SLC22A17 (NM_016609) Human Untagged Clone

CAT#: SC304438

SLC22A17 (untagged)-Human solute carrier family 22, member 17 (SLC22A17), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SLC22A17
• Synonyms: 24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2; NGALR3
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_016609, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCTCGGACCCCATCTTCACGCTGGCGCCCCCGCTGCATTGCCACTACGGGGCCTTCCCCCCTAATG
  CCTCTGGCTGGGAGCAGCCTCCCAATGCCAGCGGCGTCAGCGTCGCCAGCGCTGCCCTAGCAGCCAGCGC
  CGCCAGCCGTGTCGCCACCAGTACCGACCCCTCGTGCAGCGGCTTCGCCCCGCCGGACTTCAACCATTGC
  CTCAAGGATTGGGACTATAATGGCCTTCCTGTGCTCACCACCAACGCCATCGGCCAGTGGGATCTGGTGT
  GTGACCTGGGCTGGCAGGTGATCCTGGAGCAGATCCTCTTCATCTTGGGCTTTGCCTCCGGCTACCTGTT
  CCTGGGTTACCCCGCAGACAGATTTGGCCGTCGCGGGATTGTGCTGCTGACCTTGGGGCTGGTGGGCCCC
  TGTGGAGTAGGAGGGGCTGCTGCAGGCTCCTCCACAGGCGTCATGGCCCTCCGATTCCTCTTGGGCTTTC
  TGCTTGCCGGTGTTGACCTGGGTGTCTACCTGATGCGCCTGGAGCTGTGCGACCCAACCCAGAGGCTTCG
  GGTGGCCCTGGCAGGGGAGTTGGTGGGGGTGGGAGGGCACTTCCTGTTCCTGGGCCTGGCCCTTGTCTCT
  AAGGATTGGCGATTCCTACAGCGAATGATCACCGCTCCCTGCATCCTCTTCCTGTTTTATGGCTGGCCTG
  GTTTGTTCCTGGAGTCCGCACGGTGGCTGATAGTGAAGCGGCAGATTGAGGAGGCTCAGTCTGTGCTGAG
  GATCCTGGCTGAGCGAAACCGGCCCCATGGGCAGATGCTGGGGGAGGAGGCCCAGGAGGCCCTGCAGGAC
  CTGGAGAATACCTGCCCTCTCCCTGCAACATCCTCCTTTTCCTTTGCTTCCCTCCTCAACTACCGCAACA
  TCTGGAAAAATCTGCTTATCCTGGGCTTCACCAACTTCATTGCCCATGCCATTCGCCACTGCTACCAGCC
  TGTGGGAGGAGGAGGGAGCCCATCGGACTTCTACCTGTGCTCTCTGCTGGCCAGCGGCACCGCAGCCCTG
  GCCTGTGTCTTCCTGGGGGTCACCGTGGACCGATTTGGCCGCCGGGGCATCCTTCTTCTCTCCATGACCC
  TTACCGGCATTGCTTCCCTGGTCCTGCTGGGCCTGTGGGATTATCTGAACGAGGCTGCCATCACCACTTT
  CTCTGTCCTTGGGCTCTTCTCCTCCCAAGCTGCCGCCATCCTCAGCACCCTCCTTGCTGCTGAGGTCATC
  CCCACCACTGTCCGGGGCCGTGGCCTGGGCCTGATCATGGCTCTAGGGGCGCTTGGAGGACTGAGCGGCC
  CGGCCCAGCGCCTCCACATGGGCCATGGAGCCTTCCTGCAGCACGTGGTGCTGGCGGCCTGCGCCCTCCT
  CTGCATTCTCAGCATTATGCTGCTGCCGGAGACCAAGCGCAAGCTCCTGCCCGAGGTGCTCCGGGACGGG
  GAGCTGTGTCGCCGGCCTTCCCTGCTGCGGCAGCCACCCCCTACCCGCTGTGACCACGTCCCGCTGCTTG
  CCACCCCCAACCCTGCCCTCTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_016609
• ORF Size: 1563 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_016609.4, NP_057693.3
• RefSeq Size: 2419
• RefSeq ORF: 1563
• Locus ID: 51310
• Protein Families: Druggable Genome, Transmembrane
• Gene Summary: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.