PAPP A (PAPPA) (NM_002581) Human Untagged Clone

CAT#: SC309898

PAPPA (untagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PAPPA
• Synonyms: ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002581 edited
  AACCGTCGGACATGCGGCTCTGGAGTTGGGTGCTGCACCTGGGGCTGCTGAGCGCCGCGC
  TGGGCTGCGGGCTGGCCGAGCGTCCCCGCCGGGCCCGGAGAGACCCGCGGGCCGGCCGAC
  CCCCGCGCCCCGCCGCCGGCCCGGCCACCTGCGCCACCCGGGCGGCCCGCGGCCGCCGCG
  CCTCGCCGCCGCCGCCGCCGCCGCCGGGCGGTGCCTGGGAAGCCGTGCGCGTCCCCCGGC
  GGCGGCAGCAGCGGGAGGCGAGGGGCGCCACCGAGGAGCCGAGCCCGCCGAGCCGGGCGC
  TCTATTTCAGCGGGCGAGGCGAGCAGCTGCGCCTCCGGGCCGACCTCGAGCTGCCCCGGG
  ACGCGTTCACGCTGCAAGTGTGGCTGCGAGCGGAGGGGGGCCAGAGGTCTCCGGCAGTGA
  TCACAGGGCTGTATGACAAATGTTCTTATATCTCACGTGACCGAGGATGGGTCGTGGGCA
  TTCACACCATCAGTGACCAAGACAACAAAGACCCACGCTACTTTTTCTCCTTGAAGACAG
  ACCGAGCCCGGCAAGTGACCACCATCAATGCCCACCGCAGCTACCTCCCAGGCCAGTGGG
  TATACCTAGCTGCCACCTATGATGGGCAGTTCATGAAGCTCTATGTGAATGGTGCCCAGG
  TGGCCACCTCTGGGGAACAAGTGGGTGGCATATTCAGCCCACTGACCCAGAAGTGCAAAG
  TGCTCATGTTAGGGGGCAGTGCCCTGAATCACAACTACCGGGGCTACATCGAGCACTTCA
  GTCTGTGGAAGGTGGCCAGGACTCAGCGGGAGATACTGTCTGACATGGAAACCCATGGCG
  CCCACACTGCTCTACCTCAGCTCCTCCTCCAGGAGAACTGGGACAATGTGAAGCATGCCT
  GGTCCCCCATGAAGGATGGCAGCAGCCCCAAAGTGGAATTCAGCAATGCCCACGGCTTTC
  TGCTGGACACGAGTCTGGAGCCTCCTCTGTGTGGACAGACATTGTGTGACAACACAGAGG
  TCATTGCCAGCTACAATCAGCTCTCAAGTTTCCGCCAGCCCAAGGTGGTGCGCTACCGCG
  TGGTCAACCTCTATGAAGATGATCATAAGAACCCGACGGTGACGCGCGAGCAGGTGGACT
  TCCAGCACCATCAGCTGGCTGAGGCCTTCAAGCAATACAACATCTCCTGGGAGCTGGACG
  TGCTGGAGGTGAGCAACTCCTCTCTTCGCCGCCGCCTCATCCTGGCCAACTGTGACATCA
  GCAAGATTGGGGATGAGAACTGTGACCCCGAGTGCAACCACACGCTGACGGGCCACGACG
  GCGGGGATTGCCGCCACCTGCGCCACCCTGCCTTCGTGAAGAAGCAGCACAACGGGGTGT
  GTGACATGGACTGCAACTATGAACGGTTCAACTTTGATGGTGGAGAGTGCTGTGACCCTG
  AAATCACCAATGTCACTCAGACTTGCTTTGACCCCGACTCTCCACACAGAGCCTACTTGG
  ATGTTAATGAGCTGAAGAACATTCTTAAATTGGATGGATCAACACATCTCAATATTTTCT
  TTGCAAAATCCTCAGAGGAGGAGTTGGCAGGAGTAGCAACTTGGCCATGGGACAAGGAGG
  CCCTGATGCACTTAGGTGGCATTGTCTTGAACCCATCTTTCTATGGCATGCCTGGGCACA
  CCCACACCATGATCCATGAGATTGGTCACAGCCTGGGCCTCTATCACGTCTTCCGAGGCA
  TCTCAGAAATCCAGTCCTGCAGTGACCCCTGCATGGAGACAGAGCCCTCCTTCGAGACTG
  GAGACCTCTGCAATGATACCAACCCAGCCCCTAAACACAAGTCCTGTGGTGACCCAGGGC
  CAGGAAATGACACCTGTGGCTTTCATAGCTTCTTCAACACTCCTTACAACAACTTCATGA
  GCTATGCAGATGACGACTGTACGGACTCCTTCACGCCCAATCAAGTCGCCAGAATGCACT
  GTTACCTGGACCTGGTCTACCAGGGCTGGCAGCCCTCCAGGAAACCAGCGCCTGTTGCCC
  TCGCCCCCCAAGTTCTGGGCCACACAACGGACTCTGTGACACTGGAGTGGTTCCCACCTA
  TAGATGGCCATTTCTTTGAAAGAGAATTGGGATCAGCATGTCATCTTTGCCTGGAAGGGA
  GAATCCTGGTGCAGTATGCTTCCAACGCTTCCTCCCCAATGCCCTGCAGCCCATCAGGAC
  ACTGGAGCCCTCGTGAAGCAGAAGGTCATCCTGATGTTGAACAGCCCTGTAAGTCCAGTG
  TCCGCACCTGGAGCCCAAATTCAGCTGTCAACCCACACACGGTTCCTCCAGCCTGCCCTG
  AGCCTCAAGGCTGCTACCTCGAGCTGGAGTTCCTCTACCCCTTGGTCCCTGAGTCTCTGA
  CCATTTGGGTGACCTTTGTCTCCACTGACTGGGACTCTAGTGGAGCTGTCAATGACATCA
  AACTGTTGGCTGTCAGTGGGAAGAACATCTCCCTGGGTCCTCAGAATGTCTTCTGTGATG
  TCCCACTGACCATCAGACTCTGGGACGTGGGCGAGGAGGTGTATGGCATCCAAATCTACA
  CGCTGGATGAGCACCTGGAGATCGATGCTGCCATGTTGACCTCCACTGCAGACACCCCAC
  TCTGTCTACAGTGTAAGCCCCTGAAGTATAAGGTGGTCCGGGACCCTCCTCTCCAGATGG
  ATGTGGCCTCCATCCTACATCTCAATAGGAAATTCGTAGACATGGATCTAAATCTTGGCA
  GTGTGTACCAGTATTGGGTCATAACTATTTCAGGAACTGAAGAGAGTGAGCCATCACCTG
  CTGTCACATACATCCATGGAAGTGGGTACTGTGGCGATGGCATTATACAAAAAGACCAAG
  GTGAACAATGCGACGACATGAATAAGATCAATGGTGATGGCTGCTCCCTTTTCTGCCGAC
  AAGAAGTCTCCTTCAATTGTATTGATGAACCCAGCCGGTGCTATTTCCATGATGGTGATG
  GGGTATGTGAGGAGTTTGAACAAAAAACCAGCATTAAGGACTGTGGTGTCTACACGCCCC
  AGGGATTCCTGGATCAGTGGGCATCCAATGCTTCAGTATCTCATCAAGACCAGCAATGCC
  CAGGCTGGGTCATCATCGGACAGCCAGCAGCATCCCAGGTGTGTCGAACCAAGGTGATAG
  ATCTCAGTGAAGGCATTTCCCAGCATGCCTGGTACCCTTGCACCATCAGCTACCCATATT
  CCCAGCTGGCTCAGACCACTTTTTGGCTCCGGGCGTATTTTTCTCAACCAATGGTTGCCG
  CAGCTGTCATTGTCCACCTGGTGACGGATGGGACATATTATGGGGACCAAAAGCAGGAGA
  CCATCAGCGTGCAGCTGCTTGATACCAAAGATCAGAGCCACGATCTAGGCCTCCATGTCC
  TGAGCTGCAGGAACAATCCCCTGATTATCCCTGTGGTCCATGACCTCAGCCAGCCCTTCT
  ACCACAGCCAGGCGGTACGTGTGAGCTTCAGTTCGCCCCTGGTCGCCATCTCGGGGGTGG
  CCCTCCGTTCCTTCGACAACTTTGACCCCGTCACCCTGAGCAGCTGCCAGAGAGGGGAGA
  CCTACAGCCCTGCCGAGCAGAGCTGCGTGCACTTCGCATGTGAGAAAACTGACTGTCCAG
  AGCTGGCTGTGGAGAATGCTTATCTCAATTGCTCCAGCAGCGACCGCTACCACGGTGCCC
  AGTGTACTGTGAGCTGCCGGACAGGCTACGTGCTCCAGATACGGCGGGATGATGAGCTGA
  TCAAGAGCCAGACGGGACCCAGCGTCACAGTGACCTGTACAGAGGGCAAGTGGAATAAGC
  AGGTGGCCTGTGAGCCAGTCGACTGCAGCATCCCAGATCACCATCAAGTCTATGCTGCCT
  CCTTCTCCTGCCCTGAGGGCACCACCTTTGGCAGTCAATGTTCCTTCCAGTGCCGTCACC
  CTGCACAATTGAAAGGCAACAACAGCCTCCTGACCTGCATGGAGGATGGGCTGTGGTCCT
  TCCCAGAGGCCCTGTGTGAGCTCATGTGCCTCGCTCCACCCCCTGTGCCCAATGCAGACC
  TCCAGACCGCCCGGTGCCGAGAGAATAAGCACAAGGTGGGCTCCTTCTGCAAATACAAAT
  GCAAGCCTGGATACCATGTGCCTGGATCCTCTCGGAAGTCAAAGAAACGGGCCTTCAAGA
  CTCAGTGTACCCAGGATGGCAGCTGGCAGGAGGGAGCTTGTGTTCCTGTGACCTGTGACC
  CACCTCCACCAAAATTCCATGGGCTCTACCAGTGTACTAATGGCTTCCAGTTCAACAGTG
  AGTGTAGGATCAAGTGTGAAGACAGTGATGCCTCCCAGGGACTTGGGAGCAATGTCATTC
  ATTGCCGGAAAGATGGCACCTGGAACGGCTCCTTCCATGTCTGCCAGGAGATGCAAGGCC
  AGTGCTCGGTTCCAAACGAGCTCAACAGCAACCTCAAACTGCAGTGCCCTGATGGCTATG
  CCATAGGGTCGGAGTGTGCCACCTCGTGCCTGGACCACAACAGCGAGTCCATCATCCTGC
  CAATGAACGTGACCGTGCGTGACATCCCCCACTGGCTGAACCCCACACGGGTAGAGAGAG
  TTGTCTGCACTGCTGGTCTCAAGTGGTATCCTCACCCTGCTCTGATTCACTGTGTCAAAG
  GCTGTGAGCCCTTCATGGGAGACAATTATTGTGATGCCATCAACAACCGAGCCTTTTGCA
  ACTATGACGGTGGGGATTGCTGCACCTCCACAGTGAAGACCAAAAAGGTCACCCCATTCC
  CTATGTCCTGTGACCTACAAGGTGACTGTGCTTGTCGGGACCCCCAGGCCCAAGAACACA
  GCCGGAAAGACCTCCAGGGATACAGCCATGGCTAAGGAAGGACAAGAAGTTGTCAAAGAA
  TTCCCAACGCCAGGACCCACATCCCTTTGGTATTGATTTCACAGTCAGCTGCTCAACGGA
  ATGGCCTCTCCACACCAGGGATCCTTAGCACCCAACCGGTCTGCCCTTAATTTTACCCAG
  GAAGGACTCACATTGGGGCGAATGAACCAAGTTTCGCCATGCTGGATGATGAAATGGATT
  CCCATCCCAAAGTCTGAGATGGATTGCATATACAGTGTGCAGTCCCAGAGCCTCCTAAAA
  TTCTAGCCATTTGTCACACAACCACAGCAAGAAACGTGTTCTATATCTAGAGTGTGCCCA
  TCTGTGTTTAGTACACATGCATGCATACACACCCATACAAACATCTGTGTGAGGGCAGTT
  CTGGAGATGAGCAGAGAGAGACCGGAATAAACTCAATCTTTTCTTTCCCAAGCTCCTAGC
  CAACACTATCCTTGGGAGAAAGGAATTTGCAGAAACTGCTAAGACCAAGTGTGGAGATGT
  CAAGCTAGTTCACACTCTGAGGCTCAGAATATGTAGGACATGCACAATTGTGCAGTCCTT
  TGGGATTGGAAGTGAAACAGTCTGTGATCCCCTACCTTCTAGGGAACTAGGACCTAGGAA
  GAGGTAAAGATTATCAGGTATGCAAAGCGCCCCAATTCTTCTGCTGCCATGGGGGATTTT
  ACCCCAACTCCAGGGTTCGAGGCCAATCTGAGAATGGCTTAGGATTGCAATGTCAAGGTA
  TTATATCAGCCCCTTGCTTGAGGCTTGAGGTCATAATATCCCTCTAGGACTTACCTGTTC
  CCCCAGATCTTGCCTTGGGACCACATTTGCTGCTACTTTTCCTGCTGCTCTATCCTATAC
  ATTGAATAATCCAAGATGGTAGAACTAGGTTAGGAAAAATTCCACACAACCAAACAGTCT
  GCCTTAAAAGTGACCCACATTTTTCCATAGCTCCTCACTTTTTAGCCCTTCTGCAAGAGA
  AAAACCCTCATGGGTCCACATGGTGAGAAGTTAAGTTTCCTGTAAGTGGGCCTCTCACCC
  TGGAAAGGAGTTGAGGGACATCAGATGCTGGAACCCTCACTGAAAGTCCAGAATGTCTAA
  GCCAGTGTTAGATTTTGTAAACAAGTGGAACAGTGTTAAATTTCTATGATGTTGGAGCCA
  TCCAGAGACTACTGGAATTGTCGAGACTTTTGGATTATTATCCTTATCCTTATCCTAATC
  TTCCTAGCCCTTCAGGCTAGAGTAGGCTTCGATCCTGAGAACCTTGCTGTTGCTCTGAGG
  AGATATAATTCTGGGAGAAAGAATCTTTTATAAGAACAGTACAGATTGTTCTCAAGAGGG
  CCATCAGAAGGAAGCCAAAGAGTTCACAGCCTCAGCACCAACAACTCAACATGGTCATCA
  TGTTTTCTATATGGTTTTTCCAGCTAGCAGTACTCCCTTCCATACCTGTGACTGGGCAGT
  GCTTTTCTCTCTCCCATGTCTAGCCTCCAAAAGTTAAGTGAAAATTAGTCAACTGCACGT
  GGAAGCCCCCACCACTTTGGGGATCTCTTTATTTCTTTTCAGCCAGGGACCTGTCCACTC
  CCTTTGAATTAATATGGGAAGAAATTAATACAGGATGAACTGGAGAGAAGGGTTGAGTGT
  GGCATACTTTCTGAAACCTGGAGCTGGGAATTGCGGAGAAGGGAAGGTCTAGACTAGTTA
  CATCACATAGGGATTACTGTAAATCAAGTCATCTCAAGTCTAGTGAAGACAGCCAACAGA
  AACAAAACCTAGCATAGGGATAGAAAATACCATGCACGTGTGCAGCCCCACCTAATTCCT
  GCATCCAAGGCAGGTGTTGTTAATCTATCATAGCACCAAAAAAAAAAAAAAAA
  
• Restriction Sites: Please inquire
• ACCN: NM_002581
• ORF Size: 4884 bp
• Insert Size: 6800
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: The ORF of this clone has been fully sequenced and found to contain 2 SNPs compared with NM_002581.3.

Reference Data

• RefSeq: NM_002581.3, NP_002572.2
• RefSeq Size: 11025
• RefSeq ORF: 4884
• Locus ID: 5069
• Protein Families: Druggable Genome, Protease, Secreted Protein
• Gene Summary: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]