PTPRN (NM_002846) Human Untagged Clone

CAT#: SC303245

PTPRN (untagged)-Human protein tyrosine phosphatase, receptor type, N (PTPRN), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PTPRN
• Synonyms: IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
• Vector: PCMV6-Neo
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002846 edited
  ATGCGGCGCCCGCGGCGGCCTGGGGGTCTCGGGGGATCCGGGGGTCTCCGGCTGCTCCTC
  TGCCTCCTGCTGCTGAGCAGCCGCCCGGGGGGCTGCAGCGCCGTTAGTGCCCACGGCTGT
  CTATTTGACCGCAGGCTCTGCTCTCACCTGGAAGTCTGTATTCAGGATGGCTTGTTTGGG
  CAGTGCCAGGTGGGAGTGGGGCAGGCCCGGCCCCTTTTGCAAGTCACCTCCCCAGTTCTC
  CAACGCTTACAAGGTGTGCTCCGACAACTCATGTCCCAAGGATTGTCCTGGCACGATGAC
  CTCACCCAGTATGTGATCTCTCAGGAGATGGAGCGCATCCCCAGGCTTCGCCCCCCAGAG
  CCCCGTCCAAGGGACAGGTCTGGCTTGGCACCCAAGAGACCTGGTCCTGCTGGAGAGCTG
  CTTTTACAGGACATCCCCACTGGCTCCGCCCCTGCTGCCCAGCATCGGCTTCCACAACCA
  CCAGTGGGCAAAGGTGGAGCTGGGGCCAGCTCCTCTCTGTCCCCTCTGCAGGCTGAGCTG
  CTCCCGCCTCTCTTGGAGCACCTGCTGCTGCCCCCACAGCCTCCCCACCCTTCACTGAGT
  TACGAACCTGCCTTGCTGCAGCCCTACCTGTTCCACCAGTTTGGCTCCCGTGATGGCTCC
  AGGGTCTCAGAGGGCTCCCCAGGGATGGTCAGTGTCGGCCCCCTGCCCAAGGCTGAAGCC
  CCTGCCCTCTTCAGCAGAACTGCCTCCAAGGGCATATTTGGGGACCACCCTGGCCACTCC
  TACGGGGACCTTCCAGGGCCTTCACCTGCCCAGCTTTTTCAAGACTCTGGGCTGCTCTAT
  CTGGCCCAGGAGTTGCCAGCACCCAGCAGGGCCAGGGTGCCAAGGCTGCCAGAGCAAGGG
  AGCAGCAGCCGGGCAGAGGACTCCCCAGAGGGCTATGAGAAGGAAGGACTAGGGGATCGT
  GGAGAGAAGCCTGCTTCCCCAGCTGTGCAGCCAGATGCGGCTCTGCAGAGGCTGGCCGCT
  GTGCTGGCGGGCTATGGGGTAGAGCTGCGTCAGCTGACCCCTGAGCAGCTCTCCACACTC
  CTGACCCTGCTGCAGCTACTGCCCAAGGGTGCAGGAAGAAATCCGGGAGGGGTTGTAAAT
  GTTGGAGCTGATATCAAGAAAACAATGGAGGGGCCGGTGGAGGGCAGAGACACAGCAGAG
  CTTCCAGCCCGCACATCCCCCATGCCTGGACACCCCACTGCCAGCCCTACCTCCAGTGAA
  GTCCAGCAGGTGCCAAGCCCTGTCTCCTCTGAGCCTCCCAAAGCTGCCAGACCCCCTGTG
  ACACCTGTCCTGCTAGAGAAGAAAAGCCCACTGGGCCAGAGCCAGCCCACGGTGGCAGGA
  CAGCCCTCAGCCCGCCCAGCAGCAGAGGAATATGGCTACATCGTCACTGATCAGAAGCCC
  CTGAGCCTGGCTGCAGGAGTGAAGCTGCTGGAGATCCTGGCTGAGCATGTGCACATGTCC
  TCAGGCAGCTTCATCAACATCAGTGTGGTGGGACCAGCCCTCACCTTCCGCATCCGGCAC
  AATGAGCAGAACCTGTCTTTGGCTGATGTGACCCAACAAGCAGGGCTGGTGAAGTCTGAA
  CTGGAAGCACAGACAGGGCTCCAAATCTTGCAGACAGGAGTGGGACAGAGGGAGGAGGCA
  GCTGCAGTCCTTCCCCAAACTGCGCACAGCACCTCACCCATGCGCTCAGTGCTGCTCACT
  CTGGTGGCCCTGGCAGGTGTGGCTGGGCTGCTGGTGGCTCTGGCTGTGGCTCTGTGTGTG
  CGGCAGCATGCGCGGCAGCAAGACAAGGAGCGCCTGGCAGCCCTGGGGCCTGAGGGGGCC
  CATGGTGACACTACCTTTGAGTACCAGGACCTGTGCCGCCAGCACATGGCCACGAAGTCC
  TTGTTCAACCGGGCAGAGGGTCCACCGGAGCCTTCACGGGTGAGCAGTGTGTCCTCCCAG
  TTCAGCGACGCAGCCCAGGCCAGCCCCAGCTCCCACAGCAGCACCCCGTCCTGGTGCGAG
  GAGCCGGCCCAAGCCAACATGGACATCTCCACGGGACACATGATTCTGGCATACATGGAG
  GATCACCTGCGGAACCGGGACCGCCTTGCCAAGGAGTGGCAGGCCCTCTGTGCCTACCAA
  GCAGAGCCAAACACCTGTGCCACCGCGCAGGGGGAGGGCAACATCAAAAAGAACCGGCAT
  CCTGACTTCCTGCCCTATGACCATGCCCGCATAAAACTGAAGGTGGAGAGCAGCCCTTCT
  CGGAGCGATTACATCAACGCCAGCCCCATTATTGAGCATGACCCTCGGATGCCAGCCTAC
  ATAGCCACGCAGGGCCCGCTGTCCCATACCATCGCAGACTTCTGGCAGATGGTGTGGGAG
  AGCGGCTGCACCGTCATCGTCATGCTGACCCCGCTGGTGGAGGATGGTGTCAAGCAGTGT
  GACCGCTACTGGCCAGATGAGGGTGCCTCCCTCTACCACGTATATGAGGTGAACCTGGTG
  TCGGAGCACATCTGGTGCGAGGACTTTCTGGTGCGGAGCTTCTACCTGAAGAACGTGCAG
  ACCCAGGAGACGCGCACGCTCACGCAGTTCCACTTCCTCAGCTGGCCGGCAGAGGGCACA
  CCGGCCTCCACGCGGCCCCTGCTGGACTTCCGCAGGAAGGTGAACAAGTGCTACCGGGGC
  CGCTCCTGCCCCATCATCGTGCACTGCAGTGATGGTGCGGGGAGGACCGGCACCTACATC
  CTCATCGACATGGTCCTGAACCGCATGGCAAAAGGAGTGAAGGAGATTGACATCGCTGCC
  ACCCTGGAGCATGTCCGTGACCAGCGGCCTGGCCTTGTCCGCTCTAAGGACCAGTTTGAA
  TTTGCCCTGACAGCCGTGGCGGAGGAAGTGAATGCCATCCTCAAGGCCCTGCCCCAGTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_002846
• Insert Size: 2900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002846.2, NP_002837.1
• RefSeq Size: 3649 bp
• RefSeq ORF: 2940 bp
• Locus ID: 5798
• Cytogenetics: 2q35
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Type I diabetes mellitus
• Gene Summary: 'The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]'
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).