LPHN1 (ADGRL1) (NM_014921) Human Untagged Clone

CAT#: SC304185

LPHN1 (untagged)-Human latrophilin 1 (LPHN1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADGRL1
• Synonyms: CIRL1; CL1; LEC2; LPHN1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_014921 edited
  ATGGCCCGCCTAGCCGCAGTGCTCTGGAATCTGTGTGTCACCGCCGTCCTGGTCACCTCG
  GCCACCCAAGGCCTGAGCCGGGCCGGGCTCCCGTTCGGGCTGATGCGCCGGGAGCTGGCG
  TGTGAAGGCTACCCCATCGAGCTGCGGTGCCCCGGCAGCGACGTCATCATGGTGGAGAAT
  GCCAACTACGGGCGCACGGACGACAAGATTTGCGATGCTGACCCTTTCCAGATGGAGAAT
  GTGCAGTGCTACCTGCCGGACGCCTTCAAGATCATGTCACAGAGGTGTAACAACCGCACC
  CAGTGCGTGGTGGTCGCCGGCTCGGATGCCTTTCCTGACCCCTGTCCTGGGACCTACAAG
  CACCTGGAGGTGCAGTACGACTGTGTCCCCTACATCTTCGTGTGCCCAGGGACCCTGCAG
  AAGGTGCTGGAGCCCACCTCGACACACGAGTCAGAGCACCAGTCTGGCGCATGGTGCAAG
  GACCCGCTGCAGGCGGGTGACCGCATCTACGTGATGCCCTGGATCCCCTACCGCACGGAC
  ACACTGACTGAGTATGCCTCGTGGGAGGACTACGTGGCCGCCCGCCACACCACCACCTAC
  CGCCTGCCCAACCGCGTGGATGGCACAGGCTTTGTGGTCTACGATGGTGCCGTCTTCTAC
  AACAAGGAGCGCACGCGCAACATCGTCAAGTATGACCTACGGACGCGCATCAAGAGCGGG
  GAGACGGTCATCAATACCGCCAACTACCATGACACCTCGCCCTACCGCTGGGGCGGAAAG
  ACCGACATTGACCTGGCGGTGGACGAGAACGGGCTGTGGGTCATCTACGCCACTGAGGGC
  AACAACGGGCGGCTGGTGGTGAGCCAGCTGAACCCCTACACACTGCGCTTTGAGGGCACG
  TGGGAGACGGGTTACGACAAGCGCTCGGCATCCAACGCCTTCATGGTGTGTGGGGTCCTG
  TACGTCCTGCGTTCCGTGTACGTGGATGATGACAGCGAGGCGGCTGGCAACCGCGTGGAC
  TATGCCTTCAACACCAATGCCAACCGCGAGGAGCCTGTCAGCCTCACCTTCCCCAACCCC
  TACCAGTTCATCTCCTCCGTTGACTACAACCCTCGCGACAACCAGCTGTACGTCTGGAAC
  AACTATTTCGTGGTGCGCTACAGCCTGGAGTTCGGGCCGCCCGACCCCAGTGCTGGCCCA
  GCCACTTCCCCACCCCTCAGCACGACCACCACAGCCAGGCCCACGCCCCTCACCAGCACA
  GCCTCGCCCGCAGCCACCACCCCGCTCCGCCGGGCACCCCTCACCACGCACCCAGTGGGT
  GCCATCAACCAGCTGGGACCTGATCTGCCTCCAGCCACAGCCCCAGTCCCCAGCACCCGG
  CGGCCCCCAGCCCCGAATCTACACGTGTCCCCTGAGCTCTTCTGCGAGCCCCGAGAGGTA
  CGGCGGGTCCAGTGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAG
  GGGACTCGAGGAATTGCCTCCTTCCAGTGTCTACCAGCCTTGGGGCTCTGGAACCCCCGG
  GGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGCCCAGAAGATCAAG
  AGTGGGGAGAACGCGGCCAACATCGCCAGCGAGCTGGCCCGACACACCCGGGGCTCCATC
  TACGCGGGGGACGTCTCCTCCTCTGTGAAGCTGATGGAGCAGCTGCTGGACATCCTGGAT
  GCCCAGCTGCAGGCCCTGCGGCCCATCGAGCGCGAGTCAGCCGGCAAGAACTACAACAAG
  ATGCACAAGCGAGAGAGAACTTGTAAGGATTATATCAAGGCCGTGGTGGAGACAGTGGAC
  AATCTGCTCCGGCCAGAAGCTCTGGAGTCCTGGAAGGACATGAATGCCACGGAGCAGGTG
  CACACGGCCACCATGCTCCTCGACGTCCTGGAGGAGGGCGCCTTCCTGCTGGCCGACAAT
  GTCAGGGAGCCTGCCCGCTTCCTGGCTGCCAAGGAGAACGTGGTCCTGGAGGTCACAGTC
  CTGAACACAGAGGGCCAGGTGCAGGAGCTGGTGTTCCCCCACGAGGAGTACCCGAGAAAG
  AACTCCATCCAGCTGTCTGCCAAAACCATCAAGCAGAACAGCCGCAATGGGGTGGTCAAA
  GTTGTCTTCATCCTCTACAACAACCTGGGCCTCTTCCTGTCCACGGAGAATGCCACAGTG
  AAGCTGGCCGGCGAAGCAGGCCCGGGTGGCCCTGGGGGCGCCTCTCTAGTGGTGAACTCA
  CAGGTCATCGCAGCATCCATCAACAAGGAGTCCAGCCGCGTCTTCCTCATGGACCCTGTC
  ATCTTCACCGTGGCCCACCTGGAGGACAAGAACCACTTCAATGCTAACTGCTCCTTCTGG
  AACTACTCGGAGCGTTCCATGCTGGGCTACTGGTCGACCCAAGGCTGCCGCCTGGTGGAG
  TCCAACAAGACCCATACCACGTGTGCCTGCAGCCACCTCACCAACTTCGCTGTGCTCATG
  GCTCACCGTGAGATCTACCAGGGCCGCATCAACGAGCTGCTGCTGTCGGTCATCACCTGG
  GTGGGCATTGTGATCTCCCTGGTCTGCTTGGCCATCTGCATCTCCACCTTCTGCTTCCTG
  CGGGGGCTGCAGACCGACCGCAACACCATCCACAAGAACCTGTGCATCAACCTCTTCCTG
  GCTGAGCTGCTCTTCCTGGTCGGGATCGACAAGACTCAGTATGAGATTGCCTGCCCCATC
  TTCGCCGGCCTGCTGCACTATTTCTTCCTGGCTGCCTTCTCCTGGCTGTGCCTGGAGGGC
  GTGCACCTCTACCTGCTACTAGTGGAGGTGTTTGAGAGCGAGTATTCCCGCACCAAGTAC
  TACTACCTGGGTGGCTACTGCTTCCCGGCCCTGGTGGTGGGCATCGCGGCTGCCATTGAC
  TACCGCAGCTACGGCACCGAGAAGGCCTGCTGGCTCCGAGTGGACAATTACTTCATCTGG
  AGTTTCATCGGGCCAGTCTCCTTCGTTATCGTGGTCAACCTGGTGTTCCTCATGGTGACC
  CTGCACAAGATGATCCGAAGCTCATCTGTGCTCAAGCCCGACTCCAGCCGCCTGGACAAC
  ATTAAATCCTGGGCGCTGGGGGCCATCGCGCTGCTGTTCCTGCTGGGCCTCACCTGGGCT
  TTCGGCCTCCTCTTCATCAACAAGGAGTCGGTGGTCATGGCCTATCTCTTCACCACCTTC
  AACGCCTTCCAGGGGGTCTTCATCTTCGTCTTTCACTGCGCCTTACAGAAGAAGGTGCAC
  AAGGAGTACAGCAAGTGCCTGCGTCACTCCTACTGCTGCATCCGCTCCCCACCCGGGGGC
  ACTCACGGATCCCTCAAGACCTCAGCCATGCGAAGCAACACCCGCTACTACACAGGGACC
  CAGAGCCGAATTCGGAGGATGTGGAATGACACTGTGAGGAAACAGACGGAGTCCTCCTTC
  ATGGCGGGTGACATCAACAGCACCCCCACCCTGAACCGAGGTACCATGGGGAACCACCTG
  CTGACCAACCCCGTGCTGCAGCCCCGTGGGGGCACCAGTCCCTACAACACCCTCATCGCC
  GAGTCAGTGGGCTTCAATCCCTCCTCGCCCCCTGTCTTCAACTCCCCAGGGAGCTACCGG
  GAACCCAAGCACCCCTTGGGAGGCCGGGAAGCCTGTGGCATGGACACCCTGCCCCTGAAC
  GGCAACTTCAATAACAGTTACTCCTTGCGAAGTGGGGATTTCCCTCCCGGGGATGGGGGC
  CCTGAGCCGCCCCGAGGCCGGAACCTAGCCGATGCGGCGGCCTTTGAGAAGATGATCATC
  TCAGAGCTGGTGCACAACAACCTGCGGGGGAGCAGCAGCGCGGCCAAGGGCCCTCCACCG
  CCTGAGCCCCCTGTGCCACCTGTGCCAGGGGGCGGGGGCGAGGAAGAGGCGGGCGGGCCC
  GGGGGTGCTGACCGGGCCGAGATTGAACTTCTCTATAAGGCCCTGGAGGAGCCTCTGCTG
  CTGCCCCGGGCCCAGTCGGTGCTGTACCAGAGCGATCTGGACGAGTCGGAGAGCTGCACG
  GCCGAGGACGGCGCCACCAGCCGGCCCCTCTCCTCCCCTCCTGGCCGGGACTCCCTCTAT
  GCCAGCGGGGCCAACCTGCGGGACTCACCCTCCTACCCGGACAGCAGCCCTGAGGGGCCC
  AGTGAGGCCCTGCCCCCACCCCCTCCCGCACCCCCCGGCCCCCCCGAAATCTACTACACC
  TCGCGCCCGCCAGCCCTGGTGGCCCGGAATCCCCTGCAGGGCTACTACCAGGTGCGGCGT
  CCTAGCCACGAGGGCTACCTGGCAGCCCCAGGCCTTGAGGGGCCAGGGCCCGATGGGGAC
  GGGCAGATGCAGCTGGTCACCAGTCTCTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_014921
• ORF Size: 4410 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014921.3, NP_055736.2
• RefSeq Size: 7871
• RefSeq ORF: 4410
• Locus ID: 22859
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
  Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.