CES2 (NM_003869) Human Untagged Clone

CAT#: SC128182

CES2 (untagged)-Human carboxylesterase 2 (CES2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CES2
• Synonyms: CE-2; CES2A1; iCE; PCE-2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC128182 sequence for NM_003869 edited (data generated by NextGen Sequencing)
  ATGACTGCTCAGTCCCGCTCTCCTACCACACCCACCTTTCCCGGCCCAAGCCAGCGCACC
  CCGCTGACTCCCTGCCCAGTCCAAACTCCAAGGCTGGGCAAGGCACTGATCCACTGCTGG
  ACAGACCCGGGGCAGCCTCTGGGTGAACAGCAGCGTGTCCGCCGGCAGCGAACCGAGACC
  AGCGAGCCGACCATGCGGCTGCACAGACTTCGTGCGCGGCTGAGCGCGGTGGCCTGTGGG
  CTTCTGCTGCTTCTTGTCCGGGGCCAGGGCCAGGACTCAGCCAGTCCCATCCGGACCACA
  CACACGGGGCAGGTGCTGGGGAGTCTTGTCCATGTGAAGGGCGCCAATGCCGGGGTCCAA
  ACCTTCCTGGGAATTCCATTTGCCAAGCCACCTCTAGGTCCGCTGCGATTTGCACCCCCT
  GAGCCCCCTGAATCTTGGAGTGGTGTGAGGGATGGAACCACCCATCCGGCCATGTGTCTA
  CAGGACCTCACCGCAGTGGAGTCAGAGTTTCTTAGCCAGTTCAACATGACCTTCCCTTCC
  GACTCCATGTCTGAGGACTGCCTGTACCTCAGCATCTACACGCCGGCCCATAGCCATGAA
  GGCTCTAACCTGCCGGTGATGGTGTGGATCCACGGTGGTGCGCTTGTTTTTGGCATGGCT
  TCCTTGTATGATGGTTCCATGCTGGCTGCCTTGGAGAACGTGGTGGTGGTCATCATCCAG
  TACCGCCTGGGTGTCCTGGGCTTCTTCAGCACTGGAGACAAGCACGCAACCGGCAACTGG
  GGCTACCTGGACCAAGTGGCTGCACTACGCTGGGTCCAGCAGAATATCGCCCACTTTGGA
  GGCAACCCTGACCGTGTCACCATTTTTGGCGAGTCTGCGGGTGGCACGAGTGTGTCTTCG
  CTTGTTGTGTCCCCCATATCCCAAGGACTCTTCCACGGAGCCATCATGGAGAGTGGCGTG
  GCCCTCCTGCCCGGCCTCATTGCCAGCTCAGCTGATGTCATCTCCACGGTGGTGGCCAAC
  CTGTCTGCCTGTGACCAAGTTGACTCTGAGGCCCTGGTGGGCTGCCTGCGGGGCAAGAGT
  AAAGAGGAGATTCTTGCAATTAACAAGCCTTTCAAGATGATCCCCGGAGTGGTGGATGGG
  GTCTTCCTGCCCAGGCACCCCCAGGAGCTGCTGGCCTCTGCCGACTTTCAGCCTGTCCCT
  AGCATTGTTGGTGTCAACAACAATGAATTCGGCTGGCTCATCCCCAAGGTCATGAGGATC
  TATGATACCCAGAAGGAAATGGACAGAGAGGCCTCCCAGGCTGCTCTGCAGAAAATGTTA
  ACGCTGCTGATGTTGCCTCCTACATTTGGTGACCTGCTGAGGGAGGAGTACATTGGGGAC
  AATGGGGATCCCCAGACCCTCCAAGCGCAGTTCCAGGAGATGATGGCGGACTCCATGTTT
  GTGATCCCTGCACTCCAAGTAGCACATTTTCAGTGTTCCCGGGCCCCTGTGTACTTCTAC
  GAGTTCCAGCATCAGCCCAGCTGGCTCAAGAACATCAGGCCACCGCACATGAAGGCAGAC
  CATGGTGATGAGCTTCCTTTTGTTTTCAGAAGTTTCTTTGGGGGCAACTACATTAAATTC
  ACTGAGGAAGAGGAGCAGCTAAGCAGGAAGATGATGAAGTACTGGGCCAACTTTGCGAGA
  AATGGGAACCCCAATGGCGAGGGTCTGCCACACTGGCCGCTGTTCGACCAGGAGGAGCAA
  TACCTGCAGCTGAACCTACAGCCTGCGGTGGGCCGGGCTCTGAAGGCCCACAGGCTCCAG
  TTCTGGAAGAAGGCGCTGCCCCAAAAGATCCAGGAGCTCGAGGAGCCTGAAGAGAGACAC
  ACAGAGCTGTAG
  
  Clone variation with respect to NM_003869.5
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003869 unedited
  TTTAGGCTCCATTTGTATACCACTTACTATAGGCGGCCGCGNATTCANATCCACAAGTTT
  GTACAAAAAAGCAGCTTGTAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAG
  GCCTGGGTGGCGAATTCGGCACGAGGGTCGCGCGAGGGACACGCCGCGTTGTGGGTTCTC
  GGCCTGAGGTGCGAGAGAAGCGGTGACCGCGGCCCTGGCTGCTCGGACCCGGGAACATGA
  TGGTCGCTGGAGCAGAAGGCGCTGAGAAGGGACCACGGCGGCGCTGGGTCGTGCGAGCCA
  GTAGCGGGCTGAAACGTAGAGGCCAGAACCAGGTCTCAGGGGGCACTAAAGGCGGTCGGA
  GGTAATCCCCACACCGCTTCCTCCTGGAAGTCAGGCTGGCCGGGAGCTCCCGTATCCAGG
  ACGGTTGGTCGCCTCTGGCCTGGCAGGGATCCTAGTGTCTCGGGACCTCCCGGTGACGCG
  CCTGCCTCCCCTGCTGCACCATAGGCCCCGGGAGTACGGCGTCCCCCACAGCTTGAACCG
  GCGGGGGCTCGTGAAATGTTGTGCAGGGGGATAATTGACCATGGCCGTGGTCTTCGCGGG
  AGGTGAGGAAACTTGAAGCCACCCGTGAAAAGGGGGGCCCTCCTTTAGAAATGCCCGCGT
  CACCTGTCCCTTTCAAAAAATGGCCGTGCCTTGATAGGGAGGGGACCGCGGGAAACCTTT
  ACCCCCCTCTACTTTTAAAGAAAATTAGGGCCCCCTTAAGGGGTAACCCCGGGAAACTGG
  GTCCTCTGCAACAGAAGGGGGAATCTTCCCAATTTGAGGGGGGCCGAAACCTCCTTTCCT
  GCCTTTTGTAAGAGGGGTTCTCTTTCCCCCAATCAAATGCTTCTCCCACTTTCTCCCTTT
  CGGGGTGATTCCCTAACCCG
  
• Restriction Sites: Please inquire
• ACCN: NM_003869
• ORF Size: 1872 bp
• Insert Size: 3200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).

Reference Data

• RefSeq: NM_003869.4, NP_003860.2
• RefSeq Size: 3957
• RefSeq ORF: 1872
• Locus ID: 8824
• Domains: COesterase
• Protein Families: Druggable Genome
• Protein Pathways: Drug metabolism - other enzymes
• Gene Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
  Transcript Variant: This variant (1) encodes the longest isoform (1) and contains a longer 5' UTR than some of the other variants. This variant represent use of an alternate promote that is used in some tissues, and uses a downstream start codon. The upstream start codon is not well conserved. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is more supported by available conservation data.