APC2 (NM_005883) Human Untagged Clone

CAT#: SC308971

APC2 (untagged)-Human adenomatosis polyposis coli 2 (APC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: APC2
• Synonyms: APCL
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005883, the custom clone sequence may differ by one or more nucleotides
  ATGGCGAGCTCCGTGGCGCCCTACGAGCAGCTGGTGAGGCAGGTGGAGGCCTTGAAGGCT
  GAGAACAGCCACCTGAGGCAGGAGCTAAGGGACAACTCCAGCCACCTGTCCAAGCTGGAG
  ACAGAGACGTCGGGCATGAAGGAGGTCCTGAAGCACCTACAGGGAAAACTGGAGCAGGAG
  GCCCGAGTGCTGGTGTCCTCGGGGCAGACGGAGGTGCTGGAGCAGCTGAAGGCCCTACAG
  ATGGACATCACCAGCCTGTACAACCTCAAGTTCCAGCCGCCCACCCTGGGCCCGGAGCCT
  GCCGCCCGGACCCCCGAGGGCAGCCCAGTACACGGCTCCGGGCCCTCCAAGGACAGCTTT
  GGGGAGCTGAGCCGGGCCACCATCCGGCTGCTGGAGGAACTGGACCGGGAACGGTGTTTC
  CTGCTGAATGAGATTGAGAAGGAGGAGAAGGAGAAGCTCTGGTACTACTCTCAGCTGCAG
  GGCCTGTCCAAGCGCCTGGACGAGCTGCCGCACGTGGAGACGCAGTTCTCGATGCAGATG
  GACCTGATCCGGCAGCAGCTTGAGTTCGAGGCCCAGCACATCCGCTCGCTGATGGAGGAG
  CGCTTCGGCACCTCGGACGAGATGGTGCAGCGGGCACAGATCCGCGCCTCGCGCCTGGAG
  CAGATTGACAAGGAGCTGCTGGAGGCGCAGGACCGAGTGCAGCAGACGGAGCCCCAGGCC
  TTGCTGGCGGTGAAGTCGGTGCCGGTGGACGAGGACCCCGAGACAGAGGTCCCCACACAC
  CCTGAGGATGGCACCCCTCAGCCGGGCAACAGCAAGGTGGAGGTGGTCTTCTGGCTGTTG
  TCCATGTTGGCGACGCGCGACCAGGAGGATACAGCGCGCACGCTGCTGGCCATGTCCAGC
  TCGCCCGAGAGCTGCGTGGCCATGCGCCGCTCGGGCTGTCTGCCTCTGCTGCTGCAAATC
  CTCCACGGCACCGAGGCCGCGGCCGGGGGTCGCGCCGGGGCCCCAGGGGCACCGGGCGCC
  AAGGACGCACGCATGCGCGCCAACGCGGCGCTGCACAACATCGTCTTCTCGCAGCCGGAC
  CAGGGCCTGGCGCGCAAGGAGATGCGCGTCCTGCACGTGCTGGAGCAGATCCGGGCCTAC
  TGCGAGACCTGCTGGGACTGGCTGCAGGCCCGAGACGGCGGGCCCGAGGGAGGTGGCGCC
  GGCAGCGCCCCGATCCCCATCGAGCCGCAGATCTGCCAGGCCACCTGTGCTGTTATGAAG
  CTGTCCTTTGATGAGGAGTACCGCCGTGCCATGAACGAGCTAGGTGGGCTGCAGGCCGTG
  GCAGAGCTGCTGCAGGTTGACTATGAGATGCACAAGATGACCCGGGACCCGCTGAACCTG
  GCGCTGCGCCGCTACGCGGGCATGACCCTCACCAACCTCACCTTTGGGGACGTTGCCAAC
  AAGGCCACCCTGTGTGCGCGCCGCGGCTGCATGGAGGCCATCGTGGCCCAGCTGGCCTCC
  GACAGTGAGGAGCTCCACCAGGTGGTGTCCAGCATCCTTCGGAACTTGTCCTGGAGGGCC
  GACATCAACAGCAAGAAGGTGCTGAGGGAGGCGGGCAGCGTGACTGCCCTGGTGCAGTGT
  GTCCTGCGGGCCACCAAGGAGTCCACCCTGAAGAGCGTGCTGAGCGCCCTGTGGAATCTG
  TCTGCACACAGCACAGAGAACAAGGCGGCCATCTGCCAGGTGGATGGCGCCCTGGGCTTC
  CTGGTGAGCACCCTGACCTACAAGTGTCAGAGCAACTCGCTGGCCATCATCGAGAGCGGC
  GGCGGCATCCTCCGCAATGTGTCCAGCCTCGTCGCCACCCGTGAGGACTACAGGCAGGTG
  CTCCGGGATCACAACTGTCTGCAGACGCTGCTGCAGCATCTGACTTCGCACAGCCTGACC
  ATCGTGAGCAACGCGTGCGGCACGCTCTGGAACCTGTCGGCCCGCAGCGCCCGTGACCAG
  GAGCTGCTGTGGGACCTGGGCGCCGTGGGCATGCTGCGTAATCTGGTGCACTCCAAGCAC
  AAGATGATCGCCATGGGCAGCGCCGCCGCCCTGCGCAACCTGCTGGCCCATCGGCCCGCC
  AAGCACCAGGCGGCCGCCACCGCCGTGTCCCCAGGCAGCTGCGTGCCCAGCCTGTACGTG
  CGCAAGCAGCGGGCGCTGGAGGCCGAGCTGGACGCACGGCACCTCGCGCAGGCGCTGGAG
  CACCTGGAGAAGCAGGGCCCGCCGGCAGCCGAGGCCGCCACTAAGAAGCCGCTGCCGCCC
  CTGCGACACCTGGACGGCCTGGCCCAAGACTATGCTTCCGATTCGGGCTGCTTTGACGAC
  GACGATGCACCGTCATCCCTGGCTGCGGCCGCGGCCACCGGGGAGCCAGCCAGCCCTGCC
  GCGCTGTCCCTCTTCCTGGGCAGCCCCTTCCTGCAGGGGCAGGCGCTGGCTCGCACCCCG
  CCCACCCGCCGAGGCGGCAAGGAGGCAGAGAAGGACACCAGTGGGGAGGCAGCCGTGGCG
  GCCAAGGCCAAGGCCAAGCTGGCGCTTGCAGTGGCGCGCATCGACCAGCTGGTGGAGGAC
  ATCTCCGCCCTGCACACCTCGTCCGACGATAGCTTCAGCCTCAGCTCTGGAGACCCGGGA
  CAGGAGGCGCCACGGGAGGGCCGCGCCCAGTCCTGCTCGCCATGCCGCGGCCCGGAGGGC
  GGGCGGCGAGAGGCAGGAAGCCGGGCGCACCCGCTGCTGCGGCTCAAGGCGGCCCACGCC
  AGCCTCTCCAACGACAGCCTCAACAGCGGCAGTGCCAGCGACGGGTACTGCCCACGCGAA
  CATATGCTGCCCTGCCCGCTGGCCGCACTGGCTTCGCGCCGCGAGGACCCCAGGTGTGGG
  CAGCCTCGGCCCAGCCGGCTTGACCTTGACCTGCCCGGCTGCCAGGCCGAGCCCCCGGCC
  CGCGAGGCCACCTCCGCCGACGCCCGCGTGCGCACCATCAAGCTGTCGCCTACCTATCAG
  CACGTGCCACTGCTTGAGGGTGCCTCAAGGGCGGGTGCAGAGCCCCTCGCGGGGCCTGGA
  ATCTCTCCAGGGGCCCGGAAGCAGGCCTGGCTGCCGGCAGACCACCTGAGCAAGGTTCCC
  GAGAAGCTGGCGGCTGCCCCGCTGTCTGTGGCCAGCAAGGCACTGCAGAAACTGGCGGCG
  CAAGAGGGGCCACTCTCGCTGTCCCGATGCAGCTCCCTTTCCTCGCTGTCCTCGGCCGGC
  CGCCCAGGCCCCAGCGAGGGTGGTGACCTGGATGACAGTGACTCCTCCCTGGAGGGGCTG
  GAGGAGGCCGGCCCCAGCGAGGCTGAGCTGGACAGCACGTGGCGGGCGCCCGGGGCCACC
  TCGCTGCCCGTAGCCATTCCGGCTCCCCGGCGTAACCGAGGCCGGGGCCTGGGGGTGGAA
  GACGCCACGCCGTCCAGCTCGTCGGAGAACTACGTGCAGGAGACACCGCTTGTGCTGAGC
  CGCTGCAGCTCTGTGAGCTCGCTGGGCAGCTTCGAGAGCCCGTCCATCGCCAGCTCCATC
  CCCAGTGAACCTTGCAGCGGGCAGGGCAGCGGCACCATCAGCCCTAGCGAGCTGCCCGAC
  AGCCCCGGACAGACCATGCCTCCCAGCCGGAGCAAGACGCCACCGCTGGCGCCCGCGCCA
  CAGGGTCCCCCCGAGGCCACCCAGTTCAGCCTGCAGTGGGAGAGCTACGTGAAGCGCTTC
  CTGGACATCGCCGACTGCCGGGAGCGCTGCCGGCTGCCATCTGAGCTGGACGCAGGCAGC
  GTGCGCTTTACCGTGGAGAAGCCAGACGAGAACTTCTCGTGCGCCTCCAGCCTCAGCGCG
  CTGGCCTTGCACGAGCACTACGTGCAGCAGGACGTGGAGCTGCGGCTGCTGCCCTCGGCC
  TGCCCCGAGCGCGGCGGGGGCGCCGGGGGCGCCGGCCTCCACTTTGCAGGGCACCGGCGG
  CGGGAGGAGGGGCCGGCGCCCACGGGTTCTCGCCCTCGCGGCGCCGCGGACCAGGAGCTG
  GAACTGCTGCGGGAGTGCCTGGGAGCCGCCGTGCCTGCCCGGCTGCGCAAGGTGGCCTCC
  GCGCTGGTGCCAGGTCGCCGCGCACTCCCCGTGCCCGTCTACATGTTGGTGCCCGCCCCG
  GCCCCGGCCCAGGAGGACGACTCCTGCACTGACTCCGCGGAGGGCACGCCGGTCAACTTC
  TCTAGCGCCGCCTCGCTCAGCGACGAGACGCTGCAGGGACCCCCCAGGGACCAGCCCGGG
  GGACCAGCGGGCAGGCAAAGACCCACCGGCCGCCCCACCTCTGCCAGACAGGCCATGGGG
  CACCGGCACAAGGCGGGAGGCGCCGGCCGCAGCGCGGAGCAGTCTCGGGGCGCGGGCAAG
  AACAGAGCAGGGCTGGAGCTGCCCCTGGGCCGGCCCCCGAGCGCCCCCGCAGACAAGGAC
  GGCTCAAAGCCCGGCCGGACCCGCGGGGACGGGGCGCTCCAGTCGCTGTGCCTCACGACG
  CCCACTGAGGAGGCCGTGTACTGCTTCTACGGCAACGACTCGGACGAGGAGCCCCCGGCG
  GCCGCGCCCACGCCAACCCACCGGCGCACATCGGCCATCCCTCGCGCTTTTACGCGGGAG
  CGTCCGCAGGGCCGGAAGGAGGCCCCTGCCCCGTCCAAGGCTGCACCAGCTGCCCCGCCG
  CCCGCCCGGACCCAGCCCAGCCTCATTGCTGACGAGACCCCGCCCTGCTACTCCCTGAGC
  TCCTCCGCCAGCTCCCTCAGCGAGCCCGAGCCCTCGGAGCCGCCGGCCGTCCATCCACGA
  GGCCGGGAGCCCGCGGTCACCAAGGACCCGGGCCCAGGAGGCGGACGCGACAGCTCGCCC
  AGCCCGCGGGCCGCGGAGGAGCTTCTGCAGCGGTGCATCAGCTCGGCCCTGCCCAGGCGC
  CGGCCCCCCGTGTCTGGCCTGCGGCGCCGCAAGCCCCGAGCCACCCGGCTGGATGAGCGG
  CCCGCAGAGGGGTCCCGGGAACGCGGCGAGGAGGCAGCGGGCTCGGACCGGGCCTCCGAC
  CTGGATAGCGTGGAGTGGCGCGCCATCCAGGAGGGCGCCAATTCAATTGTCACGTGGCTG
  CACCAGGCAGCAGCTGCCACGCGGGAGGCCTCGTCCGAGTCCGACTCCATCCTGTCCTTC
  GTATCCGGGCTGTCAGTGGGATCCACCCTACAGCCCCCCAAGCACAGGAAGGGACGACAG
  GCGGAGGGAGAAATGGGCAGTGCCCGGCGGCCAGAGAAAAGGGGCGCAGCCTCAGTCAAG
  ACCAGCGGGAGCCCCCGTTCCCCTGCAGGCCCCGAGAAGCCACGTGGCACACAGAAGACC
  ACGCCCGGGGTGCCAGCTGTGCTCCGGGGACGAACAGTGATCTACGTCCCCAGCCCGGCA
  CCCCGTGCCCAGCCCAAAGGGACCCCCGGCCCCCGCGCCACACCGCGGAAGGTGGCGCCC
  CCTTGCCTGGCACAGCCCGCGGCTCCAGCCAAAGTCCCGAGCCCCGGGCAGCAGCGGTCG
  CGGAGCCTACACCGGCCTGCCAAGACCTCGGAGCTGGCGACGCTGAGCCAGCCCCCCAGA
  AGCGCCACACCGCCCGCCCGCCTCGCCAAGACCCCCTCCTCCAGCTCCTCCCAGACCTCG
  CCCGCCTCCCAGCCCCTGCCCAGAAAGCGCCCCCCGGTCACCCAGGCTGCTGGGGCCCTG
  CCCGGCCCCGGAGCCTCCCCGGTGCCCAAAACGCCGGCGCGCACCCTTCTGGCGAAGCAG
  CACAAGACGCAGAGATCGCCCGTGCGGATCCCGTTCATGCAGAGGCCGGCCCGGCGTGGG
  CCGCCACCGCTGGCTCGGGCAGTCCCGGAGCCGGGCCCCAGGGGCCGGGCGGGGACCGAG
  GCGGGCCCGGGGGCGCGCGGGGGCCGCCTGGGCCTGGTGCGTGTGGCCTCAGCCCTCTCC
  AGCGGCAGCGAGTCCTCCGACCGCTCGGGCTTCCGGCGACAGCTAACCTTCATCAAGGAG
  TCGCCGGGCTTGCGGCGCCGCCGCTCCGAGCTGTCCTCGGCCGAGTCCGCGGCCTCTGCC
  CCCCAGGGCGCCTCGCCCCGCCGCGGCCGGCCCGCGCTGCCCGCCGTCTTCCTCTGCTCC
  TCGCGCTGCGAAGAGCTCCGAGCGGCACCCCGGCAGGGCCCGGCCCCGGCCCGGCAGCGG
  CCCCCCGCGGCCCGACCCAGCCCTGGCGAGCGCCCTGCCCGGCGCACCACCTCCGAGAGC
  CCGTCCCGCCTGCCTGTGCGCGCGCCCGCCGCCCGGCCGGAGACTGTCAAGCGCTACGCG
  TCGCTGCCGCACATCAGCGTGGCCCGCAGGCCCGACGGCGCCGTCCCCGCGGCCCCTGCC
  TCAGCCGACGCCGCGCGCCGCAGCAGCGACGGGGAGCCCCGGCCGCTCCCCAGGGTGGCC
  GCGCCGGGCACGACCTGGCGGCGCATCCGAGATGAGGACGTGCCCCACATCCTGCGCAGC
  ACGCTTCCCGCCACGGCCCTGCCACTGCGGGGCTCCACGCCCGAGGACGCCCCGGCCGGG
  CCCCCGCCGCGCAAGACCAGCGACGCCGTGGTCCAGACCGAGGAGGTCGCCGCCCCCAAG
  ACCAACTCCAGCACGTCCCCGAGCCTGGAGACCAGGGAGCCCCCCGGGGCCCCCGCCGGC
  GGCCAGCTCTCCCTCCTCGGCAGCGACGTGGACGGTCCCAGCCTCGCCAAGGCTCCCATC
  TCCGCACCCTTCGTGCACGAGGGCCTGGGGGTCGCCGTGGGGGGCTTCCCCGCCAGCCGG
  CACGGCTCCCCCAGCCGCTCGGCCCGAGTACCCCCCTTCAACTATGTGCCCAGCCCCATG
  GTGGTCGCAGCCACCACCGACTCGGCCGCGGAGAAAGCCCCGGCCACTGCCTCCGCCACC
  CTCCTGGAATAG
  
• Restriction Sites: Please inquire
• ACCN: NM_005883
• ORF Size: 6912 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005883.2, NP_005874.1
• RefSeq Size: 10151
• RefSeq ORF: 6912
• Locus ID: 10297
• Domains: Armadillo_seg
• Protein Families: Druggable Genome
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway
• Gene Summary: This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
  Transcript Variant: This variant (1) encodes the longer isoform (1).