SH2B2 (NM_020979) Human Untagged Clone

CAT#: SC314274

SH2B2 (untagged)-Human SH2B adaptor protein 2 (SH2B2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH2B2
• Synonyms: APS
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_020979 edited
  GAGGCGCTCTGCCGCCGGCCCCTCCTCACTTCTTCCTCCCTGGGGATGGATCCAAGCTAT
  TGTCCTGCCCATGGCTTCCCATCTCAGGACCCTCTCTGGCCGCTATCATCCCAGCAGTGG
  AGTTCAGCCCACTACTCTGAACCAGCCGCAGGTGGCTGCGATGGGACGGAAGCCATGAAT
  GGTGCCGGCCCTGGCCCCGCCGCAGCCGCCCCGGTCCCAGTCCCGGTCCCGGTCCCGGAC
  TGGCGGCAGTTCTGCGAGCTGCATGCGCAGGCGGCCGCCGTGGACTTTGCGCACAAGTTC
  TGCCGTTTCCTGCGGGACAACCCAGCTTACGACACGCCCGACGCCGGCGCCTCCTTCTCC
  CGCCACTTCGCCGCCAACTTCCTGGACGTCTTCGGCGAGGAGGTGCGCCGCGTGCTGGTG
  GCTGGGCCGACGACTCGGGGCGCGGCCGTGAGCGCAGAGGCCATGGAGCCGGAGCTCGCG
  GACACCTCTGCACTCAAGGCGGCGCCCTACGGCCACTCGCGGAGCTCGGAGGACGTGTCC
  ACGCACGCGGCCACCAAGG:CCCGCGTTCGCAAGGGCTTCTCGCTGCGCAACATGAGCCT
  GTGCGTGGTGGACGGCGTGCGCGACATGTGGCACCGGCGCGCCTCGCCCGAGCCCGACGC
  GGCAGCTGCCCCGCGCACCGCCGAGCCCCGCGACAAGTGGACGCGGCGCCTGAGGCTGTC
  GCGGACGCTGGCTGCCAAGGTGGAGCTGGTGGACATTCAACGCGAGGGGGCGCTGCGCTT
  CATGGTGGCCGACGACGCGGCCGCGGGCTCCGGGGGCTCGGCTCAGTGGCAGAAGTGCCG
  CCTGCTCCTGCGCAGGGCTGTGGCCGAGGAACGCTTCCGCCTGGAGTTCTTCGTGCCGCC
  CAAAGCCTCCAGGCCCAAGGTCAGCATCCCACTGTCAGCCATCATTGAGGTCCGCACCAC
  CATGCCCCTGGAAATGCCAGAGAAGGATAACACATTCGTCCTCAAGGTAGAGAATGGAGC
  CGAATACATCTTGGAGACCATCGACTCTCTGCAGAAGCACTCGTGGGTAGCTGACATCCA
  GGGCTGCGTGGACCCCGGTGACAGTGAGGAAGACACCGAGCTCTCCTGTACCCGAGGAGG
  CTGTCTGGCCAGCCGCGTGGCCTCCTGCAGCTGTGAGCTCCTGACTGATGTCGACCTGCC
  CCGCCCCCCAGAGACGACAGCCGTGGGTGCAGTGGTGACAGCCCCCCACAGCCGAGGTCG
  AGATGCCGTCAGAGAATCCCTGATCCACGTCCCGCTAGAGACCTTTCTGCAGACCCTGGA
  ATCCCCGGGCGGCAGCGGCAGTGACAGCAATAACACAGGGGAACAGGGTGCAGAGACGGA
  TCCCGAGGCTGAACCCGAGCTGGAGCTATCCGACTACCCATGGTTCCACGGGACACTGTC
  CCGGGTCAAGGCTGCTCAACTGGTTCTGGCAGGGGGGCCCCGGAACCACGGCCTCTTCGT
  GATCCGCCAAAGTGAGACTCGGCCTGGGGAGTACGTGCTGACCTTCAACTTCCAGGGCAA
  GGCCAAGCACCTGCGCCTGTCCCTGAACGGCCACGGCCAGTGTCACGTACAGCATCTGTG
  GTTCCAGTCTGTGCTTGACATGCTCCGCCACTTCCACACACACCCCATCCCACTGGAGTC
  AGGGGGCTCGGCCGACATCACCCTTCGCAGCTATGTGCGGGCCCAGGACCCCCCACCAGA
  GCCGGGCCCCACGCCCCCTGCCGCGCCCGCGTCCCCGGCCTGCTGGAGCGACTCGCCCGG
  CCAGCACTACTTCTCCAGCCTCGCCGCGGCCGCCTGCCCGCCTGCCTCGCCCTCCGACGC
  CGCCGGCGCCTCCTCGTCTTCCGCCTCGTCGTCCTCTGCCGCGTCGGGGCCCGCCCCCCC
  GCGCCCCGTCGAGGGCCAGCTCAGCGCGCGGAGCCGCAGCAACAGCGCCGAGCGCCTGCT
  GGAGGCCGTGGCCGCCACCGCCGCCGAGGAGCCCCCGGAGGCCGCGCCCGGCCGCGCGCG
  CGCCGTGGAGAACCAGTACTCCTTCTACTAGCCCGCGGCGCCGCCCGGGTGGGACACGCC
  AAGCTCTTCAGTGAAGACACGATGTTATTAAAAGCCTGTTTTAGGGACTGCAAAAAAAAA
  AAAAAAAAA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_020979 unedited
  GGTTCAAATTTTGTATACGAACTCACTATAGGGCGGCCGCGAATTCGCACGAGGAGGCGC
  TCTGCCGCCGGCCCCTCCTCACTTCTTCCTCCCTGGGGATGGATCCAAGCTATTGTCCTG
  CCCATGGCTTCCCATCTCAGGACCCTCTCTGGCCGCTATCATCCCAGCAGTGGAGTTCAG
  CCCACTACTCTGAACCAGCCGCAGGTGGCTGCGATGGGACGGAAGCCATGAATGGTGCCG
  GCCCTGGCCCCGCCGCAGCCGCCCCGGTCCCAGTCCCGGTCCCGGTCCCGGACTGGCGGC
  AGTTCTGCGAGCTGCATGCGCAGGCGGCCGCCGTGGACTTTGCGCACAAGTTCTGCCGTT
  TCCTGCGGGACAACCCAGCTTACGACACGCCCGACGCCGGCGCCTCCTTCTCCCGCCACT
  TCGCCGCCAACTTCCTGGACGTCTTCGGCGAGGAGGTGCGCCGCGTGCTGGTGGCTGGGC
  CGACGACTCGGGGCGCGGCCGTGAGCGCAGAGGCCATGGAGCCGGAGCTCGCGGACACCT
  CTGCACTCAAGGCGGCGCCCTACGGCCACTCGCGGAGCTCGGAGGACGTGTCCACGCACG
  CGGCCACCAAGGCCCGCGTTCGCAAGGGCTTCTCGCTGCGCAACATGAGCCTGTGCGTGG
  TGGACGGCGTGCGCGACATGTGGCACCGGCGCGCCTCGCCCGAGCCCGACGCGGCAGCTG
  CCCCGCGCACCGTCGAGCCCCGCGACAAGTGGACGCGGCGCCTGAGGCTGTCGCGGACGC
  TGGCTGCCAGGTGGAGCTGGTGGACATTCACGCGAGGGGCGCTGCGCTTCATGGTGGCCG
  ACGACGCGCCGCGGCTNCGGGGGCTCGGCTCAATGGCAGAAATGCCGCCTGCTCTGCGCA
  GGGCTGN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_020979 unedited
  GCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTGCAGTCCCTAAAACAGGCTTTTA
  ATAACATCGTGTCTTCACTGAAGAGCTTGGCGTGTCCCACCCGGGCGGCGCCGCGGGCTA
  GTAGAAGGAGTACTGGTTCTCCACGGCGCGCGCGCGGCCGGGCGCGGCCTCCGGGGGCTC
  CTCGGCGGCGGTGGCGGCCACGGCCTCCAGCAGGCGCTCGGCGCTGTTGCTGCGGCTCCG
  CGCGCTGAGCTGGCCCTCGACGGGGCGCGGGGGGGCGGGCCCCGACGCGGCAGAGGACGA
  CGAGGCGGAAGACGAGGAGGCGCCGGCGGCGTCNGAGGGCGAGGCANGCGGGCAGGCGGC
  CGCGGCGAGGCTGGAGAAGTANTGCTGGCCGGGCGAGTCGCTCCAACAGGCCGGGGACGC
  GGGCGCGGCAGGGGGCGTGGGGCCCGGCTCTGGTGGGGGGTCCTGGGCCCGCACATAGCT
  GCGAAGGGTGATGTCGGCCGAGCCCCCTGACTCCANTGGGATGGGGTGTGTGTGGAAATG
  GCGGACCATGTCAAGCACAGACTGGAACCACAGATGCTGTACGTGACACTGGCCGTGGCC
  GTTCAGGGACAGGCGCAGGTGCTTGGCCTTGCCCTGGAGTTGAAGGTCAACACGTACTCC
  CCCAGCCGAGTCTCACTTTGGGCGATCACGAAGAAGCCGGGGTTCCCGGGGCCCCCCTGC
  CAGAACCAGTTGAGCACCCTTGACCCCGGACATGGTCCCCTGGAACCATTGGTAATCCGG
  ATACTTCCAGCTTGGGGTTCACCCTTGGGAATCCCGTCTTTTGACCTTGTTCCCCTTGGG
  TAATGGCTGCAACTGCCCGNTCGCCCTCCGGGGATTCCAAGGCCCCCAAAAAAGGTTTTA
  CGGGTACCGGGATAAGGATCTCTTTCCCCCATCTTCCCCCGCTGGGGGGGCCTGTTCTCC
  GTCCCCCGCCCCCCCTTCGGGGCCCCGCCC
  
• Restriction Sites: Please inquire
• ACCN: NM_020979
• ORF Size: 1899 bp
• Insert Size: 2200
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to contain 3bp deletion.

Reference Data

• RefSeq: NM_020979.1, NP_066189.1
• RefSeq Size: 2110
• RefSeq ORF: 1899
• Locus ID: 10603
• Domains: SH2, PH
• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Neurotrophin signaling pathway
• Gene Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]