DMGDH (NM_013391) Human Untagged Clone

CAT#: SC124128

DMGDH (untagged)-Human dimethylglycine dehydrogenase (DMGDH), nuclear gene encoding mitochondrial protein

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: DMGDH
• Synonyms: DMGDHD; ME2GLYDH
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_013391, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCCTGCTGCGGAGCTGCCCGCTGCAGGGCTCCCCCG
  GGCGCCCGCGCTCTGTCTGCGGCCGGGAAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAA
  AGACAGAGCAGAAACAGTGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAA
  GCAGGGATGAAAGATGTGGTCCTGCTGGAGAAATCAGAGCTCACGGCTGGATCTACCTGGCACGCAGCAG
  GTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATGATAGCATCAAACTTTATGA
  GAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAGGTAGTATCAGACTTGCTACCACC
  CCTGTAAGGGTAGATGAATTTAAATATCAAATGACTCGGACTGGCTGGCATGCAACAGAACAGTATCTCA
  TTGAACCTGAAAAAATTCAAGAGATGTTCCCTTTACTCAACATGAATAAGGTTTTAGCTGGATTGTATAA
  TCCTGGAGATGGTCACATTGATCCTTATTCTCTAACTATGGCACTGGCTGCTGGGGCTAGGAAATGTGGT
  GCCCTTTTAAAATATCCTGCACCAGTAACTTCTCTGAAAGCCAGGTCAGATGGAACATGGGACGTTGAAA
  CACCACAGGGGTCTATGAGAGCAAATAGAATTGTGAATGCTGCAGGATTTTGGGCTCGTGAAGTAGGTAA
  AATGATTGGACTAGAACATCCTCTCATTCCGGTTCAACATCAATATGTTGTTACATCGACTATATCTGAA
  GTGAAAGCTTTGAAACGAGAACTGCCTGTGCTCCGTGACCTGGAAGGATCATATTATCTCCGACAGGAAA
  GGGATGGGCTTTTGTTTGGTCCATATGAAAGTCAAGAGAAAATGAAAGTTCAGGACTCCTGGGTCACCAA
  TGGAGTTCCTCCAGGTTTTGGAAAGGAACTCTTTGAGTCTGATCTAGATCGAATCATGGAACACATCAAA
  GCTGCCATGGAAATGGTTCCTGTCTTGAAAAAGGCTGACATCATCAATGTTGTCAATGGTCCTATCACGT
  ATTCTCCTGACATTCTGCCTATGGTGGGGCCCCATCAGGGGGTCAGAAACTACTGGGTGGCTATAGGCTT
  TGGATATGGCATAATCCACGCTGGTGGGGTAGGGAAATATCTCAGTGACTGGATCCTGCATGGAGAACCT
  CCTTTTGATCTGATAGAATTGGATCCTAATCGCTATGGCAAATGGACAACAACCCAGTACACTGAGGCCA
  AAGCAAGAGAATCATATGGATTCAACAATATTGTTGGTTATCCTAAAGAAGAACGGTTTGCTGGGAGGCC
  GACTCAACGAGTCAGTGGGCTCTATCAAAGGCTGGAGTCTAAGTGTTCCATGGGGTTCCATGCTGGCTGG
  GAGCAGCCGCACTGGTTCTACAAACCAGGCCAGGACACTCAGTACAGGCCAAGTTTTCGCCGCACAAACT
  GGTTTGAGCCTGTGGGCTCGGAGTATAAACAGGTTATGCAAAGAGTAGCGGTAACTGACCTATCACCATT
  TGGCAAGTTTAACATCAAAGGCCAAGATTCCATTAGACTACTGGACCATCTCTTTGCAAATGTCATTCCA
  AAGGTGGGTTTTACAAATATAAGTCACATGTTAACACCCAAGGGTCGAGTGTATGCTGAGCTGACTGTTT
  CTCACCAATCTCCTGGGGAGTTTCTTTTAATTACTGGCTCTGGATCAGAACTTCATGATCTTAGATGGAT
  TGAAGAAGAAGCAGTCAAAGGTGGATATGATGTTGAAATTAAAAACATAACTGATGAGCTTGGAGTTCTT
  GGAGTTGCTGGGCCACAGGCAAGAAAGGTCCTTCAGAAACTGACCTCTGAAGATCTTAGTGATGATGTTT
  TCAAGTTTCTTCAAACCAAGTCCTTAAAGGTTTCCAACATTCCTGTCACTGCTATTAGGATATCTTATAC
  TGGTGAGCTGGGTTGGGAGCTGTATCACAGAAGAGAAGATTCTGTGGCGCTGTATGACGCTATCATGAAT
  GCAGGCCAGGAGGAGGGAATCGACAATTTTGGAACCTATGCCATGAATGCCTTACGCCTGGAGAAAGCCT
  TCAGAGCCTGGGGGTTAGAGATGAACTGTGATACAAATCCTTTGGAAGCTGGACTGGAATATTTTGTGAA
  GTTAAATAAGCCAGCAGACTTCATAGGAAAGCAAGCACTGAAACAGATTAAAGCCAAGGGGCTGAAACGA
  AGACTGGTCTGCCTCACCTTGGCAACGGATGATGTTGATCCAGAGGGAAATGAAAGCATCTGGTACAATG
  GCAAGGTGGTTGGCAACACGACATCTGGAAGCTATAGCTACAGCATCCAGAAGAGTCTGGCTTTCGCATA
  TGTCCCTGTACAACTAAGTGAAGTGGGACAGCAAGTGGAAGTTGAACTATTAGGCAAAAATTACCCAGCA
  GTCATCATACAAGAACCTTTGGTATTGACCGAACCAACCAGAAACCGGCTTCAGAAAAAAGGTGGAAAGG
  ACAAAACTTGA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_013391 unedited
  AGGGGATGGATTGNNCNNAATGAGTCAGCCTTTTGTAATACGCGAGAGTATAGGGCGGCC
  GCGAATTNGGCCGAGGCCTAGTCATGCTCCGTCCCGGCGCGCAGCTGCTGCGGGGCCTCC
  TGCTGCGGAGCTGCCCGCTGCAGGGCTCCCCCGGGCGCCCGCGCTCTGTCTGCGGCCGGG
  AAGGAGAGGAAAAACCACCCTTATCTGCAGAAACACAATGGAAAGACAGAGCAGAAACAG
  TGATAATTGGAGGTGGCTGTGTTGGTGTGAGTCTGGCTTATCACCTGGCCAAAGCAGGGA
  TGAAAGATGTGGTCCTGCTGGAGAAATCAGAGCTCACGGCTGGATCTACCTGGCACGCAG
  CAGGTTTAACAACTTACTTTCATCCTGGAATAAACTTGAAGAAAATACATTATGATAGCA
  TCAAACTTTATGAGAAACTGGAAGAAGAAACTGGTCAGGTGGTGGGATTCCATCAGCCAG
  GTAGTATCAGACTTGCTACCACCCCTGTGAGGGTTGATGAATTTAAATATCAAATGACTC
  GGACTGGCTGGCATGCAACAGAACAGTATCTCATTGAACCTGAAAAAATTCAAGAGATGT
  TCCCCTTACTCCACATGGATAAGGGTTTAACTTGGATGGATAATCCCTGGGATGGGCACA
  ATGATTCCCTATCTCTAACTATTGCACTTGGTGGTGGGGCTATGAAATATGGTGCGCCTT
  TTAAATATTCTGGCCACGTACTTCTTTGAAGCCAGTCAGATGGACATGGGACCTGAAACC
  CCCGGGTCTTTGAGCAAATAATTGGAGCGGC
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_013391 unedited
  TCCGGAGCGCGGAGAGGCACTGGGGAGGGGTCAAGGGATGCCACCCGGGATCTGTTCAGG
  AAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTTTTACATGTTTTTATGTAAAAAATAATTTATTAATTTGTTTTC
  AGCTGTCAAGAACCGAATGCTTTTGTTACTAAAATTATAAAATGTCCCTTAATTAGGTTA
  TAGTAATGATTGGGTATTTTAGCAAACACCTAAATGTTTTACTGATTGGGTAATGGGGGG
  TAAATAAAAAAACATTCATTTCAAATTTTTTCATTTAAAAAAACAATGGAAATCATTTAT
  CTATTATTCTGGCTTGCTTAAAAAACACTTAACAGAAAGGTTTCATTAAAATTCTAAATT
  TAAACTTTGATGATTTTGAAATGAATTCCTGGTTTCCTCTATTCCCCTGGGAGCCAGTTA
  TAATAATTTCAAGGACAGTCATTAGCAACTTTAATTCAGTTGACTGCTGAAGGTCTTTTT
  TCAAGTTTGGTCCTTTCCCCCTTTTTTTTGAACCCGGTTTCTGGTTGGTTCGGTCAATCC
  CAAAGGTTCTTGTTTGATGACTGCTGGGTAATTTTGCCTATAGTTAACTTCATTGGTGTC
  CACTTATTTATTGCCAGGCCATTTCAAAGCAACTCTTTGGATCTGACTATGCTCAAATTC
  GGTGCACACCTGCCTTGACAAGCTTAT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_013391
• ORF Size: 2601 bp
• Insert Size: 3700
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_013391.2, NP_037523.2
• RefSeq Size: 3104
• RefSeq ORF: 2601
• Locus ID: 29958
• Domains: DAO, GCV_T
• Protein Pathways: Glycine, serine and threonine metabolism, Metabolic pathways
• Gene Summary: This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.