCTCGGTCCTACCCCCCTGACCTGCGCTGC
  AACTACAGCATCCGGGTGGAGCGGGGCCTCACCCTGCACCTCAAGTTCCTGGAGCCTTTT
  GATATTGATGACCACCAGCAAGTACACTGCCCCTATGACCAGCTACAGATCTATGCCAAC
  GGGAAGAACATTGGCGAGTTCTGTGGGAAGCAAAGGCCCCCCGACCTCGACACCAGCAGC
  AATGCTGTGGATCTGCTGTTCTTCACAGATGAGTCGGGGGACAGCCGGGGCTGGAAGCTG
  CGCTACACCACCGAGATCATCAAGTGCCCCCAGCCCAAGACCCTAGACGAGTTCACCATC
  ATCCAGAACCTGCAGCCTCAGTACCAGTTCCGTGACTACTTCATTGCTACCTGCAAGCAA
  GGCTACCAGCTCATAGAGGGGAACCAGGTGCTGCATTCCTTCACAGCTGTCTGCCAGGAT
  GATGGCACGTGGCATCGTGCCATGCCCAGATGCAAGATCAAGGACTGTGGGCAGCCCCGA
  AACCTGCCTAATGGTGACTTCCGTTACACCACCACAATGGGAGTGAACACCTACAAGGCC
  CGTATCCAGTACTACTGCCATGAGCCATATTACAAGATGCAGACCAGAGCTGGCAGCAGG
  GAGTCTGAGCAAGGGGTGTACACCTGCACAGCACAGGGCATTTGGAAGAATGAACAGAAG
  GGAGAGAAGATTCCTCGGTGCTTGCCAGTGTGTGGGAAGCCCGTGAACCCCGTGGAACAG
  AGGCAGCGCATCATCGGAGGGCAAAAAGCCAAGATGGGCAACTTCCCCTGGCAGGTGTTC
  ACCAACATCCACGGGCGCGGGGGCGGGGCCCTGCTGGGCGACCGCTGGATCCTCACAGCT
  GCCCACACCCTGTATCCCAAGGAACACGAAGCGCAAAGCAACGCCTCTTTGGATGTGTTC
  CTGGGCCACACAAATGTGGAAGAGCTCATGAAGCTAGGAAATCACCCCATCCGCAGGGTC
  AGCGTCCACCCGGACTACCGTCAGGATGAGTCCTACAATTTTGAGGGGGACATCGCCCTG
  CTGGAGCTGGAAAATAGTGTCACCCTGGGTCCCAACCTCCTCCCCATCTGCCTCCCTGAC
  AACGATACCTTCTACGACCTGGGCTTGATGGGCTATGTCAGTGGCTTCGGGGTCATGGAG
  GAGAAGATTGCTCATGACCTCAGGTTTGTCCGTCTGCCCGTAGCTAATCCACAGGCCTGT
  GAGAACTGGCTCCGGGGAAAGAATAGGATGGATGTGTTCTCTCAAAACATGTTCTGTGCT
  GGACACCCATCTCTAAAGCAGGACGCCTGCCAGGGGGATAGTGGGGGCGTTTTTGCAGTA
  AGGGACCCGAACACTGATCGCTGGGTGGCCACGGGCATCGTGTCCTGGGGCATCGGGTGC
  AGCAGGGGCTATGGCTTCTACACCAAAGTGCTCAACTACGTGGACTGGATCAAGAAAGAG
  ATGGAGGAGGAGGACTGA
  
  Clone variation with respect to NM_001733.4
  455 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001733 unedited
  AATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGCACGAGAACACGGCCTTGAG
  AAATGTGGCTCTTGTACCTCCTGGTGCCGGCCCTGTTCTGCAGGGCAGGAGGCTCCATTC
  CCATCCCTCAGAAGTTATTTGGGGAGGTGACTTCCCCTCTGTTCCCCAAGCCTTACCCCA
  ACAACTTTGAAACAACCACTGTGATCACAGTCCCCACGGGATACAGGGTGAAGCTCGTCT
  TCCAGCAGTTTGACCTGGAGCCTTCTGAAGGCTGCTTCTATGATTATGTCAAGATCTCTG
  CTGATAAGAAAAGCCTGGGGAGGTTCTGTGGGCAACTGGGTTCTCCACTGGGCAACCCCC
  CGGGAAAGAAGGAATTTATGTCCCAAGGGAACAAGATGCTGCTGACCTTCCACACAGACT
  TCTCCAACGAGGAGAATGGGACCATCATGTTCTACAAGGGCTTCCTGGCCTACTACCAAG
  CTGTGGACCTTGATGAATGTGCTTCCCGGAGCAAATCAGGGGAGGAGGATCCCCAGCCCC
  AGTGCCAGCACCTGTGTCACAACTACGTTGGAGGCTACTTCTGTTCCTGCCGTCCAGGCT
  ATGAGCTTCAGGAAGACAGGCATTCCTGCCAGGCTGAGTGCAGCAGCGAGCTGTACACGG
  AGGCATCAGGCTACATCTNCAGCCTGGAGTACCCTCGGTCCTACCCCCCTGACCTGCGCT
  GCAACTACAGCATCCGGGTGGAGCGGNGCCTCACCCTGCACCTCAAGTTCCTGGAGCCTT
  TTGATATGATGACCACCANCAGTACACTGGCCCTATGACCAGCTACAGATCTATGCCAAC
  GGGAAGAACATTGGCGAGGTCTGTGGGAAGCAAAAGCGCCCCGACCTCGACACAGCAGAT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001733 unedited
  GCCGCAATTTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTGCACACTGGCATTTCTC
  ATAAAACTTTATTTGGAAAAAGTTATATTCAATGACCCAATGGTATCAAAGTGGAAGAGG
  AAAGTGACAACTAGAGATTGATAACTATATCCTCTGCAATCCTCAAAAGAAAGAAAGGGG
  CCCTTTGGGTTGTTTCAGGTAAAGTACATCAATGGGACTACAGGAAAGAGAATTTCACAC
  ACGGTCTTTCTGCATCAGTAATTTTAATAGAGACTCTTAGTGGTTATCAACAACTGGGCA
  GTTGTTTTTTGTTTTTTTTTTCCACACTGCTCTCTGGATTCGAACCTAGTGAATTCTGGG
  CTCAGTCCTCCTCCTCCATCTCTTTCTTGATCCAGTCCACGTAGTTGAGCACTTTGGTGT
  AAAAGCCATAGCCCCTGCTGCACCCGATGCCCCAGGACACGATGCCCGTGGCCACCCAGC
  GATCAGTGTTCGGGTCCCTTACTGCAAAAACGCCCCCACTATCCCCCTGGCAGGCGTCCT
  GCTTTAGAGATGGGTGTCCAGCACAGAACATGTTTTGAGAGAACACATCCATCCTATTCT
  TTCCCCGGAGCCAGTTCTCACAGGCCTGTGGATTAGCTACGGGCAGACGGACAAACCTGA
  GGTCATGAGCAATCTTCTCCTTCATGACCCCGAAGCCACTGACATAGCCCATCAAGGCCC
  AGTCGTAAAAGGTATCCTTGTCACGGAGGCAAATGGGGAAGAAGGTTGGGACCCCAGGTG
  ACACTATTTTTCCAGCTCCAGCAGGGCGATGTCCCCCTCCAAAATTGTAGACTCATCCTG
  CACGGAGTCCGGGTGGACCCTGACCCTGCGGAAGGGGGAATTCCTCACTCATGAGCCCTC
  TCCATTTGTGTGGCCAAGACCACTTCCAAAGGCGTGCTTTCCGCTCCGTTCCCTGGAAAC
  AGGGGGGGCCCTTTTAGAAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001733
• Insert Size: 2340 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001733.4, NP_001724.3
• RefSeq Size: 2526 bp
• RefSeq ORF: 2118 bp
• Locus ID: 715
• Cytogenetics: 12p13.31
• Domains: CCP, CUB, Tryp_SPc, EGF_CA, EGF
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Complement and coagulation cascades, Systemic lupus erythematosus
• Gene Summary: 'This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018]'