GAB2 (NM_012296) Human Untagged Clone

CAT#: SC303953

GAB2 (untagged)-Human GRB2-associated binding protein 2 (GAB2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GAB2
• Synonyms: KIAA0571
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_012296, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAGCGGTGACCCAGATGTTCTGGAATACTACAAGAACGATCACTCCAAGAAGCCTCTGCGGATCATCA
  ACCTGAACTTCTGTGAGCAGGTAGATGCAGGCCTGACCTTTAACAAGAAGGAGCTGCAGGATAGTTTTGT
  GTTTGACATCAAGACCAGTGAACGCACCTTTTACCTGGTGGCTGAGACAGAAGAGGACATGAATAAGTGG
  GTCCAGAGCATCTGCCAGATCTGTGGCTTCAATCAGGCTGAGGAGAGCACAGACTCCCTGAGAAATGTTT
  CCTCAGCCGGTCATGGCCCCCGCTCTTCTCCAGCTGAGCTCAGCAGCTCTAGCCAGCACCTTCTCCGAGA
  GCGCAAGTCCTCAGCCCCATCACACTCCAGCCAGCCAACTCTGTTCACGTTTGAACCCCCTGTGTCAAAC
  CACATGCAGCCCACCTTGTCCACCAGCGCACCTCAGGAGTATCTCTACTTGCACCAGTGCATAAGCCGAA
  GAGCAGAAAATGCAAGGAGTGCCAGCTTCTCTCAGGGCACCAGAGCCTCTTTTCTCATGAGGAGTGACAC
  AGCTGTACAAAAACTTGCCCAGGGCAATGGACACTGTGTCAACGGGATCAGTGGTCAAGTCCATGGCTTC
  TATAGCCTTCCCAAGCCGAGCCGGCACAATACAGAATTCAGAGACAGTACCTACGACCTCCCCCGCAGCC
  TGGCCTCCCATGGCCACACCAAGGGCAGCCTCACAGGCTCCGAGACAGATAATGAGGATGTGTACACCTT
  CAAGACGCCCAGCAACACCCTGTGCAGGGAGTTCGGGGACCTCCTGGTAGACAATATGGATGTTCCGGCC
  ACCCCACTCTCAGCCTACCAGATCCCTAGGACATTCACTCTGGACAAAAACCACAATGCCATGACAGTGG
  CCACTCCTGGGGACTCAGCCATAGCTCCCCCACCCCGCCCCCCCAAGCCAAGTCAGGCAGAAACACCTCG
  ATGGGGCAGTCCTCAGCAGAGACCGCCAATCAGTGAAAATAGCAGATCTGTCGCTGCCACCATCCCCAGA
  CGCAACACCCTCCCTGCAATGGACAACAGCCGACTTCACCGAGCTTCTTCCTGTGAGACCTACGAGTACC
  CACAGCGTGGTGGAGAGAGTGCAGGCCGGTCTGCTGAATCCATGAGTGATGGAGTTGGCTCTTTCCTGCC
  AGGGAAAATGATTGTGGGCCGATCGGACAGCACCAATTCTGAAGACAACTATGTGCCCATGAATCCAGGT
  TCTTCCACCCTGTTGGCCATGGAACGAGCAGGTGATAATTCCCAGAGCGTCTACATCCCAATGAGCCCAG
  GGGCCCATCACTTTGACTCACTTGGCTACCCATCAACAACCCTTCCTGTGCACCGAGGCCCCAGCAGAGG
  AAGTGAGATTCAGCCACCCCCTGTCAACCGCAACCTCAAACCTGATCGGAAAGCAAAGCCAACACCACTT
  GACCTGAGGAACAACACCGTCATCGATGAACTCCCCTTCAAGTCACCTATCACCAAGTCTTGGTCTAGGG
  CCAACCACACCTTCAACTCCAGCTCCTCCCAGTACTGCCGCCCCATCTCCACCCAGAGCATCACCAGCAC
  AGACTCAGGAGACAGCGAAGAGAACTATGTCCCTATGCAAAACCCAGTGTCTGCATCTCCCGTTCCCAGT
  GGCACGAACAGTCCTGCCCCTAAGAAGAGCACCGGCAGCGTTGATTATCTGGCCCTGGACTTCCAGCCGA
  GCTCCCCAAGCCCCCACCGCAAGCCATCTACTTCATCCGTCACCTCTGATGAGAAGGTGGACTACGTTCA
  GGTGGACAAGGAGAAGACCCAGGCCCTGCAGAACACCATGCAGGAGTGGACAGACGTGCGGCAGTCCTCA
  GAGCCTTCCAAGGGTGCCAAGCTGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_012296
• ORF Size: 1917 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_012296.3, NP_036428.1
• RefSeq Size: 6062
• RefSeq ORF: 1917
• Locus ID: 9846
• Protein Families: Druggable Genome
• Protein Pathways: Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis
• Gene Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
  Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.