Lipoprotein lipase (LPL) (NM_000237) Human Untagged Clone

CAT#: SC120026

LPL (untagged)-Human lipoprotein lipase (LPL)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LPL
• Synonyms: HDLCQ11; LIPD
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC120026 sequence for NM_000237 edited (data generated by NextGen Sequencing)
  ATGGAGAGCAAAGCCCTGCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCC
  TCCCGCGGAGGGGTGGCCGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAA
  TTTGCCCTAAGGACCCCTGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTA
  GCAGAGTCCGTGGCTACCTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCAT
  GGCTGGACGGTAACAGGAATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTAC
  AAGAGAGAACCAGACTCCAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCAT
  TACCCAGTGTCCGCGGGCTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAAC
  TGGATGGAGGAGGAGTTTAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTT
  GGAGCCCATGCTGCTGGCATTGCAGGAAGTCTGACCAATAAGAAAGTCAACAGAATTACT
  GGCCTCGATCCAGCTGGACCTAACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCT
  GATGATGCAGATTTTGTAGACGTCTTACACACATTCACCAGAGGGTCCCCTGGTCGAAGC
  ATTGGAATCCAGAAACCAGTTGGGCATGTTGACATTTACCCGAATGGAGGTACTTTTCAG
  CCAGGATGTAACATTGGAGAAGCTATCCGCGTGATTGCAGAGAGAGGACTTGGAGATGTG
  GACCAGCTAGTGAAGTGCTCCCACGAGCGCTCCATTCATCTCTTCATCGACTCTCTGTTG
  AATGAAGAAAATCCAAGTAAGGCCTACAGGTGCAGTTCCAAGGAAGCCTTTGAGAAAGGG
  CTCTGCTTGAGTTGTAGAAAGAACCGCTGCAACAATCTGGGCTATGAGATCAATAAAGTC
  AGAGCCAAAAGAAGCAGCAAAATGTACCTGAAGACTCGTTCTCAGATGCCCTACAAAGTC
  TTCCATTACCAAGTAAAGATTCATTTTTCTGGGACTGAGAGTGAAACCCATACCAATCAG
  GCCTTTGAGATTTCTCTGTATGGCACCGTGGCCGAGAGTGAGAACATCCCATTCACTCTG
  CCTGAAGTTTCCACAAATAAGACATACTCCTTCCTAATTTACACAGAGGTAGATATTGGA
  GAACTACTCATGTTGAAGCTCAAATGGAAGAGTGATTCATACTTTAGCTGGTCAGACTGG
  TGGAGCAGTCCCGGCTTCGCCATTCAGAAGATCAGAGTAAAAGCAGGAGAGACTCAGAAA
  AAGGTGATCTTCTGTTCTAGGGAGAAAGTGTCTCATTTGCAGAAAGGAAAGGCACCTGCG
  GTATTTGTGAAATGCCATGACAAGTCTCTGAATAAGAAGTCAGGCTGA
  
  Clone variation with respect to NM_000237.2
  1164 c=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000237 unedited
  TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGTCCCCCTCTTCCT
  CCTCCTCAAGGGAAAGCTGCCCACTTCTAGCTGCCCTGCCATCCCCTTTAAAGGGCGACT
  TGCTCAGCGCCAAACCGCGGCTCCAGCCCTCTCCAGCCTCCGGCTCAGCCGGCTCATCAG
  TCGGTCCGCGCCTTGCAGCTCCTCCAGAGGGACGCGCCCCGAGATGGAGAGCAAAGCCCT
  GCTCGTGCTGACTCTGGCCGTGTGGCTCCAGAGTCTGACCGCCTCCCGCGGAGGGGTGGC
  CGCCGCCGACCAAAGAAGAGATTTTATCGACATCGAAAGTAAATTTGCCCTAAGGACCCG
  TGAAGACACAGCTGAGGACACTTGCCACCTCATTCCCGGAGTAGCAGAGTCCGTGGCTAC
  CTGTCATTTCAATCACAGCAGCAAAACCTTCATGGTGATCCATGGCTGGACGGTAACAGG
  AATGTATGAGAGTTGGGTGCCAAAACTTGTGGCCGCCCTGTACAAGAGAGAACCAGACTC
  CAATGTCATTGTGGTGGACTGGCTGTCACGGGCTCAGGAGCATTACCCAGTGTCCGCGGG
  CTACACCAAACTGGTGGGACAGGATGTGGCCCGGTTTATCAACTGGATGGAGGAGGAGTT
  TAACTACCCTCTGGACAATGTCCATCTCTTGGGATACAGCCTTGGAGCCCATGCTGCTGG
  CATTGCAAGAAGTCTGACCAATAAGAAAGTCAACAGAATTACTGGCCTCGATCCAGCTGG
  ACCCTACTTTGAGTATGCAGAAGCCCCGAGTCGTCTTTCTCCTGATGATGCAGATTTGGT
  AGACGTCTTACACACTTTCACCAGAGGTCCCCTGGTCGAGCATGGAATCCAGAACN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000237 unedited
  TGGACCGCGGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTGGGGGAATAA
  AATGTTGTCAATTTTATTAAAAGCTGATTCCATTTCTTCACACAGTTAAGTACGTTTCTT
  TCTTGTTTTGTTAAAGCCCATTTCATAAGATTAAGTTGGCTCTGTGAGACCATCACTGAT
  AAAGACACATACAGTTAGCACCACACATTTATAAATGCAGATAGCCACAATGACCTTTCC
  AATATGTACAAGCTCCATTTACACATCCACACATGTATTTACAGCTAATAAATAAAATGT
  AAAGCCAGAACATCCTTGATATATATAGCAAAGTTTTTCGGAGCCAGAGTTCCCAGTGCT
  ATGTGCTGCTTTAGTGAATCTTTTAAGTTAATGCACCCTGGGTCACAACCCAAATCCAGA
  AATTTAATGAATTAATAAAGGGGATGCCAACAACAAATCATACATCATTTTATTTTTAGA
  GAGAATTCATTCCAAGCCTGATGATGTTAATCACAACATTGGTCCTACTATTTATAGGCA
  CGATCATCTCTCTCAGAGAAAGGGTCGAAGTTCTGGCACATCAGGAACAATTTCTACTCC
  GACATGTTCCAATACATCCCTTGATCGACTGTTTTCCCTTCCGAATTATGCTGAAGGACA
  ACACACATGCAGAGCTTTCTAGTATGTGTTCAGATATCACATACTTTCACAGTCGGGTTC
  CCAGCTATAGCCTCTGAGAATTTGACATCTTTATCATTTCATATTTATACGTAGAAGAGC
  ATTCTGAAAAATAGGAGATCTAGNTTATAAANTAGTGGTCACTCACTCCTGATATAGTGN
  TAAAAACAAACAATTACACCCTCATGGTACTNCATCTGGCTCATTGCACGCGATGGTTTA
  CAAGCACTGCTTAGGAACCACCCCAGGAACTTTTCCACCTTN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_000237
• ORF Size: 1428 bp
• Insert Size: 3670
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_000237.1, NP_000228.1
• RefSeq Size: 3549
• RefSeq ORF: 1428
• Locus ID: 4023
• Domains: lipase, PLAT
• Protein Families: Druggable Genome
• Protein Pathways: Alzheimer's disease, Glycerolipid metabolism, PPAR signaling pathway
• Gene Summary: LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]