SH2B2 (NM_020979) Human Untagged Clone

CAT#: SC327968

SH2B2 (untagged)-Human SH2B adaptor protein 2 (SH2B2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: SH2B2
• Synonyms: APS
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_020979, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGATCCAAGCTATTGTCCTGCCCATGGCTTCCCATCTCAGGACCCTCTCTGGCCGCTATCATCCCAGC
  AGTGGAGTTCAGCCCACTACTCTGAACCAGCCGCAGGTGGCTGCGATGGGACGGAAGCCATGAATGGTGC
  CGGCCCTGGCCCCGCCGCAGCCGCCCCGGTCCCAGTCCCGGTCCCGGTCCCGGACTGGCGGCAGTTCTGC
  GAGCTGCATGCGCAGGCGGCCGCCGTGGACTTTGCGCACAAGTTCTGCCGTTTCCTGCGGGACAACCCAG
  CTTACGACACGCCCGACGCCGGCGCCTCCTTCTCCCGCCACTTCGCCGCCAACTTCCTGGACGTCTTCGG
  CGAGGAGGTGCGCCGCGTGCTGGTGGCTGGGCCGACGACTCGGGGCGCGGCCGTGAGCGCAGAGGCCATG
  GAGCCGGAGCTCGCGGACACCTCTGCACTCAAGGCGGCGCCCTACGGCCACTCGCGGAGCTCGGAGGACG
  TGTCCACGCACGCGGCCACCAAGGCCCGCGTTCGCAAGGGCTTCTCGCTGCGCAACATGAGCCTGTGCGT
  GGTGGACGGCGTGCGCGACATGTGGCACCGGCGCGCCTCGCCCGAGCCCGACGCGGCAGCTGCCCCGCGC
  ACCGCCGAGCCCCGCGACAAGTGGACGCGGCGCCTGAGGCTGTCGCGGACGCTGGCTGCCAAGGTGGAGC
  TGGTGGACATTCAACGCGAGGGGGCGCTGCGCTTCATGGTGGCCGACGACGCGGCCGCGGGCTCCGGGGG
  CTCGGCTCAGTGGCAGAAGTGCCGCCTGCTCCTGCGCAGGGCTGTGGCCGAGGAACGCTTCCGCCTGGAG
  TTCTTCGTGCCGCCCAAAGCCTCCAGGCCCAAGGTCAGCATCCCACTGTCAGCCATCATTGAGGTCCGCA
  CCACCATGCCCCTGGAAATGCCAGAGAAGGATAACACATTCGTCCTCAAGGTAGAGAATGGAGCCGAATA
  CATCTTGGAGACCATCGACTCTCTGCAGAAGCACTCGTGGGTAGCTGACATCCAGGGCTGCGTGGACCCC
  GGTGACAGTGAGGAAGACACCGAGCTCTCCTGTACCCGAGGAGGCTGTCTGGCCAGCCGCGTGGCCTCCT
  GCAGCTGTGAGCTCCTGACTGATGCAGTCGACCTGCCCCGCCCCCCAGAGACGACAGCCGTGGGTGCAGT
  GGTGACAGCCCCCCACAGCCGAGGTCGAGATGCCGTCAGAGAATCCCTGATCCACGTCCCGCTAGAGACC
  TTTCTGCAGACCCTGGAATCCCCGGGCGGCAGCGGCAGTGACAGCAATAACACAGGGGAACAGGGTGCAG
  AGACGGATCCCGAGGCTGAACCCGAGCTGGAGCTATCCGACTACCCATGGTTCCACGGGACACTGTCCCG
  GGTCAAGGCTGCTCAACTGGTTCTGGCAGGGGGGCCCCGGAACCACGGCCTCTTCGTGATCCGCCAAAGT
  GAGACTCGGCCTGGGGAGTACGTGCTGACCTTCAACTTCCAGGGCAAGGCCAAGCACCTGCGCCTGTCCC
  TGAACGGCCACGGCCAGTGTCACGTACAGCATCTGTGGTTCCAGTCTGTGCTTGACATGCTCCGCCACTT
  CCACACACACCCCATCCCACTGGAGTCAGGGGGCTCGGCCGACATCACCCTTCGCAGCTATGTGCGGGCC
  CAGGACCCCCCACCAGAGCCGGGCCCCACGCCCCCTGCCGCGCCCGCGTCCCCGGCCTGCTGGAGCGACT
  CGCCCGGCCAGCACTACTTCTCCAGCCTCGCCGCGGCCGCCTGCCCGCCTGCCTCGCCCTCCGACGCCGC
  CGGCGCCTCCTCGTCTTCCGCCTCGTCGTCCTCTGCCGCGTCGGGGCCCGCCCCCCCGCGCCCCGTCGAG
  GGCCAGCTCAGCGCGCGGAGCCGCAGCAACAGCGCCGAGCGCCTGCTGGAGGCCGTGGCCGCCACCGCCG
  CCGAGGAGCCCCCGGAGGCCGCGCCCGGCCGCGCGCGCGCCGTGGAGAACCAGTACTCCTTCTACTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_020979
• ORF Size: 2028 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_020979.4, NP_066189.3
• RefSeq Size: 2226
• RefSeq ORF: 2028
• Locus ID: 10603
• Domains: SH2, PH
• Protein Families: Druggable Genome
• Protein Pathways: Insulin signaling pathway, Neurotrophin signaling pathway
• Gene Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]