UNC45B (NM_001033576) Human Untagged Clone

CAT#: SC302743

UNC45B (untagged)-Human unc-45 homolog B (C. elegans) (UNC45B), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UNC45B
• Synonyms: CMYA4; CTRCT43; SMUNC45; UNC-45B; UNC45
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001033576, the custom clone sequence may differ by one or more nucleotides
  ATGGCAGAGGTGGAAGCGGTACAGCTGAAGGAGGAAGGAAACCGGCATTTCCAGCTCCAG
  GACTACAAGGCCGCCACAAATAGCTACAGCCAGGCCCTGAAGCTGACCAAGGACAAGGCC
  CTGCTGGCCACGCTTTATCGGAACCGGGCAGCCTGTGGCCTGAAAACGGAGAGCTACGTC
  CAGGCAGCTTCAGATGCCTCCAGAGCCATCGACATCAACTCCTCGGACATCAAGGCTCTG
  TATCGGCGATGCCAGGCACTGGAGCACCTGGGGAAGCTGGACCAGGCCTTCAAAGACGTG
  CAGCGTTGTGCCACCCTCGAGCCACGGAACCAGAACTTCCAGGAGATGCTGAGGAGACTC
  AACACCAGCATTCAGGAGAAGCTCCGAGTGCAGTTCTCCACAGACTCGAGGGTACAGAAG
  ATGTTTGAGATCCTCTTGGATGAAAACAGTGAGGCTGATAAGCGGGAAAAGGCTGCCAAC
  AATCTCATTGTCCTAGGCCGTGAGGAAGCAGGGGCTGAGAAGATCTTCCAGAACAATGGA
  GTAGCCTTGCTACTGCAGCTTCTGGACACTAAGAAGCCTGAGCTGGTGCTGGCTGCAGTG
  CGGACCCTGTCGGGCATGTGCAGCGGCCACCAAGCCAGAGCCACAGTGATTCTGCATGCA
  GTGCGGATAGACCGAATCTGTAGCCTCATGGCCGTGGAGAATGAGGAGATGTCTCTGGCT
  GTCTGCAACCTGCTCCAAGCCATCATTGACTCCTTGTCTGGGGAGGACAAGCGGGAGCAT
  CGAGGGAAGGAGGAGGCCCTGGTTCTAGACACCAAGAAGGACCTGAAGCAGATCACCAGC
  CACCTGCTGGACATGCTAGTCAGCAAGAAGGTGTCTGGCCAGGGCAGGGATCAGGCGCTG
  AACCTGCTCAATAAGAATGTTCCCAGGAAGGACCTTGCCATTCATGACAACTCACGTACC
  ATCTATGTGGTGGATAATGGTCTGAGGAAGATCCTGAAGGTTGTGGGGCAGGTTCCAGAT
  CTGCCATCCTGCCTGCCCCTGACTGACAACACCCGCATGCTGGCCTCTATCCTCATCAAC
  AAGCTCTATGATGACCTGCGCTGTGACCCGGAGCGCGATCACTTCCGCAAGATCTGTGAG
  GAATATATCACGGGCAAGTTTGACCCCCAGGACATGGACAAGAACTTGAATGCCATCCAG
  ACAGTGTCAGGGATCCTGCAGGGCCCCTTTGACCTGGGCAACCAGCTGCTGGGACTGAAA
  GGTGTGATGGAGATGATGGTGGCACTATGTGGCTCAGAGCGCGAGACGGACCAGCTGGTG
  GCCGTGGAGGCCCTCATCCATGCCTCCACGAAGCTCAGCCGCGCCACCTTCATCATCACC
  AATGGAGTGTCACTGCTCAAACAGATCTACAAGACCACCAAAAATGAGAAGATCAAGATC
  CGCACACTGGTGGGACTCTGTAAGCTCGGCTCTGCAGGTGGCACAGACTACGGTCTCAGG
  CAGTTTGCGGAAGGGTCGACAGAAAAACTGGCCAAACAGTGTCGCAAGTGGCTGTGCAAT
  ATGTCCATAGACACTCGGACCCGACGCTGGGCAGTGGAGGGCCTGGCCTACCTCACGCTG
  GACGCTGATGTGAAGGACGACTTTGTCCAGGACGTCCCTGCCCTGCAGGCCATGTTTGAG
  CTGGCCAAGACCAGTGACAAGACCATCCTGTACTCGGTGGCCACCACCCTGGTGAACTGC
  ACCAACAGCTACGATGTCAAGGAGGTCATCCCAGAGCTTGTCCAGCTCGCCAAGTTCTCC
  AAGCAGCATGTGCCCGAGGAACACCCCAAGGACAAGAAGGACTTTATAGACATGCGGGTG
  AAGCGGCTTCTGAAGGCGGGTGTCATCTCTGCCCTGGCTTGCATGGTGAAAGCAGATAGT
  GCCATCCTCACTGACCAGACCAAGGAGCTGCTGGCCAGGGTATTCCTGGCACTGTGTGAC
  AACCCAAAGGACCGAGGCACCATTGTGGCTCAAGGTGGTGGCAAGGCCCTGATTCCCCTG
  GCTTTGGAGGGCACAGATGTGGGCAAGGTGAAGGCAGCCCACGCTCTAGCAAAGATCGCT
  GCTGTCTCCAATCCGGACATTGCTTTTCCTGGGGAGCGGGTGTATGAGGTGGTGCGGCCC
  CTTGTAAGACTCTTGGACACACAGAGGGATGGGCTTCAGAACTATGAGGCTCTCCTAGGC
  CTCACCAACCTGTCTGGGCGGAGTGACAAACTCCGGCAGAAGATCTTTAAGGAGAGGGCC
  TTGCCAGACATCGAGAACTACATGTTTGAGAATCATGATCAGCTGCGGCAGGCGGCCACC
  GAGTGCATGTGCAACATGGTGCTCCACAAGGAGGTACAGGAAAGGTTCTTGGCTGACGGG
  AATGACCGGCTGAAGCTGGTGGTGCTGCTCTGCGGGGAGGATGATGATAAGGTGCAGAAT
  GCGGCTGCAGGGGCTCTGGCCATGCTGACAGCAGCACACAAGAAACTGTGCCTCAAGATG
  ACTCAAGTGACAACCCAGTGGTTGGAGATCCTCCAGCGGCTTTGCCTGCACGACCAGCTG
  TCTGTCCAACACCGGGGCCTGGTCATTGCCTACAACCTACTGGCAGCCGATGCTGAGCTG
  GCCAAGAAGCTGGTGGAGAGTGAGCTGCTGGAGATCCTGACTGTGGTGGGCAAACAGGAG
  CCAGATGAGAAGAAGGCAGAAGTGGTTCAGACAGCCCGAGAATGTCTCATCAAGTGCATG
  GATTATGGTTTCATTAAACCAGTGTCTTAG
  
• Restriction Sites: Please inquire
• ACCN: NM_001033576
• ORF Size: 2790 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001033576.1, NP_001028748.1
• RefSeq Size: 5688
• RefSeq ORF: 2790
• Locus ID: 146862
• Gene Summary: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
  Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).