Leucyl cystinyl aminopeptidase (LNPEP) (NM_175920) Human Untagged Clone

CAT#: SC307057

LNPEP (untagged)-Human leucyl/cystinyl aminopeptidase (LNPEP), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LNPEP
• Synonyms: CAP; IRAP; P-LAP; PLAP
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_175920, the custom clone sequence may differ by one or more nucleotides
  ATGATTGAAAACAGCATGTTTGAGGAAGAACCAGATGTGGTGGATTTAGCCAAAGAGCCT
  TGTTTACATCCTCTAGAGCCTGATGAGGTGGAATATGAGCCCCGGGGTTCCCGACTGCTG
  GTGCGGGGTCTTGGTGAGCATGAGATGGAGGAGGATGAAGAGGATTATGAGTCATCAGCA
  AAGCTGCTGGGCATGTCCTTCATGAATAGAAGCTCAGGCCTTCGGAACAGTGCAACTGGT
  TACAGGCAGAGCCCAGATGGGGCTTGTTCAGTACCCTCTGCAAGGACCATGGTGGTCTGT
  GCTTTTGTCATCGTGGTTGCTGTTTCTGTAATCATGGTGATTTACTTACTGCCCAGATGT
  ACCTTTACCAAAGAAGGCTGCCATAAAAAAAACCAGTCAATTGGACTAATTCAGCCATTT
  GCAACAAATGGGAAATTGTTTCCATGGGCACAGATCAGGCTTCCCACTGCCGTTGTGCCA
  CTACGCTATGAACTCAGCCTACACCCGAACCTAACCTCGATGACATTCAGGGGTTCTGTG
  ACAATTTCAGTTCAGGCTCTTCAGGTCACATGGAATATCATTCTTCATAGCACAGGTCAT
  AATATTTCAAGAGTGACCTTTATGTCAGCAGTTTCAAGCCAAGAAAAACAAGCTGAGATC
  CTGGAATATGCATATCATGGACAGATCGCCATTGTTGCCCCCGAAGCCCTTCTAGCAGGG
  CACAATTATACGTTGAAGATAGAGTACTCGGCAAATATATCTAGTTCTTATTATGGGTTT
  TATGGCTTCTCCTACACAGATGAAAGTAATGAGAAAAAGTACTTTGCAGCAACTCAGTTT
  GAACCCCTGGCAGCAAGATCTGCTTTTCCTTGTTTTGATGAACCAGCATTTAAAGCCACT
  TTTATCATCAAGATCATAAGGGATGAGCAATACACCGCTTTATCAAATATGCCTAAGAAG
  TCATCAGTCGTTCTAGATGATGGACTTGTTCAGGATGAGTTTTCTGAGAGTGTGAAGATG
  AGCACTTACTTGGTTGCTTTCATTGTGGGAGAGATGAAGAACCTGAGTCAGGACGTAAAT
  GGAACCCTGGTTTCTATATATGCTGTACCAGAAAAGATTGGTCAAGTTCATTATGCCTTG
  GAAACAACTGTGAAGCTTCTTGAGTTTTTTCAAAACTACTTTGAAATTCAGTACCCACTT
  AAGAAATTGGATTTGGTGGCTATTCCTGACTTTGAAGCAGGAGCAATGGAAAATTGGGGT
  TTGCTCACCTTCCGAGAGGAGACACTTCTGTATGACAGTAACACTTCTTCAATGGCGGAT
  AGAAAGCTGGTGACTAAAATCATTGCTCATGAGCTGGCCCACCAGTGGTTTGGCAATCTG
  GTAACAATGAAGTGGTGGAATGACCTATGGCTAAATGAAGGTTTTGCCACTTTCATGGAG
  TATTTCTCTTTGGAAAAAATATTCAAAGAGCTTTCTAGTTATGAAGATTTCTTAGATGCT
  CGATTTAAAACCATGAAGAAAGATTCCTTAAATTCATCTCATCCAATATCATCATCTGTT
  CAGTCTTCAGAACAAATTGAAGAAATGTTTGATTCTCTTTCCTATTTTAAGGGATCTTCT
  CTCTTGTTGATGTTGAAAACTTACCTTAGTGAAGATGTGTTTCAACATGCTGTTGTCCTT
  TACCTGCATAATCACAGCTATGCATCTATTCAAAGTGATGATCTGTGGGATAGTTTTAAT
  GAGGTCACAAACCAAACACTAGATGTAAAGAGAATGATGAAAACCTGGACCCTGCAGAAA
  GGATTTCCTTTAGTGACTGTTCAAAAGAAAGGAAAGGAACTTTTTATACAACAAGAGAGA
  TTCTTTTTAAATATGAAGCCTGAAATTCAGCCTTCAGATACAAGCTACCTGTGGCATATT
  CCACTATCCTATGTCACTGAAGGAAGAAATTATTCAAAATATCAATCGGTATCATTACTG
  GATAAGAAATCAGGTGTCATCAATCTTACAGAAGAAGTGCTGTGGGTCAAAGTGAATATA
  AACATGAATGGTTATTATATTGTACACTATGCAGATGATGATTGGGAAGCACTAATCCAT
  CAGTTGAAAATAAATCCTTATGTTCTGAGTGACAAAGACCGAGCCAACCTTATCAACAAC
  ATCTTTGAACTTGCAGGCCTAGGCAAGGTACCTCTCAAGAGGGCCTTTGATTTGATTAAT
  TATCTTGGAAATGAGAACCATACTGCACCCATCACCGAAGCCCTGTTTCAGACAGACCTC
  ATCTATAACCTCCTTGAAAAACTGGGATACATGGATCTGGCCTCAAGACTGGTGACTAGG
  GTATTTAAATTACTTCAAAACCAAATTCAACAACAAACTTGGACTGATGAGGGCACTCCA
  TCTATGCGAGAGCTTCGGTCAGCCCTGCTAGAGTTTGCTTGCACCCACAACCTGGGGAAC
  TGCTCTACTACTGCCATGAAACTGTTTGATGACTGGATGGCATCCAATGGAACTCAAAGC
  CTACCTACTGATGTCATGACAACTGTGTTCAAAGTTGGAGCAAAAACTGACAAAGGCTGG
  TCATTCCTTTTGGGCAAATACATTTCTATAGGCTCTGAAGCAGAGAAGAACAAAATACTA
  GAAGCACTTGCCAGCTCAGAGGATGTGCGGAAGCTTTACTGGTTAATGAAAAGTAGCCTG
  AATGGAGATAACTTCCGAACACAGAAGCTGTCTTTTATCATTAGAACAGTGGGTCGACAT
  TTTCCTGGACACTTACTGGCATGGGATTTTGTCAAAGAGAACTGGAATAAGCTTGTACAG
  AAGTTCCCTCTGGGGTCCTATACCATACAAAATATTGTTGCTGGATCAACTTACCTGTTT
  TCAACAAAGACACATTTATCTGAGGTTCAGGCATTCTTTGAAAATCAGTCAGAGGCAACC
  TTCCGGCTTCGTTGTGTCCAGGAGGCTTTGGAAGTCATTCAGTTGAATATCCAGTGGATG
  GAGAAGAACCTCAAAAGTCTCACATGGTGGCTGTAG
  
• Restriction Sites: Please inquire
• ACCN: NM_175920
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_175920.3, NP_787116.2
• RefSeq Size: 4262 bp
• RefSeq ORF: 3036 bp
• Locus ID: 4012
• Cytogenetics: 5q15
• Protein Families: Druggable Genome, Protease, Secreted Protein, Transmembrane
• Protein Pathways: Renin-angiotensin system
• Gene Summary: 'This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]'
  Transcript Variant: This variant (2) contains an alternate 5' exon, which results in a distinct 5' UTR and use of a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.