PDE11A (NM_001077197) Human Untagged Clone

CAT#: SC315611

PDE11A (untagged)-Human phosphodiesterase 11A (PDE11A), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PDE11A
• Synonyms: PPNAD2
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001077197, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGCTGAAGCAGGCAAGAAGACCTTTATTCAGAAATGTGCTCAGTGCCACACAGTGGAAAAAGGTGAAAA
  TCACAAGACTGGTCCAAATCTCTGGGGCCTCTTTGGCTGAAAAACAGGAAAAGCACCAGGATTTTCTTAT
  ACAGAGGCAAACAAAAACAAAGGATCGACGATTCAATGATGAAATCGACAAGCTAACTGGATACAAGACA
  AAATCATTATTGTGCATGCCTATCCGAAGCAGTGATGGTGAGATTATTGGTGTGGCCCAAGCGATAAATA
  AGATTCCTGAAGGAGCTCCATTTACTGAAGATGATGAAAAAGTTATGCAGATGTATCTTCCATTTTGTGG
  AATCGCCATATCTAACGCTCAGCTCTTTGCTGCCTCAAGGAAAGAATATGAAAGAAGCAGAGCTTTGCTA
  GAGGTGGTTAATGACCTCTTTGAAGAACAGACTGACCTGGAGAAAATTGTCAAGAAAATAATGCATCGGG
  CCCAAACTCTGCTGAAATGTGAACGCTGTTCTGTTTTACTCCTAGAGGACATCGAATCACCAGTGGTGAA
  ATTTACCAAATCCTTTGAATTGATGTCCCCAAAGTGCAGTGCTGATGCTGAGAACAGTTTCAAAGAAAGC
  ATGGAGAAATCATCATACTCCGACTGGCTAATAAATAACAGCATTGCTGAGCTGGTTGCTTCAACAGGCC
  TTCCAGTGAACATCAGTGATGCCTACCAGGATCCGCGCTTTGATGCAGAGGCAGACCAGATATCTGGTTT
  TCACATAAGATCTGTTCTTTGTGTCCCTATTTGGAATAGCAACCACCAAATAATTGGAGTGGCTCAAGTG
  TTAAACAGACTTGATGGGAAACCTTTTGATGATGCAGATCAACGACTTTTTGAGGCTTTTGTCATCTTTT
  GTGGACTTGGCATCAACAACACAATTATGTATGATCAAGTGAAGAAGTCCTGGGCCAAGCAGTCTGTGGC
  TCTTGATGTGCTATCATACCATGCAACATGTTCAAAAGCTGAAGTTGACAAGTTTAAGGCAGCCAACATC
  CCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTTTCTCTCGACGTTGATGCCATGA
  TCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACACT
  GTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTC
  AACGTGTGTCAGCTGATGTTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAA
  TTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTCGACCACAGGGGAACCAACAATGCCTTCCAAGC
  TAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCACCATTTCAACCAC
  GCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACC
  TTATGCAGCTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATT
  CTTTGAACTTGTCAGTAAAGGAGAATACGATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATG
  TTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATCTCCAGACAGGTGGCAGAACTTG
  TAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATTTT
  TGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTG
  TATCAGGCACTGGTGAAGGTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTA
  AGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCAACTGCCTCATCCTCCCCTGCCAGTGTTATGGT
  AGCCAAGGAAGACAGGAACTAA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001077197
• ORF Size: 2052 bp
• Insert Size: 0
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001077197.1, NP_001070665.1
• RefSeq Size: 8316
• RefSeq ORF: 2052
• Locus ID: 50940
• Protein Families: Druggable Genome
• Protein Pathways: Progesterone-mediated oocyte maturation, Purine metabolism
• Gene Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (3) contains a distinct 5' UTR and 5' coding region, compared to variant 4. The resulting isoform (3) contains a shorter and distinct N-terminus, compared to isoform 4.