Signal peptide peptidase like 2B (SPPL2B) (NM_152988) Human Untagged Clone

CAT#: SC127928

SPPL2B (untagged)-Human signal peptide peptidase-like 2B (SPPL2B), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SPPL2B
• Synonyms: IMP-4; IMP4; PSH4; PSL1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC127928 sequence for NM_152988 edited (data generated by NextGen Sequencing)
  ATGGCGGCAGCGGTGGCGGCTGCGCTGGCGCGGCTTTTGGCGGCCTTTCTGCTCCTCGCG
  GCCCAGGTGGCCTGTGAGTACGGCATGGTGCACGTGGTCTCCCAGGCCGGGGGCCCCGAA
  GGCAAAGACTACTGCATCCTCTACAACCCGCAGTGGGCCCATCTTCCGCACGACCTCAGC
  AAGGCATCTTTCCTGCAGCTGCGCAACTGGACGGCCTCCCTGCTCTGCTCCGCAGCCGAC
  CTCCCCGCCCGTGGCTTCAGCAACCAGATCCCGCTGGTGGCGCGGGGGAACTGCACCTTC
  TATGAGAAAGTGAGGCTGGCCCAGGGCAGCGGAGCACGCGGGCTGCTCATCGTCAGCAGG
  GAGAGGCTGGTCCCCCCGGGGGGTAATAAGACGCAGTATGATGAGATTGGCATTCCCGTG
  GCCCTGCTCAGCTACAAAGACATGCTGGACATCTTCACGCGTTTCGGCCGCACGGTGAGG
  GCGGCGCTGTATGCGCCTAAGGAGCCGGTGCTGGACTACAACATGGTCATCATCTTCATC
  ATGGCTGTGGGCACCGTCGCCATCGGCGGCTACTGGGCCGGGAGTCGGGACGTGAAGAAA
  AGGTACATGAAGCACAAGCGCGACGATGGGCCCGAGAAGCAGGAGGACGAGGCGGTGGAC
  GTGACGCCGGTGATGACCTGCGTGTTTGTGGTGATGTGCTGCTCCATGCTGGTGCTGCTC
  TACTATTTCTACGACCTCCTCGTGTACGTGGTCATCGGGATCTTCTGCCTGGCCTCCGCC
  ACCGGCCTCTACAGCTGCCTGGCGCCCTGTGTGCGGCGGCTGCCCTTCGGCAAGTGCAGG
  ATCCCCAACAACAGCCTGCCCTACTTCCACAAGCGCCCGCAGGCCCGTATGCTGCTCCTG
  GCGCTCTTCTGCGTGGCCGTCAGCGTGGTGTGGGGCGTCTTCCGCAACGAGGACCAGTGG
  GCCTGGGTCCTCCAGGATGCCCTGGGCATCGCCTTCTGCCTCTACATGCTGAAGACCATC
  CGTCTGCCCACCTTCAAGGCCTGCACGCTGCTGCTGCTGGTGCTGTTCCTCTACGACATC
  TTCTTCGTGTTCATCACGCCCTTCCTGACCAAGAGTGGGAGCAGCATCATGGTGGAGGTG
  GCCACTGGGCCCTCGGACTCAGCCACCCGTGAGAAGCTGCCCATGGTCCTGAAGGTGCCC
  AGGCTGAACTCCTCACCTCTGGCCCTGTGTGACCGGCCCTTCTCCCTCCTGGGTTTCGGA
  GACATTTTGGTGCCAGGGCTGCTGGTGGCCTACTGCCACAGGTTTGACATCCAGGTACAG
  TCCTCCAGGGTATACTTCGTGGCCTGCACCATCGCCTATGGCGTTGGCCTCCTTGTGACA
  TTCGTGGCACTGGCCCTGATGCAGCGTGGCCAGCCCGCTCTCCTCTACCTGGTGCCCTGC
  ACGCTGGTGACGAGCTGCGCTGTGGCGCTCTGGCGCCGGGAGCTGGGCGTGTTCTGGACG
  GGCAGCGGCTTTGCGAAAGTCCTACCTCCATCTCCGTGGGCCCCAGCACCAGCCGACGGC
  CCGCAGCCTCCCAAAGACTCTGCCACGCCACTCTCCCCGCAGCCGCCCAGCGAAGAACCA
  GCCACATCCCCCTGGCCTGCTGAGCAGTCCCCAAAATCACGCACGTCCGAGGAGATGGGG
  GCTGGAGCCCCCATGCGGGAGCCTGGGAGCCCAGCTGAATCAGAGGGCCGGGACCAGGCC
  CAGCCGTCCCCGGTAACCCAGCCTGGCGCCTCGGCCTAG
  
  Clone variation with respect to NM_152988.2
  735 t=>c;1722 c=>a
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_152988 unedited
  CCCCATTACCCCGCCCGTTGCCGCAAAGGGCGGCAGGCGTGTACGGTGGGAGGTCTATAT
  AAGCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGC
  CGCGAATTCGGCACGAGGCCGGCCGACATGGCGGCAGCGGTGGCGGCTTCGCTGGCGCGG
  CTTTTGGCGGCCTTTCTGCTCCTCGCGGCCCAGGTGGCCTGTGAGTACGGCATGGTGCAC
  GTGGTCTCCCAGGCCGGGGGCCCCGAAGGCAAAGACTACTGCATCCTCTACAACCCGCAG
  TGGGCCCATCTTCCGCACGACCTCAGCAAGGCATCTTTCCTGCAGCTGCGCAACTGGACG
  GCCTCCCTGCTCTGATCCGCAGCCGACCTCCCCGCCCGTGGCTTCAGCAACCAGATCCTG
  CTGGTGGCGCGGNGGAACTGCACCTTCTATGAGCAAGTGAGGCTGGCCCAGGGCAGCGNA
  GCACGCGGGCTGCTCATCGTCAGCAGGGAGAGGCTGTCCCCCCCGGGGGGTAATAGACGC
  AGCATGAGGAGATTGGCATTCCCGGGCCCTTGTTAAGTTACAAAGACCTGCTTGGACATT
  TTTACGGCGTTTCGGCCGCCCCGGGAAGGGCGGGCCTTTAATGGCCCTATAGGACCCGGG
  GGCTGGCCCACCCCCCGGGGCACCCACCTTCAAATAGGGCGTGGGGGCCCCGCCCCCATT
  TGGGGGTAAACTGGGCCCCGGGGNTCCCCCCTCTTAAAACAAGGTCCATTAAACCCCACC
  CCCCCAAATGGTCCCCCAAAAACAACAGGAACACAAGCGGGGGGAACAAAACCCCCCCGA
  AAACACCCCCTGTTTTTGGTGGAGAAAACTTCCCCCTCCCCGGNGGGGGGGATACAATAA
  TTAAAAACCCCCCCCN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_152988 unedited
  AGCCTGGGGNAGTGGGTCACAGGGNATGCCACCCGGGTTCTGTTCAGGAAAAGCTATGAC
  CGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGAAGTTGCGACCATTTATT
  AAAATGGGGAGGAGTGTGCAGGCATGGCCAGGCACCTCTGGCTGAGGGCAGGGCAGGGCC
  TTAGCCAGGGGAGCAGCTTGTCCACTTACTGCCAGCCTTGTTCACGCCCCAAAACCCCGC
  CCCACGGGCCTGTCTCAGCCAGCGTCAGGGGCCAGAGGCCGCCCCGGCCACCGGTCCGTG
  TCCTAGGCTTGGAGGCAGCTTCCAAACCTCCCAGGGGCTCCGATCTGCTCAAGAGGGAAA
  AGCGATGCCTTCTGGGAGACAGAAAGCTGCTCTTCCACCCGGAGAGCAGGATGCCGTGGG
  GAGGGAGGTCACCTGAAGGCCGAAGCAGCTGGTGAGCACCAAGTGTGGCCGCGGCCAGAG
  TCCACCCACGCCTGCTCACTCATGCAGACGACGCTTGAGGGTCTGCAGAGAGGCCGGGCA
  GGGCCTGCGAGGACGGACCCCGGTGGGGAGGATGGACCCGCAGAGAGCTTGTGGCAGCCG
  GGCGAGCTGGGAGCAGCAGGCGTGCAGCCGGNGCAGCTGGGCTGGGCGCGGGCACAGACC
  GCAGGGGTCTCGGCNAGGATGAGCACCATGTTGGGGCGGGTGGGGACGGCACAGGCCTCG
  GTCCCGGNGGACAGGCGTCTGTCTGTCTGTCTCCAGTGGGCGCCAGGCAGCCCCAAATCC
  TGGTG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_152988
• ORF Size: 1779 bp
• Insert Size: 2900
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_152988.1, NP_694533.1
• RefSeq Size: 2557
• RefSeq ORF: 1779
• Locus ID: 56928
• Protein Families: Protease, Transmembrane
• Gene Summary: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) represents the shorter transcript but encodes the longer isoform (2).