PAPP A (PAPPA) (NM_002581) Human Untagged Clone

CAT#: SC309898

PAPPA (untagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA)


  "NM_002581" in other vectors (6)

Reconstitution Protocol

SC309898 is the updated version of SC125585.

USD 1,100.00

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Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol PAPPA
Synonyms ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1
Vector pCMV6-XL5
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene sequence for NM_002581 edited
AACCGTCGGACATGCGGCTCTGGAGTTGGGTGCTGCACCTGGGGCTGCTGAGCGCCGCGC
TGGGCTGCGGGCTGGCCGAGCGTCCCCGCCGGGCCCGGAGAGACCCGCGGGCCGGCCGAC
CCCCGCGCCCCGCCGCCGGCCCGGCCACCTGCGCCACCCGGGCGGCCCGCGGCCGCCGCG
CCTCGCCGCCGCCGCCGCCGCCGCCGGGCGGTGCCTGGGAAGCCGTGCGCGTCCCCCGGC
GGCGGCAGCAGCGGGAGGCGAGGGGCGCCACCGAGGAGCCGAGCCCGCCGAGCCGGGCGC
TCTATTTCAGCGGGCGAGGCGAGCAGCTGCGCCTCCGGGCCGACCTCGAGCTGCCCCGGG
ACGCGTTCACGCTGCAAGTGTGGCTGCGAGCGGAGGGGGGCCAGAGGTCTCCGGCAGTGA
TCACAGGGCTGTATGACAAATGTTCTTATATCTCACGTGACCGAGGATGGGTCGTGGGCA
TTCACACCATCAGTGACCAAGACAACAAAGACCCACGCTACTTTTTCTCCTTGAAGACAG
ACCGAGCCCGGCAAGTGACCACCATCAATGCCCACCGCAGCTACCTCCCAGGCCAGTGGG
TATACCTAGCTGCCACCTATGATGGGCAGTTCATGAAGCTCTATGTGAATGGTGCCCAGG
TGGCCACCTCTGGGGAACAAGTGGGTGGCATATTCAGCCCACTGACCCAGAAGTGCAAAG
TGCTCATGTTAGGGGGCAGTGCCCTGAATCACAACTACCGGGGCTACATCGAGCACTTCA
GTCTGTGGAAGGTGGCCAGGACTCAGCGGGAGATACTGTCTGACATGGAAACCCATGGCG
CCCACACTGCTCTACCTCAGCTCCTCCTCCAGGAGAACTGGGACAATGTGAAGCATGCCT
GGTCCCCCATGAAGGATGGCAGCAGCCCCAAAGTGGAATTCAGCAATGCCCACGGCTTTC
TGCTGGACACGAGTCTGGAGCCTCCTCTGTGTGGACAGACATTGTGTGACAACACAGAGG
TCATTGCCAGCTACAATCAGCTCTCAAGTTTCCGCCAGCCCAAGGTGGTGCGCTACCGCG
TGGTCAACCTCTATGAAGATGATCATAAGAACCCGACGGTGACGCGCGAGCAGGTGGACT
TCCAGCACCATCAGCTGGCTGAGGCCTTCAAGCAATACAACATCTCCTGGGAGCTGGACG
TGCTGGAGGTGAGCAACTCCTCTCTTCGCCGCCGCCTCATCCTGGCCAACTGTGACATCA
GCAAGATTGGGGATGAGAACTGTGACCCCGAGTGCAACCACACGCTGACGGGCCACGACG
GCGGGGATTGCCGCCACCTGCGCCACCCTGCCTTCGTGAAGAAGCAGCACAACGGGGTGT
GTGACATGGACTGCAACTATGAACGGTTCAACTTTGATGGTGGAGAGTGCTGTGACCCTG
AAATCACCAATGTCACTCAGACTTGCTTTGACCCCGACTCTCCACACAGAGCCTACTTGG
ATGTTAATGAGCTGAAGAACATTCTTAAATTGGATGGATCAACACATCTCAATATTTTCT
TTGCAAAATCCTCAGAGGAGGAGTTGGCAGGAGTAGCAACTTGGCCATGGGACAAGGAGG
CCCTGATGCACTTAGGTGGCATTGTCTTGAACCCATCTTTCTATGGCATGCCTGGGCACA
CCCACACCATGATCCATGAGATTGGTCACAGCCTGGGCCTCTATCACGTCTTCCGAGGCA
TCTCAGAAATCCAGTCCTGCAGTGACCCCTGCATGGAGACAGAGCCCTCCTTCGAGACTG
GAGACCTCTGCAATGATACCAACCCAGCCCCTAAACACAAGTCCTGTGGTGACCCAGGGC
CAGGAAATGACACCTGTGGCTTTCATAGCTTCTTCAACACTCCTTACAACAACTTCATGA
GCTATGCAGATGACGACTGTACGGACTCCTTCACGCCCAATCAAGTCGCCAGAATGCACT
GTTACCTGGACCTGGTCTACCAGGGCTGGCAGCCCTCCAGGAAACCAGCGCCTGTTGCCC
TCGCCCCCCAAGTTCTGGGCCACACAACGGACTCTGTGACACTGGAGTGGTTCCCACCTA
TAGATGGCCATTTCTTTGAAAGAGAATTGGGATCAGCATGTCATCTTTGCCTGGAAGGGA
GAATCCTGGTGCAGTATGCTTCCAACGCTTCCTCCCCAATGCCCTGCAGCCCATCAGGAC
ACTGGAGCCCTCGTGAAGCAGAAGGTCATCCTGATGTTGAACAGCCCTGTAAGTCCAGTG
TCCGCACCTGGAGCCCAAATTCAGCTGTCAACCCACACACGGTTCCTCCAGCCTGCCCTG
AGCCTCAAGGCTGCTACCTCGAGCTGGAGTTCCTCTACCCCTTGGTCCCTGAGTCTCTGA
CCATTTGGGTGACCTTTGTCTCCACTGACTGGGACTCTAGTGGAGCTGTCAATGACATCA
AACTGTTGGCTGTCAGTGGGAAGAACATCTCCCTGGGTCCTCAGAATGTCTTCTGTGATG
TCCCACTGACCATCAGACTCTGGGACGTGGGCGAGGAGGTGTATGGCATCCAAATCTACA
CGCTGGATGAGCACCTGGAGATCGATGCTGCCATGTTGACCTCCACTGCAGACACCCCAC
TCTGTCTACAGTGTAAGCCCCTGAAGTATAAGGTGGTCCGGGACCCTCCTCTCCAGATGG
ATGTGGCCTCCATCCTACATCTCAATAGGAAATTCGTAGACATGGATCTAAATCTTGGCA
GTGTGTACCAGTATTGGGTCATAACTATTTCAGGAACTGAAGAGAGTGAGCCATCACCTG
CTGTCACATACATCCATGGAAGTGGGTACTGTGGCGATGGCATTATACAAAAAGACCAAG
GTGAACAATGCGACGACATGAATAAGATCAATGGTGATGGCTGCTCCCTTTTCTGCCGAC
AAGAAGTCTCCTTCAATTGTATTGATGAACCCAGCCGGTGCTATTTCCATGATGGTGATG
GGGTATGTGAGGAGTTTGAACAAAAAACCAGCATTAAGGACTGTGGTGTCTACACGCCCC
AGGGATTCCTGGATCAGTGGGCATCCAATGCTTCAGTATCTCATCAAGACCAGCAATGCC
CAGGCTGGGTCATCATCGGACAGCCAGCAGCATCCCAGGTGTGTCGAACCAAGGTGATAG
ATCTCAGTGAAGGCATTTCCCAGCATGCCTGGTACCCTTGCACCATCAGCTACCCATATT
CCCAGCTGGCTCAGACCACTTTTTGGCTCCGGGCGTATTTTTCTCAACCAATGGTTGCCG
CAGCTGTCATTGTCCACCTGGTGACGGATGGGACATATTATGGGGACCAAAAGCAGGAGA
CCATCAGCGTGCAGCTGCTTGATACCAAAGATCAGAGCCACGATCTAGGCCTCCATGTCC
TGAGCTGCAGGAACAATCCCCTGATTATCCCTGTGGTCCATGACCTCAGCCAGCCCTTCT
ACCACAGCCAGGCGGTACGTGTGAGCTTCAGTTCGCCCCTGGTCGCCATCTCGGGGGTGG
CCCTCCGTTCCTTCGACAACTTTGACCCCGTCACCCTGAGCAGCTGCCAGAGAGGGGAGA
CCTACAGCCCTGCCGAGCAGAGCTGCGTGCACTTCGCATGTGAGAAAACTGACTGTCCAG
AGCTGGCTGTGGAGAATGCTTATCTCAATTGCTCCAGCAGCGACCGCTACCACGGTGCCC
AGTGTACTGTGAGCTGCCGGACAGGCTACGTGCTCCAGATACGGCGGGATGATGAGCTGA
TCAAGAGCCAGACGGGACCCAGCGTCACAGTGACCTGTACAGAGGGCAAGTGGAATAAGC
AGGTGGCCTGTGAGCCAGTCGACTGCAGCATCCCAGATCACCATCAAGTCTATGCTGCCT
CCTTCTCCTGCCCTGAGGGCACCACCTTTGGCAGTCAATGTTCCTTCCAGTGCCGTCACC
CTGCACAATTGAAAGGCAACAACAGCCTCCTGACCTGCATGGAGGATGGGCTGTGGTCCT
TCCCAGAGGCCCTGTGTGAGCTCATGTGCCTCGCTCCACCCCCTGTGCCCAATGCAGACC
TCCAGACCGCCCGGTGCCGAGAGAATAAGCACAAGGTGGGCTCCTTCTGCAAATACAAAT
GCAAGCCTGGATACCATGTGCCTGGATCCTCTCGGAAGTCAAAGAAACGGGCCTTCAAGA
CTCAGTGTACCCAGGATGGCAGCTGGCAGGAGGGAGCTTGTGTTCCTGTGACCTGTGACC
CACCTCCACCAAAATTCCATGGGCTCTACCAGTGTACTAATGGCTTCCAGTTCAACAGTG
AGTGTAGGATCAAGTGTGAAGACAGTGATGCCTCCCAGGGACTTGGGAGCAATGTCATTC
ATTGCCGGAAAGATGGCACCTGGAACGGCTCCTTCCATGTCTGCCAGGAGATGCAAGGCC
AGTGCTCGGTTCCAAACGAGCTCAACAGCAACCTCAAACTGCAGTGCCCTGATGGCTATG
CCATAGGGTCGGAGTGTGCCACCTCGTGCCTGGACCACAACAGCGAGTCCATCATCCTGC
CAATGAACGTGACCGTGCGTGACATCCCCCACTGGCTGAACCCCACACGGGTAGAGAGAG
TTGTCTGCACTGCTGGTCTCAAGTGGTATCCTCACCCTGCTCTGATTCACTGTGTCAAAG
GCTGTGAGCCCTTCATGGGAGACAATTATTGTGATGCCATCAACAACCGAGCCTTTTGCA
ACTATGACGGTGGGGATTGCTGCACCTCCACAGTGAAGACCAAAAAGGTCACCCCATTCC
CTATGTCCTGTGACCTACAAGGTGACTGTGCTTGTCGGGACCCCCAGGCCCAAGAACACA
GCCGGAAAGACCTCCAGGGATACAGCCATGGCTAAGGAAGGACAAGAAGTTGTCAAAGAA
TTCCCAACGCCAGGACCCACATCCCTTTGGTATTGATTTCACAGTCAGCTGCTCAACGGA
ATGGCCTCTCCACACCAGGGATCCTTAGCACCCAACCGGTCTGCCCTTAATTTTACCCAG
GAAGGACTCACATTGGGGCGAATGAACCAAGTTTCGCCATGCTGGATGATGAAATGGATT
CCCATCCCAAAGTCTGAGATGGATTGCATATACAGTGTGCAGTCCCAGAGCCTCCTAAAA
TTCTAGCCATTTGTCACACAACCACAGCAAGAAACGTGTTCTATATCTAGAGTGTGCCCA
TCTGTGTTTAGTACACATGCATGCATACACACCCATACAAACATCTGTGTGAGGGCAGTT
CTGGAGATGAGCAGAGAGAGACCGGAATAAACTCAATCTTTTCTTTCCCAAGCTCCTAGC
CAACACTATCCTTGGGAGAAAGGAATTTGCAGAAACTGCTAAGACCAAGTGTGGAGATGT
CAAGCTAGTTCACACTCTGAGGCTCAGAATATGTAGGACATGCACAATTGTGCAGTCCTT
TGGGATTGGAAGTGAAACAGTCTGTGATCCCCTACCTTCTAGGGAACTAGGACCTAGGAA
GAGGTAAAGATTATCAGGTATGCAAAGCGCCCCAATTCTTCTGCTGCCATGGGGGATTTT
ACCCCAACTCCAGGGTTCGAGGCCAATCTGAGAATGGCTTAGGATTGCAATGTCAAGGTA
TTATATCAGCCCCTTGCTTGAGGCTTGAGGTCATAATATCCCTCTAGGACTTACCTGTTC
CCCCAGATCTTGCCTTGGGACCACATTTGCTGCTACTTTTCCTGCTGCTCTATCCTATAC
ATTGAATAATCCAAGATGGTAGAACTAGGTTAGGAAAAATTCCACACAACCAAACAGTCT
GCCTTAAAAGTGACCCACATTTTTCCATAGCTCCTCACTTTTTAGCCCTTCTGCAAGAGA
AAAACCCTCATGGGTCCACATGGTGAGAAGTTAAGTTTCCTGTAAGTGGGCCTCTCACCC
TGGAAAGGAGTTGAGGGACATCAGATGCTGGAACCCTCACTGAAAGTCCAGAATGTCTAA
GCCAGTGTTAGATTTTGTAAACAAGTGGAACAGTGTTAAATTTCTATGATGTTGGAGCCA
TCCAGAGACTACTGGAATTGTCGAGACTTTTGGATTATTATCCTTATCCTTATCCTAATC
TTCCTAGCCCTTCAGGCTAGAGTAGGCTTCGATCCTGAGAACCTTGCTGTTGCTCTGAGG
AGATATAATTCTGGGAGAAAGAATCTTTTATAAGAACAGTACAGATTGTTCTCAAGAGGG
CCATCAGAAGGAAGCCAAAGAGTTCACAGCCTCAGCACCAACAACTCAACATGGTCATCA
TGTTTTCTATATGGTTTTTCCAGCTAGCAGTACTCCCTTCCATACCTGTGACTGGGCAGT
GCTTTTCTCTCTCCCATGTCTAGCCTCCAAAAGTTAAGTGAAAATTAGTCAACTGCACGT
GGAAGCCCCCACCACTTTGGGGATCTCTTTATTTCTTTTCAGCCAGGGACCTGTCCACTC
CCTTTGAATTAATATGGGAAGAAATTAATACAGGATGAACTGGAGAGAAGGGTTGAGTGT
GGCATACTTTCTGAAACCTGGAGCTGGGAATTGCGGAGAAGGGAAGGTCTAGACTAGTTA
CATCACATAGGGATTACTGTAAATCAAGTCATCTCAAGTCTAGTGAAGACAGCCAACAGA
AACAAAACCTAGCATAGGGATAGAAAATACCATGCACGTGTGCAGCCCCACCTAATTCCT
GCATCCAAGGCAGGTGTTGTTAATCTATCATAGCACCAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_002581
ORF Size 4884 bp
Insert Size 6800
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation The ORF of this clone has been fully sequenced and found to contain 2 SNPs compared with NM_002581.3.
Reference Data
RefSeq NM_002581.3, NP_002572.2
RefSeq Size 11025
RefSeq ORF 4884
Locus ID 5069
Protein Families Druggable Genome, Protease, Secreted Protein
Gene Summary This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

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