MSL2L1 (MSL2) (NM_018133) Human Untagged Clone

CAT#: SC127078

MSL2 (untagged)-Human male-specific lethal 2 homolog (Drosophila) (MSL2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MSL2
• Synonyms: MSL-2; MSL2L1; RNF184
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127078 sequence for NM_018133 edited (data generated by NextGen Sequencing)
  ATGAACCCCGTGAATGCTACTGCTCTCTACATTTCCGCGAGCCGCCTAGTGCTCAACTAC
  GACCCCGGAGACCCCAAGGCGTTTACTGAGATTAACAGGCTCTTGCCTTACTTCCGACAG
  TCCCTTTCGTGCTGTGTTTGCGGACATTTGCTACAAGATCCTATTGCACCCACCAACTCC
  ACCTGCCAACATTATGTCTGCAAAACTTGTAAAGGCAAGAAAATGATGATGAAACCTTCC
  TGTAGCTGGTGCAAAGACTATGAGCAGTTTGAGGAAAACAAGCAGTTAAGCATCCTAGTG
  AACTGCTACAAAAAACTATGCGAGTATATAACACAGACTACACTGGCACGGGATATAATA
  GAAGCAGTTGACTGTTCTTCTGATATTTTGGCTTTGCTTAATGATGGATCATTGTTTTGT
  GAGGAGACAGAAAAACCCTCAGATTCATCCTTTACTTTGTGTTTGACACATTCCCCTTTA
  CCTTCAACCTCAGAACCCACAACTGATCCTCAAGCTAGTTTATCTCCAATGTCTGAAAGC
  ACCCTCAGCATTGCTATTGGCAGTTCTGTTATCAATGGTTTGCCTACTTATAATGGGCTT
  TCAATAGATAGATTTGGTATAAATATTCCTTCACCTGAACATTCAAATACGATTGACGTA
  TGTAATACTGTTGACATAAAAACTGAGGATCTGTCTGACAGCCTGCCACCCGTTTGTGAC
  ACAGTAGCCACTGACTTATGTTCCACAGGCATTGATATCTGCAGTTTCAGTGAAGATATA
  AAACCTGGAGACTCTCTGTTACTGAGTGTTGAGGAAGTACTCCGCAGCTTAGAAACTGTT
  TCAAATACAGAGGTCTGTTGCCCTAATTTGCAGCCGAACTTGGAAGCCACTGTATCCAAT
  GGACCTTTTCTGCAGCTTTCTTCCCAGTCTCTTAGCCATAATGTTTTTATGTCCACCAGT
  CCTGCACTTCATGGGTTATCATGTACAGCAGCAACTCCGAAGATAGCAAAATTGAATAGA
  AAACGATCCAGATCAGAGAGTGACAGTGAGAAAGTTCAGCCACTTCCAATTTCTACCATT
  ATCCGAGGCCCAACACTGGGGGCATCTGCTCCTGTGACAGTGAAACGGGAGAGCAAAATT
  TCTCTTCAACCTATAGCAACTGTTCCCAATGGAGGCACAACACCTAAAATCAGCAAAACT
  GTACTTTTATCTACTAAAAGCATGAAAAAGAGTCATGAACATGGATCCAAGAAATCTCAC
  TCTAAAACCAAGCCAGGTATTCTTAAAAAAGACAAAGCAGTAAAGGAAAAGATTCCTAGT
  CATCATTTTATGCCAGGAAGTCCTACCAAGACTGTGTACAAAAAACCCCAGGAAAAGAAA
  GGGTGTAAATGTGGGCGTGCTACTCAAAATCCAAGTGTTCTTACATGCCGAGGCCAACGC
  TGCCCTTGCTACTCTAACCGCAAAGCCTGCTTAGATTGTATATGTCGTGGCTGCCAAAAC
  TCCTATATGGCCAATGGGGAGAAGAAGCTGGAGGCATTTGCCGTGCCAGAAAAGGCCTTG
  GAGCAGACCAGGCTCACTTTGGGCATTAACGTGACTAGCATTGCTGTGCGTAACGCTAGT
  ACCAGCACCAGTGTAATAAATGTCACAGGGTCCCCAGTAACGACGTTTTTAGCTGCCAGT
  ACACATGATGATAAAAGTTTGGATGAAGCTATAGACATGAGATTCGACTGTTAA
  
  Clone variation with respect to NM_018133.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018133 unedited
  GGGGTTCACAATTGTATACGACTCATATAGGCGGCCGCGAAATTCGCACGAGGCAAACTT
  GCACGGATTTTGGTTACTTGTTTGGCCAATGGTTCGGCTCTGATTTCTTCCGAATTGTTG
  CAAATTCGCCATCGTTCCCTGGCTGCTTACTAAGTTGGATCCGGAATTTCTTTTCAACCG
  GGAGCCATTGGTGTCGAAGTGTCTGCAATGAACCCCGTGAATGCTACTGCTCTCTACATT
  TCCGCGAGCCGCCTAGTGCTCAACTACGACCCCGGAGACCCCAAGGCGTTTACTGAGATT
  AACAGGCTCTTGCCTTACTTCCGACAGTCCCTTTCGTGCTGTGTTTGCGGACATTTGCTA
  CAAGATCCTATTGCACCCACCAACTCCACCTGCCAACATTATGTCTGCAAAACTTGTAAA
  GGCAAGAAAATGATGATGAAACCTTCCTGTAGCTGGTGCAAAGACTATGAGCAGTTTGAG
  GAAAACAAGCAGTTAAGCATCCTAGTGAACTGCTACAAAAAACTATGCGAGTATATAACA
  CAGACTACACTGGCACGGGATATAATAGAAGCAGTTGACTGTTCTTCTGATATTTTGGCT
  TTGCTTAATGATGGATCATTGTTTTGTGAGGAGACAGAAAAACCCTCAGATTCATCCTTT
  ACTTTGTGTTTGACACATTCCCCTTTACCTTCAACCTCAGAACCCACAACTGATCCTCAA
  GCTAGTTTATCTCCAATGTCTGAAAGCACCCTCAGCATTGCTATTGGCAGTTCTGTTATC
  AATGGTTTGCCTACTTATAATGGGCTNTCAATAGATAGATTTGGTATAAATATTCCTTCA
  CCTGAACATTCAAATACGATTGACGTATGTAATACTGTTGACATAAAAACTNGAGATCTG
  TCTGACAGCCTGNCACCCCGTTGT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_018133 unedited
  NGGGTATTCTATGNACCGCGCCGCATTCTANGATCGATTTTTTTTTTTTTTTTTTTTTCA
  TTTTCCACCATTTACTCTTGTTATCAAAAAAGTTCAACTCTTCTTGCAAAACAAAAACAA
  AATAGTACATACTGGACACATACATCACATTTTTCTTCCTATGGCTTTAGCCCACCCCCA
  CCCCACCAAAAGAGACCAAAAAAAAAAAAAGAAAAAAAAGCCCAACAACAACAACAAAAA
  CAACTCTACCTGACCACATTCACAGAAAATGACACCAGGATACACTACAAAACAGAAGGA
  GGTGTCATCTGCTCTGTGTCCAAAGGTTTCTTCTCCATGTCTTGTACTAGGCGAGTAACC
  ATCATTGAACATGCTGTGTGCCAAATCAAAACATAACTTCAGCATATGTCAGATCTTACT
  AGAGATGGTGAACGTAGTAGAAATTGGAAATTTTCCAGCAGTATTTTTCTTTAAATAAGC
  ACTGTCAAAGCTGCAGCTCTTCTTTTAAATCACAGGTTATTTCATTACACCTAGTCAGTC
  CTTGTTTTATTTGGGCTGTGCTCTTTCAAGCAACTGACTAGATTTCCCTTCAACAGAATG
  TTTGTGACTCACTTGTCTTCCCCATAAAAATTAACCGGAAGAAGTGCATTTAAACTGAAA
  CATACTTTGTGCTTTACATGCAAAAGAGCATTCTAAAGAAAATCCTCCTAGCTTCAACCT
  ACCTAAATGCACAGGCTTTATAAAAAGGCATTNCTATTAGGCCTCTATAAAGAAGCCTTC
  ATATGAACAGCACCCTAAAAAAACTAGGAGCATATTCAAAATAAGACTGTGGCANATAAC
  TATTAGAGAAATAGTCAAGTGGCGGGCAGTGGGCATAGTACATACACAATCTGGGCAGTC
  TGGAGCATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_018133
• ORF Size: 1734 bp
• Insert Size: 4000
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_018133.2, NP_060603.2
• RefSeq Size: 4696
• RefSeq ORF: 1734
• Locus ID: 55167
• Protein Families: Druggable Genome
• Gene Summary: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longer isoform (1).