EXDL1 (EXD1) (NM_152596) Human Untagged Clone

CAT#: SC126090

EXD1 (untagged)-Human exonuclease 3'-5' domain containing 1 (EXD1)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EXD1
• Synonyms: EXDL1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_152596 edited
  GCGTACCTTTCTCCAGGTTTTCAGCCTGTGATTTGATAACCGCCGCCGGGTGGCGTGGAG
  CGTCCCGAGACTTCTTCCTTCATTGCAGCCCCTCTTCTTTTAGTTCTAGACTGAAGTTCG
  AGGAACGCACCACTTGGCTGAAATTAGGATCCAGATTTCCCAAACTTCCTTCGGAGGAAA
  AAGCCCTAACGATGGAGGACAGTGAATTCCTAGCTTATGTGGAACTACTAGATGAAGTGG
  AACAAGGCTCAGTGAGAGCAAAAGCATCTTCTGTTAGTCTACATGCAGAAAGAACCTGGA
  TGGAGAAAATGAAAGTTGAAGACCTAAATGTATGTGAGCCTGCTTCTCCTGCCCCTGAAG
  CACCAGCTACCTCTCTGCTGAATGACCTCAAGTACAGCCCATCAGAGGAAGAGGAGGTGA
  CATACACAGTCATTAATCAATTCCAGCAGAAGTTTGGTGCTGCGATACTCCATATCAAGA
  AGCAGAATGTCCTGAGTGTGGCAGCAGAAGGAGCGAATGTATGTCGCCATGGCAAACTGT
  GCTGGCTGCAGGTGGCCACAAATTGCCGAGTTTACTTATTTGACATTTTCCTTCTGGGAA
  GTCGAGCTTTCCACAATGGACTTCAGATGATACTAGAAGACAAGAGAATTTTGAAGGTTA
  TCCATGATTGTCGTTGGCTTTCTGATTGCCTCTCTCATCAGTATGGAATTTTGCTGAATA
  ATGTCTTTGACACACAGGTAGCAGATGTACTTCAGTTTTCCATGGAAACGGGTGGCTATC
  TTCCAAACTGCATCACTACTTTGCAGGAGAGTTTAATCAAACACCTTCAAGTAGCCCCTA
  AATATCTCTCCTTTCTAGAAAAGAGACAAAAACTAATTCAGGAAAATCCAGAAGTATGGT
  TCATCCGACCTGTTTCACCCTCTTTACTGAAAATTTTGGCCCTGGAAGCTACCTACCTGT
  TACCCCTTCGCTTGGCACTCCTAGATGAGATGATGTCTGACCTAACCACCCTGGTGGATG
  GTTACCTAAACACGTATCGCGAAGGGTCTGCAGACCGGCTTGGAGGCACTGAGCCTACAT
  GTATGGAGCTGCCAGAGGAACTGCTTCAACTCAAGGACTTCCAGAAGCAGCGCAGGGAGA
  AAGCTGCAAGAGAATATAGGGTGAATGCACAGGGACTCCTGATAAGGACAGTGCTACAGC
  CAAAGAAATTAGTGACAGAGACAGCAGGGAAAGAGGAGAAAGTCAAAGGCTTCTTATTTG
  GTAAAAATTTTAGGATAGATAAAGCTCCAAGTTTTACATCTCAAGACTTTCACGGGGATG
  TGAATTTACTGAAAGAAGAATCTTTGAATAAACAAGCTACAAATCCTCAACATCTACCTC
  CCACGGAGGAAGGGGAAACTAGTGAGGATTCCAGTAACAAACTCATTTGCACAAAGTCAA
  AGGGGTCAGAGGACCAGAGAATAACTCAGAAAGAACACTTTATGACACCCAAACATGAGT
  TTCAGGCAAGTTTATCTTTGAAAGAGGAGACAGAACAGTTATTGATGGTGGAAAACAAGG
  AAGATTTAAAATGCACAAAACAGGCTGTTTCAATGTCTTCCTTTCCTCAGGAAACCAGAG
  TGTCTCCAAGTGACACTTTTTATCCTATCAGAAAGACTGTGGTTTCCACACTCCCTCCCT
  GTCCAGCCTTGGAGAAGATCGATTCCTGGATAAGTCCTTTTCTAAATCTGCCCTAGAGAT
  GGGCAGTTTGTTCTTAAGGCCATGCAGATGGCTTATTTCCTTTGCCATCAGGGCTTTCCA
  CAGTGCCCAGGTTTCTCATGTTGTAAATGTAGTAATGCTTCAGTCACAGGGGAAAATTAT
  ATCCTCTTGCTTACTCCTGTGTTCCTGGTATGCGGAGAATGAGAATGAATAAGTTAAATA
  ATGGAAGAAGTATAATTTCTGATTATGTCACTGTGTAGAAATGTTCTCAGTGACCAGAGT
  GCATTATTTTTCATAATTTGGGTTTAGAGGATTTGAAGAAAGGAAGAATCTTGGGCTTAG
  TATCAGGAAGACTCCATCATTTTCAAATTTTGTTTTGCTTCTTGACTTTTGGATTCCTTT
  GAAGAGACCTGGTAAAACTATTAACAATTCATTTAAAAAATTGGTACCTGATAACTTTAC
  CAGTACTTTTTTCCTTTTTATTTATTTGTTTTATTTATTTTTTTTTACCGCTCCTTGTGG
  AGCAGGGCTACACCATAGGCAGTGTGCCCAGAGTAACCACTTTTTTCCTTTTTAAAATAT
  AATATTAACTTTATGTTTGAATGTTGAATGTTTTGTCTGTCTCTTAGGCAAATAATGTTA
  TAGGAATCAATAATTTAATTTTTGTTTTATTTGTTTTTTGATGGAGTCTCACTCTGTCAC
  CCAGGCTGGAGTGTAGTGGTGTAATCTCTGCTCACTGCAACCTCCGCCTCCCGGGTTCAA
  GCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCGTGCCACCACGCCC
  GGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCG
  AACTCCTGACTGACCTTGTGGTCCACCTGCCTTGGCCTTCCAAAGTGCTGGGATTACAGG
  TGTGAGGCACGGTGCCCAGCCAATATCTTTATTTTAATTTGTTTTTATTTCCTTTATTTT
  TAGCTGGTTTTGTCCATTTTCCTAACAAAGCAGGGACCCTGGGTTTCTTTTTAGTCTGTC
  TGTTATATAAACTTGAAGCCTGACTCCATTCTATTTGCCTGGAGTTAGTATACTTTCTTA
  GGGTGAAAGGAAGGCAGCTTGTATTGAGCCTTTTAAAGTATTGAATGCTTGCAAATTGCT
  AACATTCTTTTGTGTAAAATAACCAATAAACCTGTTTTGTCATACTCTACTTAAAAAAAA
  AAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152596 unedited
  GGTCGGATTTGTATACGACTCATATAGGCGGCCGCATAACTTCGTATAGCATACATTATA
  CGAAGTTATGGATCAGGCCAAATCGGCCGAGCTCGAATTCGTCGAGAGCGGGCGTACCTT
  TCTCCAGGTTTTCAGCCTGTGATTTGATAACCGCCGCCGGGTGGCGTGGAGCGTCCCGAG
  ACTTCTTCCTTCATTGCAGCCCCTCTTCTTTTAGTTCTAGACTGAAGTTCGAGGAACGCA
  CCACTTGGCTGAAATTAGGATCCAGATTTCCCAAACTTCCTTCGGAGGAAAAAGCCCTAA
  CGATGGAGGACAGTGAATTCCTAGCTTATGTGGAACTACTAGATGAAGTGGAACAAGGCT
  CAGTGAGAGCAAAAGCATCTTCTGTTAGTCTACATGCAGAAAGAACCTGGATGGAGAAAA
  TGAAAGTTGAAGACCTAAATGTATGTGAGCCTGCTTCTCCTGCCCCTGAAGCACCAGCTA
  CCTCTCTGCTGAATGACCTCAAGTACAGCCCATCAGAGGAAGAGGAGGTGACATACACAG
  TCATTAATCAATTCCAGCAGAAGTTTGGTGCTGCGATACTCCATATCAAGAAGCAGAATG
  TCCTGAGTGTGGCAGCAGAAGGAGCGAATGTATGTCGCCATGGCAAACTGTGCTGGCTGC
  AGGTGGCCACAAATTGCCGAGTTTACTTATTTGACATTTTCCTTCTGGGAAGTCGAGCTT
  TCCACAATGGACTTCAGATGATACTAGAAGACAAGAGAATTTTGAAGGTTATCCATGATT
  GTCGTTTGCTTTCTGATTGCCTCTCTCATCAGTATGGAATTTTGCTGAATAATGTCTTTG
  ACACACGGTAGCANATGTACTTCAGTTTTTCATGGAAAACGGTGGCTATCTTCCAAACTG
  CATCACTACTTTGCAGGAGAGTTTAATCAACCACCTTCAGTAGCCCA
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152596
• ORF Size: 1545 bp
• Insert Size: 2900
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_152596.2, NP_689809.2
• RefSeq Size: 2949
• RefSeq ORF: 1545
• Locus ID: 161829
• Gene Summary: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.