PICALM (NM_007166) Human Untagged Clone

CAT#: SC127391

PICALM (untagged)-Human phosphatidylinositol binding clathrin assembly protein (PICALM), transcript variant 1


  "NM_007166" in other vectors (6)

Reconstitution Protocol

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PICALM
Synonyms CALM; CLTH; LAP
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>NCBI ORF sequence for NM_007166, the custom clone sequence may differ by one or more nucleotides


ATGTCCGGCCAGAGCCTGACGGACCGAATCACTGCCGCCCAGCACAGTGTCACCGGCTCTGCCGTATCCA
AGACAGTATGCAAGGCCACGACCCACGAGATCATGGGGCCCAAGAAAAAGCACCTGGACTACTTAATTCA
GTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTTATTTGAAAGAACTACTAATAGT
AGTTGGGTGGTGGTCTTCAAATCTCTCATTACAACTCATCATTTGATGGTGTATGGAAATGAGCGTTTTA
TTCAGTATTTGGCTTCAAGAAACACGTTGTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGG
ATATGACATGTCTACATTTATTAGGCGGTATAGTAGATATTTAAATGAGAAAGCAGTTTCATACAGACAA
GTTGCATTTGATTTCACAAAAGTGAAGAGAGGGGCTGATGGAGTTATGAGAACAATGAACACAGAAAAAC
TCCTAAAAACTGTACCAATTATTCAGAATCAGATGGATGCACTTCTTGATTTTAATGTTAATAGCAATGA
ACTTACAAATGGGGTAATAAATGCTGCCTTCATGCTCCTGTTCAAAGATGCCATTAGACTGTTTGCAGCA
TACAATGAAGGAATTATTAATTTGTTGGAAAAATATTTTGATATGAAAAAGAACCAATGCAAAGAAGGTC
TTGACATCTATAAGAAGTTCCTAACTAGGATGACAAGAATCTCAGAGTTCCTCAAAGTTGCAGAGCAAGT
TGGAATTGACAGAGGTGATATACCAGACCTTTCACAGGCCCCTAGCAGTCTTCTTGATGCTTTGGAACAA
CATTTAGCTTCCTTGGAAGGAAAGAAAATCAAAGATTCTACAGCTGCAAGCAGGGCAACTACACTTTCCA
ATGCAGTGTCTTCCCTGGCAAGCACTGGTCTATCTCTGACCAAAGTGGATGAAAGGGAAAAGCAGGCAGC
ATTAGAGGAAGAACAGGCACGTTTGAAAGCTTTAAAGGAACAGCGCCTAAAAGAACTTGCAAAGAAACCT
CATACCTCTTTAACAACTGCAGCCTCTCCTGTATCCACCTCAGCAGGAGGGATAATGACTGCACCAGCCA
TTGACATATTTTCTACCCCTAGTTCTTCTAACAGCACATCAAAGCTGCCCAATGATCTGCTTGATTTGCA
GCAGCCAACTTTTCACCCATCTGTACATCCTATGTCAACTGCTTCTCAGGTAGCAAGTACATGGGGAGAT
CCTTTCTCTGCTACTGTAGATGCTGTTGATGATGCCATTCCAAGCTTAAATCCTTTCCTCACAAAAAGTA
GTGGTGATGTTCACCTTTCCATTTCTTCAGATGTATCTACTTTTACTACTAGGACACCTACTCATGAAAT
GTTTGTTGGATTCACTCCTTCTCCAGTTGCACAGCCACACCCTTCAGCTGGCCTTAATGTTGACTTTGAA
TCTGTGTTTGGAAATAAATCTACAAATGTTATTGTAGATTCTGGGGGCTTTGATGAACTAGGTGGACTTC
TCAAACCAACAGTGGCCTCTCAGAACCAGAACCTTCCTGTTGCCAAACTCCCACCTAGCAAGTTAGTATC
TGATGACTTGGATTCATCTTTAGCCAACCTTGTGGGCAATCTTGGCATCGGAAATGGAACCACTAAGAAT
GATGTAAATTGGAGTCAACCAGGTGAAAAGAAGTTAACTGGGGGATCTAACTGGCAACCAAAGGTTGCAC
CAACAACCGCTTGGAATGCTGCAACAATGGCACCCCCTGTAATGGCCTATCCTGCTACTACACCAACAGG
CATGATAGGATATGGAATTCCTCCACAAATGGGAAGTGTTCCTGTAATGACGCAACCAACCTTAATATAC
AGCCAGCCTGTCATGAGACCTCCAAACCCCTTTGGCCCTGTATCAGGAGCACAGATACAGTTTATGTAA


>OriGene 5' read for NM_007166 unedited
GCGGCCCGCGAATTCGCACGAGGGTGCGGTGGGGGGTGGGGACCCTCCGGCTCTTGGGGG
TCCCAGTCCCCGCCGGCTGCTGAGCGGGTGGGGTGGTGGAGGAGCTGCAGAGATGTCCGG
CCAGAGCCTGACGGACCGAATCACTGCCGCCCAGCACAGTGTCACCGGCTCTGCCGTATC
CAAGACAGTATGCAAGGCCACGACCCACGAGATCATGGGGCCCAAGAAAAAGCACCTGGA
CTACTTAATTCAGTGCACAAATGAGATGAATGTGAACATCCCACAGTTGGCAGACAGTTT
ATTTGAAAGAACTACTAATAGTAGTTGGGTGGTGGTCTTCAAATCTCTCATTACAACTCA
TCATTTGATGGTGTATGGAAATGAGCGTTTTATTCAGTATTTGGCTTCAAGAAACACGTT
GTTTAACTTAAGCAATTTTTTGGATAAAAGTGGATTGCAAGGATATGACATGTCTACATT
TATTAGGCGGTATAGTAGATATTTAAATGAGAAAGCAGTTTCATACAGACAAGTTGCATT
TGATTTCACAAAAGTGAAAAGAGGGGCTGATGGAGTTATGAGAACAATGAACACCAGAAA
ACTCCTAAAAACTGTCCCAATTATTCAGATCAAATGGATGCCCCTCCTTGGATTTTAAGT
TAAATACCAATGGAACCTACCAAAGGGGGAAAAAAAGGCTGCCCTTAAGGGCCCCTGGTA
AAAAAGGCCCTTAAAACTGGTGGGCCCTTACCAGGGAGGGGATTTTTAATTTTGTGGGAA
AAAAATTTTTGTGTTTAAAAAAAAACCCTGCCCAAAAGGGTCTCTCCCTCTTTTAAAAAT
TCCCCCCTTAGGGAAACAAA
>OriGene 3' read for NM_007166 unedited
NNNNNNNNCCCCCCCCCCCCCNNCCCCCNCCCCCCCCNNCCTTTGACTTTGGAACGCGGN
CCGCNTACTAAGATCGAGTTTTTTTTTTTTTTTTTTGGGGGAACTGCATTTTATTCTGAA
AATCCACCCATTTTGCTAACATACATTTTAATATTGTAAACAAAAATAGAATCTGCAGAG
ACAATGCAACAAGAATGCTTAAACTCATGTACAGAATTGCTTTCCTACAATGAACTGTCC
TTCTTAAGGCCCCTCTCCACCCAAATGTTAAAGATGTATTTACACAAAGCACCGATCAAC
AGTGCAGTTTAATTCTTCGTTTACTAAACTCTTGGCTAGACATTAACTTTAAAGATACTA
TTTCCCCTTATTTAAAAGGTATATGATCATAACATGGCACGAGCCAAAGAAAATGTTCAA
GGACTTTGCCCCCCTTCCCTCCCCCTTGTAACACCTTCTAGAGTTTTACTGAAAAGAAGA
AAGTCTTGAAGTGAAAGCAATTTCTCACATTCATTTGGAAAGGCCCTATGTCAAATGGAA
AAAAATGACCTGCCCAGCACAAAGCAGTAAAGACCCTTCCCAAGCCCTAATGCTGAAATT
AAAAGGAAGGGCTTTTCCTAATCAAGGAACGTTCCCTGGCAAAACCTCTAGCCAAAAATT
GCCTTATAGGTTAAAGGCCTTAAAAGGGCTCCCCCAAAACCCACAAAGGGCCGGAAATTT
TTAAAAAATTCCAACCCCTGGCCCTGGCTTTAAAAAATTAAAGGGCTCTTTTTGGAAACT
CAAAAAAAACTCTCCAAAAAAAACCCTTTTTTGGGGGAAAAAAAAAAAAAAAACGGGGGC
CATCCCCATCTCCTTTTTTTTAAAGGGGGGCCGGGAACAT
Restriction Sites NotI-NotI     
ACCN NM_007166
ORF Size 1959 bp
Insert Size 3630
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Reference Data
RefSeq NM_007166.2, NP_009097.2
RefSeq Size 3860
RefSeq ORF 1959
Locus ID 8301
Domains ENTH
Protein Families Druggable Genome
Gene Summary This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Transcript Variant: This variant (1) encodes the longest isoform (1).

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