Collagen XI alpha 2 (COL11A2) (NM_080681) Human Untagged Clone

CAT#: SC305815

COL11A2 (untagged)-Human collagen, type XI, alpha 2 (COL11A2), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COL11A2
• Synonyms: DFNA13; DFNB53; FBCG2; HKE5; OSMEDA; OSMEDB; PARP; STL3
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_080681, the custom clone sequence may differ by one or more nucleotides
  ATGGAGCGGTGCAGCCGCTGCCATCGCCTCCTCCTCCTCCTACCTCTGGTGCTGGGGCTG
  AGCGCGGCCCCAGGCTGGGCAGGTGCACCCCCTGTGGATGTGCTCCGGGCCCTGAGGTTC
  CCCTCCCTCCCTGATGGTGTCCGGAGAGCGAAAGGCATCTGTCCAGCTGATGTGGCCTAC
  CGAGTGGCACGACCTGCCCAGCTCAGTGCACCCACTCGCCAGCTTTTCCCAGGAGGATTT
  CCCAAAGATTTCTCTCTGCTGACTGTTGTCCGGACCCGCCCTGGTCTCCAAGCTCCCCTC
  CTGACTCTCTACAGTGCCCAGGGTGTCCGACAGCTGGGCCTGGAGCTGGGCCGACCTGTC
  CGCTTCCTGTATGAAGACCAGACTGGGCGGCCTCAACCTCCCTCTCAGCCAGTCTTCCGA
  GGCCTCAGCCTAGCAGATGGCAAGTGGCACCGTGTGGCTGTGGCTGTGAAGGGCCAGTCT
  GTCACCCTCATTGTTGACTGCAAGAAGCGAGTCACCCGGCCTCTCCCCCGAAGTGCTCGT
  CCAGTATTGGACACCCATGGAGTGATCATCTTTGGTGCCCGTATTCTGGATGAAGAAGTC
  TTTGAGGGTGATGTCCAGGAGCTGGCCATTGTCCCAGGGGTCCAGGCAGCCTATGAATCA
  TGTGAACAGAAGGAGCTGGAATGCGAGGGGGGCCAGAGGGAAAGACCCCAAAACCAACAG
  CCTCACAGAGCCCAGAGATCTCCACAGCAGCAACCATCAAGACTTCACAGGCCACAAAAT
  CAGGAACCCCAGAGCCAGGACCCCACCCCAGGTGAAGAGGAAGAAATCCTGGAGTCGAGC
  CTCTTGCCACCCCTTGAGGAGGCTGCCCATGGACCCCGAGGGCTGAAGGGAGAGAAAGGA
  GAGCCTGCAGTGTTGGAACCTGGTATGCTCGTGGAGGGGCCCCCTGGCCCAGAAGGCCCT
  GCGGGATTGATTGGTCCCCCTGGCATCCAGGGGAACCCAGGCCCAGTTGGAGACCCTGGA
  GAGAGGGGCCCCCCTGGCCGAGCAGGGCTCCCTGGATCAGATGGGGCTCCTGGTCCTCCT
  GGCACATCTCTCATGCTCCCATTCCGGTTTGGCAGTGGTGGGGGTGACAAGGGCCCTGTG
  GTGGCGGCCCAGGAGGCTCAGGCCCAGGCGATCCTGCAGCAGGCGAGGCTGGCGCTCCGT
  GGACCCCCTGGCCCCATGGGATACACAGGGCGCCCTGGACCCTTGGGCCAACCTGGGAGC
  CCTGGCCTGAAAGGAGAGTCTGGAGACTTAGGACCTCAGGGCCCCAGAGGACCTCAGGGC
  CTCACAGGCCCTCCTGGCAAGGCTGGGCGAAGGGGCCGGGCAGGTGCTGATGGAGCCCGA
  GGGATGCCTGGAGATCCTGGAGTGAAGGGTGACCGAGGTTTTGATGGACTCCCAGGGCTC
  CCTGGAGAGAAGGGCCATAGGGGTGATACTGGTGCCCAGGGCCTTCCTGGTCCCCCTGGT
  GAGGATGGAGAGAGGGGAGATGACGGGGAGATTGGGCCTCGAGGGCTGCCTGGAGAGTCG
  GGACCTCGAGGTCTCCTTGGCCCCAAAGGCCCACCTGGTATTCCTGGACCCCCTGGCGTC
  CGAGGCATGGATGGTCCCCAGGGCCCCAAAGGGAGCTTGGGACCCCAGGGAGAGCCAGGA
  CCTCCTGGACAACAGGGCACCCCTGGGACCCAGGGTCTTCCCGGGCCCCAGGGTGCCATC
  GGCCCTCATGGAGAGAAGGGTCCTCAAGGGAAGCCAGGGCTCCCCGGCATGCCTGGCTCA
  GACGGACCCCCGGGTCACCCAGGGAAGGAAGGTCCCCCTGGAACCAAAGGAAACCAGGGT
  CCCTCTGGACCTCAGGGACCTCTAGGATACCCAGGACCTCGAGGGGTCAAGGGTGTGGAC
  GGAATTCGGGGTCTGAAGGGTCATAAGGGTGAGAAGGGTGAGGATGGCTTTCCTGGGTTC
  AAAGGTGACATAGGCGTGAAAGGTGACAGGGGCGAAGTTGGAGTCCCTGGTTCCAGGGGA
  GAGGATGGTCCTGAGGGGCCAAAGGGACGCACTGGACCGACTGGAGACCCTGGGCCCCCA
  GGGCTCATGGGCGAGAAGGGCAAGCTGGGTGTTCCTGGTCTGCCTGGCTATCCTGGACGT
  CAGGGACCCAAGGGGTCCCTAGGATTTCCTGGCTTTCCTGGTGCCAGTGGAGAGAAGGGA
  GCCCGGGGCCTGTCGGGGAAGTCAGGGCCTCGGGGAGAACGGGGCCCCACGGGTCCACGG
  GGTCAGCGGGGACCCCGAGGTGCCACTGGGAAGTCTGGAGCTAAGGGAACATCTGGTGGT
  GATGGCCCCCATGGGCCCCCTGGAGAGAGGGGCCTCCCTGGACCTCAGGGTCCCAACGGG
  TTTCCTGGACCGAAAGGACCCCCGGGCCCCCCTGGGAAGGATGGGCTGCCGGGACACCCA
  GGCCAAAGAGGAGAAGTGGGTTTCCAAGGGAAGACCGGCCCCCCTGGTCCTCCAGGAGTG
  GTGGGACCTCAGGGAGCAGCAGGAGAAACCGGCCCTATGGGGGAGAGAGGTCACCCAGGC
  CCCCCGGGGCCCCCTGGAGAGCAGGGACTACCTGGGACAGCTGGAAAAGAAGGAACAAAG
  GGTGACCCTGGTCCCCCTGGGGCCCCAGGGAAGGATGGTCCTGCTGGTCTGAGGGGATTC
  CCAGGAGAGAGAGGCCTCCCAGGCACTGCTGGTGGACCTGGTTTGAAGGGGAATGAAGGT
  CCGTCTGGCCCCCCTGGCCCTGCAGGCTCCCCTGGGGAACGAGGTGCAGCAGGATCAGGG
  GGACCCATTGGTCCGCCAGGGCGCCCAGGCCCGCAGGGTCCCCCTGGAGCAGCAGGAGAG
  AAAGGTGTCCCAGGTGAGAAGGGCCCCATTGGCCCGACTGGCCGAGATGGAGTGCAGGGT
  CCTGTGGGGCTTCCTGGTCCTGCTGGGCCTCCAGGTGTGGCTGGAGAGGATGGAGACAAG
  GGTGAGGTGGGGGACCCCGGACAGAAGGGCACCAAAGGGAACAAGGGTGAACATGGCCCT
  CCTGGACCCCCTGGACCCATTGGTCCTGTGGGGCAGCCTGGAGCAGCGGGAGCAGATGGG
  GAGCCCGGAGCTCGGGGACCCCAGGGACACTTTGGAGCCAAAGGTGATGAAGGAACAAGA
  GGATTCAATGGGCCCCCAGGACCCATTGGCCTACAGGGTTTGCCAGGCCCCTCTGGGGAG
  AAGGGAGAAACAGGAGATGTGGGTCCTATGGGACCACCTGGCCCCCCAGGACCTCGAGGT
  CCAGCTGGACCCAATGGCGCTGATGGCCCACAAGGTCCCCCAGGAGGTGTTGGGAACCTG
  GGTCCCCCTGGAGAGAAGGGGGAACCAGGAGAGTCAGGATCTCCAGGGATCCAGGGCGAG
  CCAGGTGTCAAGGGTCCACGCGGGGAACGTGGAGAGAAAGGAGAGTCGGGGCAGCCAGGA
  GAGCCAGGGCCACCAGGGCCTAAAGGCCCCACAGGCGATGATGGCCCCAAAGGGAACCCT
  GGTCCTGTTGGTTTTCCTGGTGACCCTGGCCCCCCTGGAGAAGGTGGCCCTCGGGGCCAG
  GATGGTGCTAAGGGTGACCGAGGCGAGGATGGTGAGCCAGGACAGCCTGGATCCCCTGGT
  CCCACCGGGGAGAATGGACCCCCAGGGCCACTTGGAAAGCGAGGTCCTGCTGGCTCGCCT
  GGTTCCGAGGGGCGACAAGGAGGGAAGGGAGCCAAGGGAGATCCTGGCGCTATAGGTGCC
  CCGGGGAAGACAGGCCCGGTGGGTCCTGCAGGCCCAGCAGGGAAACCTGGCCCTGATGGT
  CTGAGGGGGCTCCCAGGCTCAGTGGGTCAGCAAGGCCGACCTGGAGCTACAGGCCAGGCT
  GGGCCCCCAGGTCCTGTGGGACCCCCAGGGCTGCCTGGTCTCCGGGGCGATGCTGGAGCC
  AAGGGAGAGAAGGGCCACCCAGGTCTCATTGGACTGATTGGGCCCCCGGGTGAGCAGGGA
  GAGAAGGGAGATCGGGGACTTCCTGGGCCTCAGGGCTCCCCTGGGCAGAAGGGTGAGATG
  GGTATCCCAGGAGCATCCGGCCCCATTGGTCCTGGAGGTCCCCCCGGCCTCCCCGGACCT
  GCTGGCCCCAAAGGAGCCAAAGGAGCCACAGGCCCAGGCGGACCCAAGGGAGAGAAGGGT
  GTGCAGGGCCCTCCAGGACACCCGGGTCCCCCAGGCGAGGTGATCCAGCCACTGCCCATT
  CAGATGCCCAAGAAGACTCGGCGCTCGGTGGATGGAAGCCGTCTGATGCAGGAAGATGAG
  GCCATACCGACCGGGGGAGCCCCCGGCAGTCCTGGGGGGCTGGAGGAGATCTTTGGCTCA
  CTCGACTCCCTGCGGGAGGAGATCGAGCAGATGAGGCGGCCAACAGGGACCCAGGACAGC
  CCTGCTCGCACCTGCCAGGACCTGAAGCTGTGCCACCCAGAGCTTCCCGATGGAGAGTAC
  TGGGTCGACCCCAACCAGGGCTGTGCTCGGGATGCCTTCCGAGTTTTCTGCAACTTCACA
  GCAGGGGGTGAGACCTGTGTGACGCCTAGGGATGACGTCACGCAGTTCTCTTACGTGGAC
  TCAGAGGGCTCCCCAGTGGGTGTGGTCCAGCTCACCTTCCTGCGGCTGCTCAGCGTCTCA
  GCCCACCAGGACGTCTCCTACCCCTGCTCTGGAGCAGCCCGTGACGGTCCCCTGAGACTC
  CGTGGGGCCAATGAGGATGAGCTGAGCCCGGAGACTAGCCCCTATGTCAAAGAATTCAGA
  GATGGCTGCCAGACACAGCAAGGCCGGACGGTGCTGGAGGTGCGAACGCCTGTGCTGGAG
  CAGCTGCCAGTGCTGGATGCCTCCTTCTCAGACCTGGGAGCCCCACCGAGGCGGGGAGGG
  GTGCTGCTGGGGCCTGTCTGCTTCATGGGATAG
  
• Restriction Sites: Please inquire
• ACCN: NM_080681
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_080681.1, NP_542412.1
• RefSeq Size: 6156 bp
• RefSeq ORF: 4953 bp
• Locus ID: 1302
• Cytogenetics: 6p21.32
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ECM-receptor interaction, Focal adhesion
• Gene Summary: 'This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6. [provided by RefSeq, Jul 2009]'
  Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1. There are no publicly available human transcripts representing the full-length exon combination of this variant, but the region of variation is supported by experimental data in PMIDs 8663204 and 8838804, by homology data in mouse, and the full-length sequence is represented in accession U32169.1:AAC50213.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.