CLK2 (NM_003993) Human Untagged Clone

CAT#: SC128171

CLK2 (untagged)-Human CDC-like kinase 2 (CLK2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CLK2
• Synonyms: hCLK2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003993 edited
  AGCATTTCGTCGCCGCGGGGGTGCCGGGACTCCGGCCGCAGTGTCGCCGCCATCACGGAC
  TTCCTGTGGGACAAGCGCACGGGCCTCGCCGCCAGAACGATGCCGCATCCTCGAAGGTAC
  CACTCCTCAGAGCGAGGCAGCCGGGGGAGTTACCGTGAACACTATCGGAGCCGAAAGCAT
  AAGCGACGAAGAAGTCGCTCCTGGTCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGA
  GAGGACAGCTACCATGTCCGTTCTCGAAGCAGTTATGATGATCGTTCGTCCGACCGGAGG
  GTGTATGACCGGCGATACTGTGGCAGCTACAGACGCAACGATTATAGCCGGGATCGGGGA
  GATGCCTACTATGACACAGACTATCGGCATTCCTATGAATATCAGCGGGAGAACAGCAGT
  TACCGCAGCCAGCGCAGCAGCCGGAGGAAGCACAGACGGCGGAGGAGGCGCAGCCGGACA
  TTTAGCCGCTCATCTTCGCAGCACAGCAGCCGGAGAGCCAAGAGTGTAGAGGACGACGCT
  GAGGGCCACCTCATCTACCACGTCGGGGACTGGCTACAAGAGCGATATGAAATCGTTAGC
  ACCTTAGGAGAGGGGACCTTCGGCCGAGTTGTACAATGTGTTGACCATCGCAGGGGTGGG
  GCTCGAGTTGCCCTGAAGATCATTAAGAATGTGGAGAAGTACAAGGAAGCAGCTCGACTT
  GAGATCAACGTGCTAGAGAAAATCAATGAGAAAGACCCTGACAACAAGAACCTCTGTGTC
  CAGATGTTTGACTGGTTTGACTACCATGGCCACATGTGTATCTCCTTTGAGCTTCTGGGC
  CTTAGCACCTTCGATTTCCTCAAAGACAACAACTACCTGCCCTACCCCATCCACCAAGTG
  CGCCACATGGCCTTCCAGCTGTGCCAGGCTGTCAAGTTCCTCCATGATAACAAGCTGACA
  CATACAGACCTCAAGCCTGAAAATATTCTGTTTGTGAATTCAGACTATGAGCTCACCTAC
  AACCTAGAGAAGAAGCGAGATGAGCGCAGTGTGAAGAGCACAGCTGTGCGGGTGGTAGAC
  TTTGGCAGTGCCACCTTTGACCATGAGCACCATAGCACCATTGTCTCCACTCGCCATTAC
  CGAGCACCAGAAGTCATCCTTGAGTTGGGCTGGTCACAGCCTTGTGATGTGTGGAGTATA
  GGCTGCATCATCTTTGAATACTATGTGGGATTCACCCTCTTCCAGACCCATGACAACAGA
  GAGCATCTAGCCATGATGGAAAGGATCTTGGGTCCTATCCCTTCCCGGATGATCCGAAAG
  ACAAGAAAGCAGAAATATTTTTACCGGGGTCGCCTGGATTGGGATGAGAACACATCAGCT
  GGGCGCTATGTTCGTGAGAACTGCAAACCGCTGCGGCGGTATCTGACCTCAGAGGCAGAG
  GAACACCACCAGCTCTTCGATCTGATTGAAAGCATGCTAGAGTATGAACCAGCTAAGCGG
  CTGACCTTGGGTGAAGCCCTTCAGCATCCTTTCTTCGCCCGCCTTCGGGCTGAGCCGCCC
  AACAAGTTGTGGGACTCCAGTCGGGATATCAGTCGGTGACGATCAGGCCCTGGGCCCCCC
  TGCATCTTTTATAGCAGTGGGTGTCCAGTCCAGGACACTGGTGCTTTTTTATACAAGAGA
  ACGAGCCAGAGTTCACTCC
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003993 unedited
  ATACGACTCACTATAGGCGGCCGCGAATTCGGCACGAGGGCGGAGCGGAGAGGCCAGAGC
  CGGAGACCGAGCTGGGATCGGGCCCCGGGCGGGGGCGGTGCGAGCGGCGCCAAGCAGATC
  TTAGGGGCGGGGACGGAGCCGGGGCGGGCGGGACTGAAGCGGAGCCCGGGAACGGGGCGG
  GAGGTCCCAGGGTCCCGGGTTGGGGGGGGTGGAGCAGCATTTCGTCGCCGCGGGGGTGCC
  GGGACTCCGGCCGCAGTGTCGCCGCCATCACGGACTTCCTGTGGGACAAGCGCACGGGCC
  TCGCCGCCAGAACGATGCCGCATCCTCGAAGGTACCACTCCTCAGAGCGAGGCANGCCGG
  GGGAGTTACCGTGAACACTATCGGAGCCGAAAGCATAAGCGACGAAGAAGTCGCTCCTGG
  TCAAGTAGTAGTGACCGGACACGACGGCGTCGGCGAGAGGACAGCTACCATGTCCGTTCT
  GNAAGCAGTTATGATTGATCGTTCGTCCGCCGGGGAGGGTGTATGACCGGCGATACTGTG
  GCAGNCTACAGACGCACGATATAGCCGGGGATCGGGGAGATGCCTACTATGACACAGACT
  ATCGGCATTCCTATGAATTTCAGGGGGGGAACAGGAAGTTCCGGAACCAGGGCAAAACCG
  GGGGGGACCCCAAAGGGGGAGGGGGGCACCCGGAATTTTACCTTTTTTTTTCCACCAAAA
  CCGGGGACCAAGGTTTAAAGGGCACCTTTGGGCCCCTTTTTCCCCGGGGGGGGCGGTTTC
  CAGAGGATTTAAAACTGCCCCTTTTGGAAGGGGGTCTTCCCGGTGTTCAATGGTGGCCCC
  CGGGGGGGGGGGGGGCNNCCCCCCAAAAAAAAAAAGGGGGGAAAACACACGCACCC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_003993
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003993.2, NP_003984.2
• RefSeq Size: 2175 bp
• RefSeq ORF: 1497 bp
• Locus ID: 1196
• Cytogenetics: 1q22
• Domains: pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase
• Gene Summary: 'This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]'
  Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.