Synphilin 1 (SNCAIP) (NM_005460) Human Untagged Clone

CAT#: SC310047

SNCAIP (untagged)-Human synuclein, alpha interacting protein (SNCAIP)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SNCAIP
• Synonyms: Sph1; SYPH1
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005460, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGAAGCCCCTGAATACCTTGATTTGGATGAAATTGACTTTAGTGATGACATATCTTATTCAGTCACAT
  CACTCAAGACGATCCCAGAACTGTGCCGAAGATGTGATACGCAAAACGAAGACAGATCAGTTTCTAGCTC
  TAGCTGGAATTGTGGCATCTCAACTCTTATTACAAACACGCAAAAGCCCACAGGAATCGCTGATGTGTAC
  AGTAAGTTCCGCCCAGTGAAGCGGGTTTCGCCACTGAAACATCAGCCAGAGACTCTGGAGAACAATGAAA
  GTGATGACCAAAAGAACCAGAAAGTGGTTGAGTACCAGAAAGGGGGTGAGTCTGACCTGGGCCCCCAGCC
  TCAGGAGCTTGGCCCTGGAGATGGAGTGGGCGGCCCACCAGGTAAGAGCTCTGAGCCCAGCACATCGCTG
  GGTGAACTGGAGCACTACGACCTCGACATGGATGAGATTCTGGATGTGCCTTATATTAAATCCAGTCAGC
  AGCTTGCCTCTTTTACCAAGGTGACTTCAGAAAAAAGAATTTTGGGCTTATGCACAACCATCAATGGCCT
  TTCTGGCAAAGCCTGCTCTACAGGAAGTTCTGAGAGCTCATCATCCAACATGGCACCATTTTGTGTTCTT
  TCTCCCGTGAAAAGCCCTCACTTGAGAAAAGCATCAGCTGTCATCCACGACCAGCACAAGCTGTCCACTG
  AAGAAACCGAGATCTCACCTCCTCTGGTTAAATGTGGCTCTGCATATGAGCCTGAAAACCAGAGTAAAGA
  CTTCCTAAACAAGACATTTAGTGATCCTCATGGTCGAAAAGTTGAGAAGACAACACCAGACTGCCAGCTC
  AGGGCCTTCCACCTACAATCCTCAGCAGCAGAATCCAAACCAGAAGAGCAGGTCAGTGGCCTAAACCGGA
  CCAGCTCCCAAGGCCCAGAAGAAAGGAGTGAGTATCTGAAAAAAGTGAAAAGCATCTTGAACATTGTTAA
  AGAAGGACAGATCTCTCTCCTGCCACACCTAGCTGCAGACAATCTAGACAAAATTCACGACGAAAATGGA
  AACAATCTATTACATATTGCGGCGTCACAGGGACACGCAGAGTGTCTACAGCACCTCACTTCTTTGATGG
  GAGAAGACTGCCTCAATGAGCGCAACACTGAGAAGTTGACTCCAGCAGGCCTGGCCATTAAGAATGGTCA
  GTTGGAGTGCGTACGCTGGATGGTGAGCGAAACAGAAGCCATTGCAGAACTGAGTTGTTCTAAGGATTTT
  CCAAGCCTTATTCATTACGCAGGTTGCTATGGCCAGGAAAAGATTCTTCTGTGGCTTCTTCAGTTTATGC
  AAGAACAGGGCATCTCGTTGGATGAAGTAGACCAGGATGGCAACAGTGCCGTTCACGTAGCCTCACAGCA
  TGGCTACCTTGGATGCATACAGACCTTGGTTGAATATGGAGCAAATGTCACCATGCAGAACCACGCTGGG
  GAAAAGCCCTCCCAGAGCGCCGAGCGGCAGGGGCACACCCTGTGCTCCAGGTACCTGGTGGTGGTGGAGA
  CCTGCATGTCGCTGGCCTCTCAAGTGGTGAAGTTAACCAAGCAGCTAAAGGAACAAACAGTAGAACGTGT
  CACGCTGCAGAACCAACTCCAACAATTTCTAGAAGCCCAGAAATCAGAGGGCAAGTCACTCCCTTCTTCA
  CCCAGTTCACCATCCTCACCTGCCTCCAGAAAGTCCCAGTGGAAATCTCCAGATGCAGATGATGATTCTG
  TAGCCAAAAGCAAGCCAGGAGTCCAAGAGGGGATTCAGGTTCTTGGAAGCCTGTCAGCCTCCAGCCGGGC
  TAGACCCAAAGCAAAAGATGAAGATTCTGATAAAATCTTACGCCAGTTATTGGGAAAGGAAATCTCAGAA
  AATGTCTGCACCCAGGAAAAACTGTCCTTGGAATTCCAGGATGCTCAGGCTTCCTCTAGAAATTCTAAAA
  AGATCCCACTGGAGAAGAGGGAACTGAAGTTAGCCAGGCTGAGACAGCTGATGCAGAGGTCACTGAGTGA
  GTCTGACACAGACTCCAACAACTCTGAGGACCCCAAGACTACCCCAGTGAGGAAGGCTGACCGACCAAGG
  CCGCAGCCCATTGTAGAAAGCGTAGAGAGTATGGACAGCGCAGAAAGCCTGCACCTGATGATTAAGAAAC
  ACACCTTGGCATCAGGGGGACGCAGGTTTCCTTTCAGCATCAAGGCCTCCAAATCCCTGGATGGCCACAG
  CCCATCTCCCACCTCAGAGAGCAGCGAACCAGACTTAGAATCCCAGTATCCAGGCTCAGGGAGTATTCCT
  CCAAACCAGCCCTCTGGTGACCCTCAGCAGCCCAGCCCTGACAGTACTGCTGCCCAGAAAGTTGCCACAA
  GTCCCAAGAGTGCCCTCAAGTCTCCATCTTCCAAGCGTAGGACATCTCAGAACTTAAAACTGAGAGTTAC
  CTTTGAGGAGCCTGTGGTGCAGATGGAGCAGCCTAGCCTTGAACTGAATGGAGAAAAAGACAAAGATAAG
  GGCAGGACTCTCCAGCGGACCTCCACAAGTAACGAATCGGGGGATCAACTGAAAAGGCCTTTTGGAGCCT
  TTCGATCTATCATGGAGACACTAAGTGGCAACCAAAACAATAATAATAACTACCAGGCAGCCAACCAGCT
  GAAAACCTCTACATTGCCCTTGACCTCACTTGGGAGGAAGACAGATGCCAAGGGAAACCCTGCCAGCTCC
  GCTAGCAAAGGAAAGAATAAGGCAGCATAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_005460
• ORF Size: 2760 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_005460.2, NP_005451.2
• RefSeq Size: 3569
• RefSeq ORF: 2760
• Locus ID: 9627
• Domains: ANK
• Protein Pathways: Parkinson's disease
• Gene Summary: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
  Transcript Variant: This variant (1, also known as variant a) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.