Signal peptide peptidase like 2B (SPPL2B) (NM_020172) Human Untagged Clone

CAT#: SC120624

SPPL2B (untagged)-Human signal peptide peptidase-like 2B (SPPL2B), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SPPL2B
• Synonyms: IMP4, PSL1, KIAA1532; RGD1308556; signal peptide peptidase-like 2B
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC120624 sequence for NM_020172 edited (data generated by NextGen Sequencing)
  ATGGTGCACGTGGTCTCCCAGGCCGGGGGCCCCGAAGGCAAAGACTACTGCATCCTCTAC
  AACCCGCAGTGGGCCCATCTTCCGCACGACCTCAGCAAGGCATCTTTCCTGCAGCTGCGC
  AACTGGACGGCCTCCCTGCTCTGCTCCGCAGCCGACCTCCCCGCCCGTGGCTTCAGCAAC
  CAGATCCCGCTGGTGGCGCGGGGGAACTGCACCTTCTATGAGAAAGTGAGGCTGGCCCAG
  GGCAGCGGAGCACGCGGGCTGCTCATCGTCAGCAGGGAGAGGCTGGTCCCCCCGGGGGGT
  AATAAGACGCAGTATGATGAGATTGGCATTCCCGTGGCCCTGCTCAGCTACAAAGACATG
  CTGGACATCTTCACGCGTTTCGGCCGCACGGTGAGGGCGGCGCTGTATGCGCCTAAGGAG
  CCGGTGCTGGACTACAACATGGTCATCATCTTCATCATGGCTGTGGGCACCGTCGCCATC
  GGCGGCTACTGGGCCGGGAGTCGGGACGTGAAGAAAAGGTACATGAAGCACAAGCGCGAC
  GATGGGCCCGAGAAGCAGGAGGACGAGGCGGTGGACGTGACGCCGGTGATGACCTGCGTG
  TTTGTGGTGATGTGCTGCTCCATGCTGGTGCTGCTCTACTATTTCTACGACCTCCTCGTG
  TACGTGGTCATCGGGATCTTCTGCCTGGCCTCCGCCACCGGCCTCTACAGCTGCCTGGCG
  CCCTGTGTGCGGCGGCTGCCCTTCGGCAAGTGCAGGATCCCCAACAACAGCCTGCCCTAC
  TTCCACAAGCGCCCGCAGGCCCGTATGCTGCTCCTGGCGCTCTTCTGCGTGGCCGTCAGC
  GTGGTGTGGGGCGTCTTCCGCAACGAGGACCAGTGGGCCTGGGTCCTCCAGGATGCCCTG
  GGCATCGCCTTCTGCCTCTACATGCTGAAGACCATCCGTCTGCCCACCTTCAAGGCCTGC
  ACGCTGCTGCTGCTGGTGCTGTTCCTCTACGACATCTTCTTCGTGTTCATCACGCCCTTC
  CTGACCAAGAGTGGGAGCAGCATCATGGTGGAGGTGGCCACTGGGCCCTCGGACTCAGCC
  ACCCGTGAGAAGCTGCCCATGGTCCTGAAGGTGCCCAGGCTGAACTCCTCACCTCTGGCC
  CTGTGTGACCGGCCCTTCTCCCTCCTGGGTTTCGGAGACATTTTGGTGCCAGGGCTGCTG
  GTGGCCTACTGCCACAGGTTTGACATCCAGGTACAGTCCTCCAGGGTATACTTCGTGGCC
  TGCACCATCGCCTATGGCGTTGGCCTCCTTGTGACATTCGTGGCACTGGCCCTGATGCAG
  CGTGGCCAGCCCGCTCTCCTCTACCTGGTGCCCTGCACGCTGGTGACGAGCTGCGCTGTG
  GCGCTCTGGCGCCGGGAGCTGGGCGTGTTCTGGACGGGCAGCGGCTTTGCGAAAGTCCTA
  CCTCCATCTCCGTGGGCCCCAGCACCAGCCGACGGCCCGCAGCCTCCCAAAGACTCTGCC
  ACGCCACTCTCCCCGCAGCCGCCCAGCGAAGAACCAGCCACATCCCCCTGGCCTGCTGAG
  CAGTCCCCAAAATCACGCACGTCCGAGGAGATGGGGGCTGGAGCCCCCATGCGGGAGCCT
  GGGAGCCCAGCTGAATCCGAGGGCCGGGACCAGGCCCAGCCGTCCCCGGTAACCCAGCCT
  GGCGCCTCGGCCTAG
  
  Clone variation with respect to NM_020172.1
  651 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_020172 unedited
  TCAACATTTGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACCAAACCGGCCGA
  CATGGCGGCAGCGGTGGCGGCTGCGCTGGCGCGGCTTTTGGCGGCCTTTCTGCTCCTCGC
  GGCCCAGGTGGCCTGTGAGTACGGCATGGTGCACGTGGTCTCCCAGGCCGGGGGCCCCGA
  AGGCAAAGACTACTGCATCCTCTACAACCCGCAGTGGGCCCATCTTCCGCACGACCTCAG
  CAAGGCATCTTTCCTGCAGCTGCGCAACTGGACAGCCTCCCTGCTCTGCTCCGCAGCCGA
  CCTCCCCGCCCGTGGCTTCAGCAACCAGATCCCGCTGGTGGCGCGGGGGAACTGCACCTT
  CTATGAGAAAGTGAGGCTGGCCCAGGGCAGCGGAGCACGCGGGCTGCTCATCGTCAGCAG
  GGAGAGGCTGGTCCCCCCGGGGGGTAATAAGACGCAGTATGATGAGATTGGCATTCCCGT
  GGCCCTGCTCAGCTACAAAGACATGCTGGACATCTTCACGCGTTTCGGCCGCACGGTGAG
  GGCGGCGCTGTATGCGCCTAAGGAGCCGGTGCTGGACTACAACATGGTCATCATCTTCAT
  CATGGCTGTGGGCACCGTCGCCATCGGCGGCTACTGGGCCGGGAGTCGGGACGTGAAGAA
  AAGGTACATGAAGCACAAGCGCGACGATGGGCCCGAGAAGCANGANGACGAGGCGGTGGA
  CGTGACGCCGGTGATGACCTGCGTGTTTGTGGTGATGTGCTGCTCCATGCTGGTGCTGCT
  CTACTATTTCTACGACCTCCTCGTGTACGTGGTCATCGGGATCTTCTGCCTGGCCTCCGC
  CACCGGCCTCTACAGCTGCCTGGCGCCCTGTGTGCGGCGGCTGCCCTTCGGCAGTGCAAG
  ATCCCCAACACAGCCTGGCCTACTTCACAAGCGCCCGCAGCCCGTTGCTGCTCTGGCGCT
  N
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_020172 unedited
  NCGGCCTCTATGTACCGCGCCGCATTCTAGACTCGGTTTTTTTTTTTTTTTTTTTCTAGA
  ATTGCGACCATTTTTAAAAGGGGAGGAGTGTGCAGGCATGGCCAGGCACCTCTGGCTGAG
  GGCAGGGCAGGGCCTTAGCCAGGGGAGCAGCTTGTCCACTTACTGCCAGCCTTGTTCACG
  CCCCAAAACCCCGCCCCACGGGCCTGTCTCAGCCAGCGTCAGGGGCCAGAGGCCGCCCCG
  GCCACCGGTCCGTGTCCTAGGCTTGGAGGCAGCTTCCAAACCTCCCAGGGGCTCCGATCT
  GCTCAAGAGGGAAAAGCGATGCCTTCTGGGAGACAGAAAGCTGCTCTTCCACCCGGAGAG
  CAGGATGCCGTGGGGAGGGAGGTCACCTGAAGGCCGAAGCAGCTGGTGAGCACCAAGTGT
  GGCCGCGGCCAGAGTCCACCCACGCCTGCTCACTCATGCAGACGACGCTTGAGGGTCTGC
  AGAGAGGCCGGGCAGGGCCTGCGAGGACGGACCCCGGTGGGGAGGATGGACCCGCAGAGA
  GCTTGTGGCAGCCGGGCGAGCTGGGAGCAGCAGGCGTGCAGCCGGGGCAGCTGGGCTGGG
  CGCGGGCACAGACCGCAGGGGTCTCGGCAAGGATGATCACCATGTTGGGGCGGGTGGGGA
  CGGCACAGGCCTCGGTCCCGGGGGACAGGCGTCTGTCTGTCTGTCTCCAGTGGGCGCCAG
  GCAGCCCCAACATCTTGGTGTGGCGGGCACGGCAGCGAGCGTCTCACCCCTCCCCTAGGC
  CGATGCGCCAGGCTGGGTTACCGGGGACGGCTGGGCCTGGTCCCGGCCCTCTGATTCAGC
  TGGGCTCCAAGGCTCCCGAATGGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_020172
• ORF Size: 1815 bp
• Insert Size: 2650
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_020172.1, NP_064557.1
• RefSeq Size: 1815
• RefSeq ORF: 1815
• Locus ID: 56928
• Domains: PA, PSN, DUF435
• Protein Families: Protease, Transmembrane
• Gene Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]