DVL1 (NM_004421) Human Untagged Clone

CAT#: SC303481

DVL1 (untagged)-Human dishevelled, dsh homolog 1 (Drosophila) (DVL1)


  "NM_004421" in other vectors (6)

Reconstitution Protocol

USD 1,370.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol DVL1
Synonyms DRS2; DVL; DVL1L1; DVL1P1
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_004421 edited
ATGGCGGAGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAG
CTGCCCGTGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGG
CCCGTGCACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGGGGTGGTGAAG
GAGGAGATCTTTGATGACAATGCCAAGCTTCCCTGCTTCAACGGCCGCGTGGTCTCCTGG
CTGGTCCTGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCACGGACAGCCACACA
GACCTGCCCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTCCTTC
CACCCGAATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATG
GTCAGTCACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGCCGCCCGGACCAAT
GGGCACCCAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACC
GCCCTCAGCAGCGAGCTTGAGTCCAGCAGCTTTGTGGACTCGGACGAGGATGGCAGCACG
AGCAGGCTCAGCAGCTCCACGGAGCAGAGCACCTCATCCAGACTCATCCGGAAGCACAAA
CGCCGGCGGAGGAAGCAGCGCCTTCGGCAGGCGGACCGGGCCTCCTCCTTCAGCAGCATA
ACCGACTCCACCATGTCCCTCAACATCGTCACTGTCACGCTCAACATGGAAAGACATCAC
TTTCTGGGCATCAGCATCGTGGGGCAGAGCAACGACCGTGGAGACGGCGGCATCTACATT
GGCTCCATCATGAAGGGCGGGGCTGTGGCCGCTGACGGCCGCATCGAGCCCGGCGACATG
TTGCTGCAGGTGAATGACGTGAACTTTGAGAACATGAGCAATGACGATGCCGTGCGGGTG
CTGCGGGAGATCGTTTCCCAGACGGGGCCCATCAGCCTCACTGTGGCCAAGTGCTGGGAC
CCAACGCCCCGAAGCTACTTCACCGTCCCACGGGCTGACCCGGTGCGGCCCATCGACCCC
GCCGCCTGGCTGTCCCACACGGCGGCACTGACAGGAGCCCTGCCCCGCTACGAGCTGGAA
GAGGCGCCGCTGACGGTGAAGAGTGACATGAGCGCCGTCGTCCGGGTCATGCAGCTGCCA
GACTCGGGACTGGAGATCCGCGACCGCATGTGGCTCAAGATCACCATCGCCAATGCCGTC
ATCGGGGCGGACGTGGTGGACTGGCTGTACACACACGTGGAGGGCTTCAAGGAGCGGCGG
GAGGCCCGGAAGTACGCCAGCAGCTTGCTGAAGCACGGCTTCCTGCGGCACACGGTCAAC
AAGATCACCTTCTCCGAGCAGTGCTACTACGTCTTCGGGGATCTCTGCAGCAATCTCGCC
ACCCTGAACCTCAACAGTGGCTCCAGTGGGACTTCGGATCAGGACACGCTGGCCCCGCTG
CCCCACCCGGCTGCCCCCTGGCCTCTGGGTCAGGGCTACCCCTACCAGTACCCGGGACCC
CCACCCTGCTTCCCGCCTGCCTACCAGGACCCGGGCTTTAGCTATGGCAGCGGCAGCACC
GGGAGTCAGCAGAGTGAAGGGAGCAAAAGCAGTGGGTCCACCCGGAGCAGCCGCCGGGCC
CCGGGCCGTGAGAAGGAGCGTCGGGCGGCGGGAGCTGGGGGCAGTGGCAGTGAATCGGAT
CACACGGCACCGAGTGGGGTGGGGAGCAGCTGGCGAGAGCGTCCGGCCGGCCAGCTCAGC
CGTGGCAGCAGCCCACGCAGTCAGGCCTCGGCTACCGCCCCGGGGCTCCCCCCGCCCCAC
CCCACGACCAAGGCCTATACAGTGGTGGGGGGGCCACCCGGGGGACCCCCTGTCCGGGAG
CTGGCTGCCGTCCCCCCGGAATTGACAGGCAGCCGCCAGTCCTTCCAGAAGGCTATGGGG
AACCCCTGCGAGTTCTTCGTGGACATCATGTGA
>OriGene 5' read for NM_004421 unedited
CGTCTGAATTTGTATACGACTCATATAGGGCGGCCGCGAATTCGCACGAGGCGCCCCGCG
TCCGAGCCTCGGGCCGGGCCCTGAGCGCGCGGGCTCCGCGCCGCCGCCGCGCCATGGCGG
AGACCAAGATTATCTACCACATGGACGAGGAGGAGACGCCGTACCTGGTCAAGCTGCCCG
TGGCCCCCGAGCGCGTCACGCTGGCCGACTTCAAGAACGTGCTCAGCAACCGGCCCGTGC
ACGCCTACAAATTCTTCTTTAAGTCCATGGACCAGGACTTCGGGGTGGTGAAGGAGGAGA
TCTTTGATGACAATGCCAAGCTTCCCTGCTTCAACGGCCGCGTGGTCTCCTGGCTGGTCC
TGGCTGAGGGTGCTCACTCGGATGCGGGGTCCCAGGGCACGGACAGCCACACAGACCTGC
CCCCGCCTCTTGAGCGGACAGGCGGCATCGGGGACTCCCGGCCCCCCTCCTTCCACCCGA
ATGTGGCCAGCAGCCGTGACGGGATGGACAACGAGACAGGCACGGAGTCCATGGTCAGTC
ACCGGCGGGAGCGTGCCCGACGCCGGAACCGCGAGGAGGCCGCCCGGACCAATGGGCACC
CAAGGGGAGACCGACGGCGGGATGTGGGGCTGCCCCCAGACAGCGCGTCCACCGCCCTCA
GCAGCGAGCTTGAGTCCAGCAGCTTTGTGGNACTCGACGAGGATGGCAGCACGAGCAGGC
TCAGCAGCNTCACGGAGCAGAGCACCTCATCCAGACTCATCCGGAAGCACAAACGCCCGG
CGGNAGAAGCAGCGCCTTTTCGCAGGCGACCGGGCCTCCTNCTTCAGCAGCATAACCGAC
TTCACCATGT
>OriGene 3' read for NM_004421 unedited
NCGCCGCCAGTGGAGGCAATTCGAGCCAGGAAGCATGGGGAGGGTCAAGGGTGCCCCCGG
GCTCGTTCAGAAAAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTT
TTTAAAATTAAACGCTTTTTAGTGTTTAAAATAAGCAGCATTTTACACAGAAGCAGCTTC
TTTGTTTAACCATCTAAACGCTGGGACTTTGATACAGTATCTACAGCACAGACACGTTGG
GGGCCAGAGAAGCCAGGAAGGCCGCGATGTGTGCGCGCAGTGTGTGCACTCACCAAGGAC
GGGCCACCTGACTGCCCATCTCCCCAAGACCTCCCTCCCTGTGGCAGCTGTGCACATCGG
GGCCCCTTGACCCTGCGGGCCATGGTCCCTCCCTGCCCTGGCTGGGACACGGTGGGCAGG
ATGTCCAGCCCTCTCTCGTCTTCCGGTCCCGTCCTCCACGTACTTTCAGACTGTTGCCGG
ATGGGAGGAGAGAAGGTGCAGGCTGCTCCAAGGGGCAGCAGCAGGTGGGACAGATGACAG
GGTCGCCTCCTCCCCCGAGTCACCGGCCAGGCAATAAATAAATAAATTAGATCCCTACTC
CAGACAGGGGGCCTGTGCACCGCAGGGGGTTGCCCCGCGTGGACCACCCTGGGGGCCTGG
GCACAGCTGTGCAGGAGGTGGGGGTCAGCCGAGAGCCCGAGGGGGTCTTCCTCATCCCAG
GAGGGATCCCCACCAGACACAAGGGGTTTTGGGAGGTCCGAGGCTTCTCGCTGAGGGGCA
GAGAGGGAGCGCCCCCAACACGGCTGCTCAGACACAGGTGCTGTCAGGAGCTGGAGCAGC
CAGGCTGCCAGGGCAGATGGTGGTT
Restriction Sites NotI-NotI     
ACCN NM_004421
Insert Size 3000 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_004421.2, NP_004412.2
RefSeq Size 2941 bp
RefSeq ORF 2013 bp
Locus ID 1855
Cytogenetics 1p36.33
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Basal cell carcinoma, Colorectal cancer, Melanogenesis, Notch signaling pathway, Pathways in cancer, Wnt signaling pathway
Gene Summary 'DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]'
Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

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