TrkC (NTRK3) (NM_001012338) Human Untagged Clone

CAT#: SC301636

NTRK3 (untagged)-Human neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NTRK3
• Synonyms: gp145(trkC); GP145-TrkC; TRKC
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_001012338 edited
  ATGGATGTCTCTCTTTGCCCAGCCAAGTGTAGTTTCTGGCGGATTTTCTTGCTGGGAAGC
  GTCTGGCTGGACTATGTGGGCTCCGTGCTGGCTTGCCCTGCAAATTGTGTCTGCAGCAAG
  ACTGAGATCAATTGCCGGCGGCCGGACGATGGGAACCTCTTCCCCCTCCTGGAAGGGCAG
  GATTCAGGGAACAGCAATGGGAACGCCAGTATCAACATCACGGACATCTCAAGGAATATC
  ACTTCCATACACATAGAGAACTGGCGCAGTCTTCACACGCTCAACGCCGTGGACATGGAG
  CTCTACACCGGACTTCAAAAGCTGACCATCAAGAACTCAGGACTTCGGAGCATTCAGCCC
  AGAGCCTTTGCCAAGAACCCCCATTTGCGTTATATAAACCTGTCAAGTAACCGGCTCACC
  ACACTCTCGTGGCAGCTCTTCCAGACGCTGAGTCTTCGGGAATTGCAGTTGGAGCAGAAC
  TTTTTCAACTGCAGCTGTGACATCCGCTGGATGCAGCTCTGGCAGGAGCAGGGGGAGGCC
  AAGCTCAACAGCCAGAACCTCTACTGCATCAACGCTGATGGCTCCCAGCTTCCTCTCTTC
  CGCATGAACATCAGTCAGTGTGACCTTCCTGAGATCAGCGTGAGCCACGTCAACCTGACC
  GTACGAGAGGGTGACAATGCTGTTATCACTTGCAATGGCTCTGGATCACCCCTTCCTGAT
  GTGGACTGGATAGTCACTGGGCTGCAGTCCATCAACACTCACCAGACCAATCTGAACTGG
  ACCAATGTTCATGCCATCAACTTGACGCTGGTGAATGTGACGAGTGAGGACAATGGCTTC
  ACCCTGACGTGCATTGCAGAGAACGTGGTGGGCATGAGCAATGCCAGTGTTGCCCTCACT
  GTCTACTATCCCCCACGTGTGGTGAGCCTGGAGGAGCCTGAGCTGCGCCTGGAGCACTGC
  ATCGAGTTTGTGGTGCGTGGCAACCCCCCACCAACGCTGCACTGGCTGCACAATGGGCAG
  CCTCTGCGGGAGTCCAAGATCATCCATGTGGAATACTACCAAGAGGGAGAGATTTCCGAG
  GGCTGCCTGCTCTTCAACAAGCCCACCCACTACAACAATGGCAACTATACCCTCATTGCC
  AAAAACCCACTGGGCACAGCCAACCAGACCATCAATGGCCACTTCCTCAAGGAGCCCTTT
  CCAGAGAGCACGGATAACTTTATCTTGTTTGACGAAGTGAGTCCCACACCTCCTATCACT
  GTGACCCACAAACCAGAAGAAGACACTTTTGGGGTATCCATAGCAGTTGGACTTGCTGCT
  TTTGCCTGTGTCCTGTTGGTGGTTCTCTTCGTCATGATCAACAAATATGGTCGACGGTCC
  AAATTTGGAATGAAGGGTCCCGTGGCTGTCATCAGTGGTGAGGAGGACTCAGCCAGCCCA
  CTGCACCACATCAACCACGGCATCACCACGCCCTCGTCACTGGATGCGGGGCCCGACACT
  GTGGTCATTGGCATGACTCGCATCCCTGTCATTGAGAACCCCCAGTACTTCCGTCAGGGA
  CACAACTGCCACAAGCCGGACACGTATGTGCAGCACATTAAGAGGAGAGACATCGTGCTG
  AAGCGAGAACTGGGTGAGGGAGCCTTTGGAAAGGTCTTCCTGGCCGAGTGCTACAACCTC
  AGCCCGACCAAGGACAAGATGCTTGTGGCTGTGAAGGCCCTGAAGGATCCCACCCTGGCT
  GCCCGGAAGGATTTCCAGAGGGAGGCCGAGCTGCTCACCAACCTGCAGCATGAGCACATT
  GTCAAGTTCTATGGAGTGTGCGGCGATGGGGACCCCCTCATCATGGTCTTTGAATACATG
  AAGCATGGAGACCTGAATAAGTTCCTCAGGGCCCATGGGCCAGATGCAATGATCCTTGTG
  GATGGACAGCCACGCCAGGCCAAGGGTGAGCTGGGGCTCTCCCAAATGCTCCACATTGCC
  AGTCAGATCGCCTCGGGTATGGTGTACCTGGCCTCCCAGCACTTTGTGCACCGAGACCTG
  GCCACCAGGAACTGCCTGGTTGGAGCGAATCTGCTAGTGAAGATTGGGGACTTCGGCATG
  TCCAGAGATGTCTACAGCACGGATTATTACAGGCTCTTTAATCCATCTGGAAATGATTTT
  TGTATATGGTGTGAGGTGGGAGGACACACCATGCTCCCCATTCGCTGGATGCCTCCTGAA
  AGCATCATGTACCGGAAGTTCACTACAGAGAGTGATGTATGGAGCTTCGGGGTGATCCTC
  TGGGAGATCTTCACCTATGGAAAGCAGCCATGGTTCCAACTCTCAAACACGGAGGTCATT
  GAGTGCATTACCCAAGGTCGTGTTTTGGAGCGGCCCCGAGTCTGCCCCAAAGAGGTGTAC
  GATGTCATGCTGGGGTGCTGGCAGAGGGAACCACAGCAGCGGTTGAACATCAAGGAGATC
  TACAAAATCCTCCATGCTTTGGGGAAGGCCACCCCAATCTACCTGGACATTCTTGGCTAG
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001012338 unedited
  CTATAGGGCGGCCGCGAATTCGGCACGAGGCCTCGTGCCGAATTCGGCACGAGGCTCCTC
  TCCTCCTCCTCTTTTTTAGAAGCAGCGATCGGAGATGGATGTCTCTCTTTGCCCAGCCAA
  GTGTAGTTTCTGGCGGATTTTCTTGCTGGGAAGCGTCTGGCTGGACTATGTGGGCTCCGT
  GCTGGCTTGCCCTGCAAATTGTGTCTGCAGCAAGACTGAGATCAATTGCCGGCGGCCGGA
  CGATGGGAACCTCTTCCCCCTCCTGGAAGGGCAGGATTCAGGGAACAGCAATGGGAACGC
  CAGTATCAACATCACGGACATCTCAAGGAATATCACTTCCATACACATAGAGAACTGGCG
  CAGTCTTCACACGCTCAACGCCGTGGACATGGAGCTCTACACCGGACTTCAAAAGCTGAC
  CATCAAGAACTCAGGACTTCGGAGCATTCAGCCCAGAGCCTTTGCCAAGAACCCCCATTT
  GCGTTATATAAACCTGTCAAGTAACCGGCTCACCACACTCTCGTGGCAGCTCTTCCAGAC
  GCTGAGTCTTCGGGAATTGCAGTTGGAGCAGAACTTTNTCAACTGCAGCTGTGACATCCG
  CTGGATGCAGCTCTGGCAGGAGCAGGGGGAGGCCAAGCTCACAGCCAGAACCTCTACTGC
  ATCAACGCTGATGGCTNCCAGCTTNCTCTCTTTCGCATGAACATCAGTCAGTGTGACCTT
  CCTGAGATCAGCGTGAGCCACGTCACCNTGACCGTACGAGAGGGTGACAATGCTGNTATC
  ACTTGCATGGGCTCTGGATCACCCCTTNNCTGATGTGACTGGATAGTCACTGGGCTGCAG
  TCATCAACACTCACCAGACAATCTGACTGGACCATGNTCATGCCCATCACTGAGCTGNTG
  AATGTGACAAGTGAGACATGGGCTACCCCTGACTGCATGANAAAACGTGTGGCATGACAT
  GCANTGTTGCCTACTGCACATTCCCCACTTGTAGCCTGAGAACTGACTGCCCTGACTGAT
  TNATTTGGGG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001012338 unedited
  NNNNTTTTACTCTGAACCCGCGGCCGCATNCTAGGATCGAGTTTTTTTTTTTTTTTTTTC
  CTTTTTTCAGTGTTGTATGTGTAGCAGGCACTTGAGTTTATATGAAGATGTTCGCTTCAG
  TCAAGGATGGAAGGAGTTGTGAGGTGGAAGGGAGATGTGAGGCAGGGAGAGAGGAGGCAA
  CAGAGTATGAATTCATGACCACCAGCCACCACTAGCCAAGAATGTCCAGGTAGATTGGGG
  TGGCCTTCCCCAAAGCATGGAGGATTTTGTAGATCTCCTTGATGTTCAACCGCTGCTGTG
  GTTCCCTCTGCCAGCACCCCAGCATGACATCGTACACCTCTTTGGGGCAGACTCGGGGCC
  GCTCCAAAACACGACCTTGGGTAATGCACTCAATGACCTCCGTGTTTGAGAGTTGGAACC
  ATGGCTGCTTTCCATAGGTGAAGATCTCCCAGAGGATCACCCCGAAGCTCCATACATCAC
  TCTCTGTAGTGAACTTCCGGTACATGATGCTTTCAGGAGGCATCCAGCGAATGGGGAGCA
  TGGTGTGTCCTCCCACCTCACACCATATACAAAAATCATTTCCAGATGGATTAAAGAGCC
  TGNTATAATCCGTGCTGTAGACATCTCTGGACATGCCGAAGTCCCCAATCTTCACTAGCA
  GATTCGCTCCAACCAGGCAGTTCCTGGTGGGGCCAGTCTCGTGCACAAAGTGCTGGGAGG
  CCANGTACACCATACCCNGAGCGATCTGACTGGCATGTGNAGCATTTGGGAGAGCCCAGC
  TCACCCTGGGCCTGNCGTGGCTGTCCATCCACAGGNATCATTGCATCTGGCCCATGGNCC
  CNTGAGAAACTATCANGCCTNCATGCTNCATGTATTCAAAGACATGATAAGGGGGTCCCC
  ATCGCCGCCACTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001012338
• Insert Size: 2710 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001012338.1, NP_001012338.1
• RefSeq Size: 3004 bp
• RefSeq ORF: 2520 bp
• Locus ID: 4916
• Cytogenetics: 15q25.3
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Neurotrophin signaling pathway
• Gene Summary: 'This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]'
  Transcript Variant: This variant (1) encodes the longest isoform (a).