PDE3A (NM_000921) Human Untagged Clone

CAT#: SC300151

PDE3A (untagged)-Human phosphodiesterase 3A, cGMP-inhibited (PDE3A)


  "NM_000921" in other vectors (6)

Reconstitution Protocol

USD 1,100.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PDE3A
Synonyms CGI-PDE; CGI-PDE-A; CGI-PDE A; HTNB
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_000921 edited
GGGGGCCACTGGGAATTCAGTGAAGAGGGCACCCTATACCATGGCAGTGCCCGGCGACGC
TGCACGAGTCAGGGACAAGCCCGTCCACAGTGGGGTGAGTCAAGCCCCCACGGCGGGCCG
GGACTGCCACCATCGTGCGGACCCCGCATCGCCGCGGGACTCGGGCTGCCGTGGCTGCTG
GGGAGACCTGGTGCTGCAGCCGCTCCGGAGCTCTCGGAAACTTTCCTCCGCGCTGTGCGC
GGGCTCCCTGTCCTTTCTGCTGGCGCTGCTGGTGAGGCTGGTCCGCGGGGAGGTCGGCTG
TGACCTGGAGCAGTGTAAGGAGGCGGCGGCGGCGGAGGAGGAGGAAGCAGCCCCGGGAGC
AGAAGGGGGCGTCTTCCCGGGGCCTCGGGGAGGTGCTCCCGGGGGCGGTGCGCGGCTCAG
CCCCTGGCTGCAGCCCTCGGCGCTGCTCTTCAGTCTCCTGTGTGCCTTCTTCTGGATGGG
CTTGTACCTCCTGCGCGCCGGGGTGCGCCTGCCTCTGGCTGTCGCGCTGCTGGCCGCCTG
CTGCGGGGGGGAAGCGCTCGTCCAGATTGGGCTGGGCGTCGGGGAGGATCACTTACTCTC
ACTCCCCGCCGCGGGGGTGGTGCTCAGCTGCTTGGCCGCCGCGACATGGCTGGTGCTGAG
GCTGAGGCTGGGCGTCCTCATGATCGCCTTGACTAGCGCGGTCAGGACCGTGTCCCTCAT
TTCCTTAGAGAGGTTCAAGGTCGCCTGGAGACCTTACCTGGCGTACCTGGCCGGCGTGCT
GGGGATCCTCTTGGCCAGGTACGTGGAACAAATCTTGCCGCAGTCCGCGGAGGCGGCTCC
AAGGGAGCATTTGGGGTCCCAGCTGATTGCTGGGACCAAGGAAGATATCCCGGTGTTTAA
GAGGAGGAGGCGGTCCAGCTCCGTCGTGTCCGCCGAGATGTCCGGCTGCAGCAGCAAGTC
CCATCGGAGGACCTCCCTGCCCTGTATACCGAGGGAACAGCTCATGGGGCATTCAGAATG
GGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACAT
CGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCC
ACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTT
CCAGGCCATTCACAAGCCCAGAGTGAATCCCGTTACTTCGCTCAGTGAAAACTATACCTG
TTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAG
GAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGC
CACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAA
ACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCT
CACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGC
TAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTC
CTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTT
TCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTA
CACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAG
CTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGT
AGCCACTCGGACACCAAGTAGAACAGATGACACTGCTCAAGTTACCTCTGATTATGAAAC
CAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAG
AGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCT
GGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGA
GCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATG
TGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTGTTTGAAGC
TTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAG
GGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCT
TACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGA
TTCAGATTCTGACAGTGGATTTACACATGGACATATGGGATATGTATTCTCAAAAACGTA
TAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGAT
GGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACTAATGCTTT
CCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAA
TCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAAT
TAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGC
CACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGA
TGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAA
GTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGG
TATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAG
CCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCA
CATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGT
GGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACC
AGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAA
AAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAA
GAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGAC
CCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGG
GAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATG
GGCTGTGTTTCCAAACAGATTGACTTGTCAAAGACTCTCTTCAAGCCAGCACAAGCA
Restriction Sites Please inquire     
ACCN NM_000921
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000921.3, NP_000912.3
RefSeq Size 4124 bp
RefSeq ORF 3426 bp
Locus ID 5139
Cytogenetics 12p12.2
Protein Families Druggable Genome, Transmembrane
Protein Pathways Insulin signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism
Gene Summary 'This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]'
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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