LARGE (NM_133642) Human Untagged Clone

CAT#: SC120425

LARGE (untagged)-Human like-glycosyltransferase (LARGE), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LARGE
• Synonyms: LARGE; MDC1D; MDDGA6; MDDGB6
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_133642, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTGGGAATCTGCAGGGGGAGACGGAAATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCCCAGCCA
  TCACCTGGATTTACCTGTTTTCTGGGAGCTTCGAAGATGGAAAGCCCGTGTCTCTGTCACCGCTGGAGTC
  CCAGGCACACAGCCCCAGGTACACGGCCTCCAGCCAGCGGGAGCGCGAGAGCCTGGAGGTGCGCATGCGC
  GAGGTGGAGGAGGAGAACCGCGCCCTCCGCAGGCAGCTCAGCCTGGCCCAGGGCCGAGCCCCATCCCATC
  GCCGAGGCAACCACTCCAAGACCTACTCCATGGAGGAGGGCACTGGAGACAGCGAGAACCTTCGGGCTGG
  CATCGTGGCAGGCAACAGCTCCGAGTGTGGGCAGCAGCCGGTCGTGGAGAAATGCGAGACAATCCACGTT
  GCTATTGTCTGCGCCGGATACAATGCCAGCCGGGATGTCGTCACCCTGGTCAAATCCGTCCTGTTCCATA
  GACGGAACCCTCTGCACTTCCACCTTATTGCTGACTCCATTGCGGAGCAGATCCTGGCCACGCTCTTCCA
  GACCTGGATGGTGCCCGCTGTGCGTGTGGACTTCTACAATGCAGACGAGCTCAAGTCTGAAGTTTCCTGG
  ATCCCCAATAAACATTACTCTGGGATTTATGGTCTGATGAAGCTTGTCCTGACCAAGACTCTTCCTGCCA
  ACCTGGAGAGAGTCATCGTCCTTGACACGGATATCACCTTTGCCACTGACATTGCAGAGCTGTGGGCTGT
  GTTCCACAAGTTCAAAGGTCAGCAAGTCCTGGGCTTGGTGGAGAACCAGAGTGACTGGTACCTTGGAAAC
  CTGTGGAAAAATCACCGCCCATGGCCAGCCCTTGGAAGAGGCTACAACACAGGGGTGATCCTGTTACTTC
  TGGATAAGCTGCGGAAGATGAAATGGGAGCAGATGTGGAGGCTGACCGCAGAGAGGGAGCTCATGGGCAT
  GCTCTCTACATCCTTAGCTGACCAGGATATTTTCAATGCCGTCATCAAACAAAACCCCTTCCTTGTGTAC
  CAGCTCCCCTGCTTCTGGAATGTGCAGCTGTCAGACCACACCCGCTCCGAGCAGTGCTACAGAGACGTGT
  CTGATCTAAAGGTCATTCACTGGAACTCCCCCAAGAAGCTCCGGGTGAAGAACAAGCATGTGGAGTTTTT
  TCGCAACCTCTACCTGACCTTCCTGGAGTATGACGGCAATCTTCTGAGGCGGGAACTGTTTGGCTGCCCC
  AGTGAGGCTGATGTCAACAGTGAAAACCTCCAGAAGCAGCTGTCTGAGCTGGACGAGGACGACCTGTGCT
  ATGAGTTCCGGCGAGAGCGCTTCACTGTCCACCGCACCCACCTGTACTTCCTGCACTACGAGTATGAGCC
  TGCAGCAGACAGCACGGACGTCACCCTGGTCGCTCAGCTGTCCATGGACAGGCTCCAGATGCTGGAGGCC
  ATCTGCAAGCACTGGGAGGGGCCCATCAGCCTGGCCCTCTACCTGTCAGACGCCGAGGCCCAGCAGTTCC
  TCCGCTACGCACAGGGCTCTGAGGTGCTTATGAGCCGCCACAACGTGGGCTACCACATCGTGTACAAGGA
  GGGCCAGTTCTACCCCGTGAACCTGCTGCGCAACGTGGCCATGAAGCACATCAGCACTCCCTACATGTTC
  CTGTCTGACATTGACTTCCTGCCCATGTATGGGCTCTATGAGTACCTCAGGAAGTCTGTCATCCAGCTCG
  ATCTTGCCAACACCAAGAAAGCAATGATTGTCCCCGCGTTCGAGACACTGCGCTACCGGCTGTCCTTCCC
  CAAGTCAAAAGCGGAGTTGCTGTCAATGCTGGACATGGGGACCCTCTTCACATTCAGGTACCACGTCTGG
  ACGAAAGGCCACGCACCCACAAACTTCGCCAAGTGGCGGACCGCCACCACGCCTTACCGGGTTGAGTGGG
  AGGCCGATTTTGAGCCGTATGTTGTTGTGAGACGTGACTGCCCGGAGTACGACCGGAGGTTTGTAGGCTT
  TGGCTGGAACAAAGTGGCTCATATCATGGAGCTGGATGTGCAGGAGTATGAGTTCATTGTGCTGCCCAAC
  GCCTACATGATCCACATGCCTCATGCCCCCAGCTTCGACATTACCAAGTTCCGTTCCAACAAGCAATACC
  GCATCTGTCTCAAAACCCTCAAGGAAGAGTTTCAGCAGGACATGTCCCGCCGCTACGGCTTTGCTGCCCT
  GAAATATCTCACAGCCGAGAACAACAGCTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_133642 unedited
  ATTAGGTATACGAACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGCAGCCCCCCCCG
  CGCCGCCGCGCTCGGCGCCCGGCCCGGCCAGTCTGCTCCTGCCCCGCCGCCGCGCCGGAG
  CCCGGGCGCCCGAAGCTGGGGGCGCGGCCGCGCTCGTCTCGCCGGGCTGTTCGCGGGCAG
  GCCCTGCCCTGAAGGGACGAATCGGCTTGGAGCGCGGGAGGTGGAGTCGGCCCCGGCGGT
  CGCTCCCTGGACCCAACCCGAGGCTGACCCAGGCCCCTGCCCATGCGGGGCGCCCCTGTC
  TCGGAAGAGTCCCCCGGGCCGGGAGCAGCTCCAGGCAGCGGCCCCGGAGGAAGAGGAAGA
  AGGGACAGTGCTCAGCTTGGGGGACCCGGACCCTCGCCGCGGCATTTGGAGCCGGGGGCA
  GTCCCGAACTCTGTGCTTGGCACCGCCGCTCCGAGTAGGGCAGCGCCTGCCGGGACTCTG
  ACCCGGACCCCCTGCGCCTCGTAGGCGGCGGCGCCGCCGCGCCACCCTGTTCTTCCGTGT
  CTCCCTCTGCCTGGCGGCAGTCACGGCCAAGAACCTACATTAAGAAACGCATTCAGATGC
  ATCAGCCGTTTGTAAAGCACCTGTCGTGAGCCAGAGAGTATTATGAGGGAGGCCGAGGAC
  TTCATGCTCCGGACAGAGAAACGGCGCTGGGATTANGGATTGCCACTTCTGAGAGGATGC
  TGGGAATCTGCAGGNGGAGACGGANATTCTTGGCTGCCTCGTTGAGTCTTCTCTGCATCC
  CAGCCATCACCTGGGATTACCTGTTTTCTGGGAGCTTCGAAGATGAAAGCCCGTGTCTCT
  GTCACCGCTGGAGTCCCCAGCCACAGGCCCAGTTACACGGCCTCCAGCCAGCGGGAGCGC
  GAGAGCCTGTAGTGCGCATGCCCCAGTTGGAGAGAAGACCGCGCCTCCGCAGCAGGTAAC
  CTGTCCAGGCCGACCCCATCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_133642 unedited
  ATCGGAGGTAAAAAAACCCCCGTCGCTTTCGCTGGTCACATCTGCACTCATACAAACAGC
  CCTTTGTAGGTAGGGCATTAACTCTTGTTCTCATCAATGTAAACACAATATTAATATTGA
  AGATTAAAGAAAATGGGTAAAAAGTCCAGTGTCTCCTCAATCTGTGTGAAGGTGAAGGTG
  GTTGCCTACCCTTGGACAGGTCCCAAAGGGAGACTGTTGTTGTCACCTCTTCCCATCCAC
  AGTGAAGCAGGCAAGAACCAGAGGAACCCAATCACTTTCTTCCTGTAGGTCTCCAGATGG
  ATACGTGAATCTTCAGAACTGGGCTTTCATGAATTATGAAAGTTCTTCGAAAGGCCTGAG
  AGGTTCGTACCTTGTGTGTGCACTGAAGTAGTTCCTTCACAGCCCTTTCCCATGAATCAG
  TCCCTGCCAATAGAAAATGTGACCGGTGTAAAACAGCCATCCCCTCGTAATTCCGCAGTC
  CCCATCGCTCTAGCCCCTGGATTCTGGAGAGTCGGGAGTTCATAGTCACGGTAGCCTCGG
  TGATCCTCCCTGACGGAAGCCTGCCCTGCTCAATTATCGGCCGAAGATGCCTTGACCTCC
  TTTCCTGAGCCACTGCTTGCTACAGGGGTGCTGCGCCCACGCAGCCTGACTCTTCCTTCT
  ATCGCCTCACAGGCACAGATCTCCCTCTCTCCGTTTTGTCACCCCCTATCGTTACCACAA
  CCTCCCTGCCATATCCTTTCTACTCTGGTGCTGCCTTTGCGGATATTGAAACCCCCTCCT
  CCCCCCCTTCCGCTCCCTCTGCGTCCACCGGCTCCTCTTGCGGTTTCTCCTCATGTTTGT
  CTAACCTCTTCGGCATGTCCTCCCTTATTATATCCCCGCTTCCATAGTGGGGCTCACGCG
  TTACCTCTCCCCCTCGCTAGGCCATTTTCCGCTTCATCTCCATGAAAAAAAAAC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_133642
• ORF Size: 2271 bp
• Insert Size: 3750
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_133642.2, NP_598397.1
• RefSeq Size: 4131
• RefSeq ORF: 2271
• Locus ID: 9215
• Domains: Glyco_transf_8
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018]
  Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.