CLACP (COL25A1) (NM_032518) Human Untagged Clone

CAT#: SC310201

COL25A1 (untagged)-Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: COL25A1
• Synonyms: AMY; CFEOM5; CLAC; CLAC-P; CLACP
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_032518, the custom clone sequence may differ by one or more nucleotides
  ATGCTGCTGAAGAAGCACGCAGGGAAAGGAGGGGGCCGGGAGCCCAGATCCGAGGACCCG
  ACCCCTGCCGAACAGCATTGTGCCCGGACCATGCCCCCGTGTGCCGTCCTGGCGGCCCTC
  CTGTCAGTGGTGGCCGTGGTGTCTTGCCTGTACCTGGGTGTGAAAACCAACGACCTCCAG
  GCGAGGATCGCCGCTCTCGAATCCGCCAAAGGGGCCCCTTCCATTCATCTGCTGCCTGAT
  ACCCTGGATCACCTCAAGACTATGGTGCAAGAGAAAGTGGAGCGACTTCTGGCTCAGAAA
  TCCTATGAACATATGGCTAAAATAAGAATCGCAAGAGAAGCACCTTCAGAATGTAACTGC
  CCAGCAGGCCCTCCAGGGAAACGAGGTAAGAGAGGCCGAAGAGGAGAATCTGGTCCTCCT
  GGACAGCCTGGTCCTCAGGGCCCTCCTGGTCCAAAAGGCGATAAGGGAGAACAAGGTGAT
  CAGGGACCTAGGATGGTGTTTCCTAAAATCAATCATGGGTTTCTCTCTGCTGATCAGCAG
  CTCATTAAACGCCGCCTGATTAAGGGTGACCAAGGACAGGCAGGGCCTCCAGGACCCCCT
  GGCCCTCCAGGCCCAAGAGGGCCACCTGGGGACACAGGGAAAGATGGCCCCCGTGGAATG
  CCAGGAGTACCCGGTGAACCAGGAAAGCCAGGAGAACAAGGCTTGATGGGTCCTCTAGGG
  CCTCCGGGACAAAAGGGTTCTATTGGAGCACCTGGAATTCCAGGGATGAATGGGCAAAAG
  GGTGAGCCCGGGTTGCCTGGAGCAGTAGGACAGAATGGAATACCAGGACCTAAGGGAGAA
  CCTGGAGAACAAGGTGAAAAGGGAGACGCTGGAGAGAACGGCCCCAAGGGTGACACAGGC
  GAAAAGGGTGACCCTGGATCATCTGCTGCAGGAATTAAGGGAGAACCTGGGGAATCTGGT
  CGTCCAGGGCAAAAGGGTGAACCAGGGCTTCCTGGGCTTCCTGGACTTCCGGGGATAAAG
  GGAGAACCAGGTTTCATTGGTCCTCAAGGAGAACCAGGCTTACCAGGTTTACCAGGAACA
  AAAGGTGAACGGGGGGAAGCAGGGCCTCCTGGAAGAGGTGAGCGAGGGGAACCTGGAGCC
  CCCGGACCAAAGGGGAAACAAGGTGAATCAGGAACTAGAGGCCCAAAGGGGTCAAAGGGG
  GATCGTGGAGAAAAAGGGGACTCTGGAGCTCAGGGACCAAGGGGTCCACCTGGTCAAAAA
  GGGGATCAAGGAGCCACTGAGATCATAGACTACAACGGCAACCTCCACGAAGCCTTACAG
  AGGATTACCACCTTAACTGTCACGGGTCCCCCTGGACCTCCTGGACCTCAAGGACTACAA
  GGGCCAAAGGGAGAGCAGGGATCTCCAGGAATCCCAGGAATGGATGGAGAGCAGGGACTC
  AAAGGCTCAAAGGGAGACATGGGGGACCCAGGTATGACAGGTGAAAAAGGAGGAATTGGA
  CTTCCTGGATTACCGGGAGCCAATGGAATGAAAGGAGAAAAAGGAGATTCTGGAATGCCG
  GGTCCACAGGGTCCTTCTATCATAGGCCCACCAGGCCCACCAGGTCCCCATGGCCCACCT
  GGCCCCATGGGACCTCATGGACTTCCTGGACCAAAGGGTACAGATGGTCCTATGGGACCC
  CATGGCCCTGCAGGTCCCAAAGGAGAAAGAGGTGAAAAAGGAGCTATGGGAGAGCCTGGA
  CCAAGAGGGCCCTATGGGCTGCCTGGGAAAGATGGAGAGCCTGGTCTTGATGGCTTCCCT
  GGTCCACGGGGTGAGAAGGGTGATCTAGGAGAAAAGGGAGAAAAGGTGACCTCTCCATCC
  CAGCATGTACCTTGTTTGATTCTTCTCCTGCTGTCTGCTTTGCTGTTCAGCTTGTGTGAT
  TCCATTTGA
  
• Restriction Sites: Please inquire
• ACCN: NM_032518
• ORF Size: 1929 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_032518.2, NP_115907.2
• RefSeq Size: 2681
• RefSeq ORF: 1929
• Locus ID: 84570
• Domains: Collagen
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  Transcript Variant: This variant (2) lacks three 3' exons but includes an alternate 3' exon, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.