Munc 13 4 (UNC13D) (NM_199242) Human Untagged Clone

CAT#: SC316030

UNC13D (untagged)-Human unc-13 homolog D (C. elegans) (UNC13D)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: UNC13D
• Synonyms: FHL3; HLH3; HPLH3; Munc13-4
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_199242, the custom clone sequence may differ by one or more nucleotides
  ATGGCGACACTCCTCTCCCATCCGCAGCAGCGCCCTCCCTTCTTGCGCCAGGCCATCAAG
  ATAAGGCGCCGCAGAGTCAGAGATCTACAGGATCCCCCGCCCCAAATGGCCCCGGAGATC
  CAGCCTCCATCCCACCACTTCTCCCCCGAGCAGCGGGCCCTGCTCTACGAGGACGCACTC
  TACACTGTCTTGCACCGCCTGGGTCATCCTGAGCCCAACCATGTGACGGAGGCCTCTGAG
  CTGCTGCGATACCTGCAGGAGGCCTTCCACGTGGAGCCCGAGGAGCACCAGCAGACACTG
  CAGCGGGTCAGGGAGCTTGAGAAGCCAATATTTTGTCTGAAGGCAACAGTGAAACAGGCC
  AAGGGCATTCTGGGCAAAGATGTCAGTGGGTTCAGCGACCCCTACTGCCTGCTGGGCATT
  GAGCAGGGGGTAGGTGTGCCAGGGGGCAGCCCCGGGTCCCGGCATCGGCAGAAGGCTGTG
  GTGAGGCACACCATCCCCGAGGAGGAGACCCACCGCACGCAGGTCATCACCCAGACACTC
  AACCCCGTCTGGGACGAGACCTTCATCCTGGAGTTTGAGGACATCACCAATGCGAGCTTT
  CATCTGGACATGTGGGACCTGGACACTGTGGAGTCTGTCCGACAGAAGCTTGGGGAGCTC
  ACGGATCTGCATGGGCTTCGCAGGATCTTTAAAGAGGCCCGGAAGGACAAAGGCCAGGAC
  GACTTTCTGGGGAACGTGGTTCTGAGGCTGCAGGACCTGCGCTGCCGAGAGGACCAGTGG
  TACCCCCTGGAACCCCGCACTGAGACCTACCCAGACCGAGGCCAGTGCCACCTCCAGTTC
  CAACTCATCCATAAGCGGAGAGCCACTTCGGCCAGCCGCTCGCAGCCGAGCTACACCGTG
  CACCTCCACCTCCTGCAGCAGCTTGTGTCCCACGAGGTCACCCAGCACGAGGCGGGAAGC
  ACCTCCTGGGACGGGTCGCTGAGTCCCCAGGCTGCCACCGTCCTCTTTCTGCACGCCACA
  CAGAAGGACCTATCCGACTTCCACCAGTCCATGGCGCAGTGGCTGGCCTACAGCCGCCTC
  TACCAGAGCCTGGAGTTCCCCAGCAGCTGCCTCCTGCACCCCATCACCAGCATCGAGTAC
  CAGTGGATCCAGGGTCGGCTCAAGGCAGAACAGCAGGAGGAGCTGGCCGCCTCATTCAGC
  TCCCTGCTGACCTACGGCCTCTCCCTCATCCGGAGGTTCCGCTCTGTCTTCCCCCTCTCT
  GTCTCGGACTCCCCAGCCCGGCTGCAGTCTCTTCTCAGGGTCCTGGTACAGATGTGCAAG
  ATGAAGGCCTTTGGAGAACTGTGCCCCAACACCGCCCCATTGCCCCAGCTGGTGACTGAG
  GCCCTGCAGACTGGCACCACTGAATGGTTCCACCTGAAGCAGCAGCACCATCAACCCATG
  GTGCAGGGCATCCCGGAGGCAGGCAAGGCCTTGCTGGGCCTGGTACAGGATGTCATTGGC
  GACCTGCACCAGTGCCAGCGCACATGGGACAAGATCTTCCACAATACCCTCAAGATCCAC
  CTCTTCTCCATGGCTTTCCGGGAGCTGCAGTGGCTGGTGGCCAAGCGGGTGCAGGACCAC
  ACGACGGTTGTGGGTGATGTAGTGTCCCCAGAGATGGGCGAGAGTCTGTTCCAGCTCTAC
  ATCAGCCTCAAGGAGCTCTGCCAGCTGCGCATGAGCTCCTCAGAGAGGGATGGAGTCCTG
  GCCCTGGATAATTTCCACCGCTGGTTCCAGCCGGCCATCCCCTCCTGGCTGCAGAAGACG
  TACAACGAGGCCCTGGCGCGGGTGCAGCGCGCTGTGCAGATGGATGAGCTGGTGCCCCTG
  GGTGAACTGACCAAGCACAGCACATCAGCGGTGGATCTATCCACCTGCTTTGCCCAGATC
  AGCCACACTGCCCGGCAGCTGGACTGGCCAGACCCAGAGGAGGCCTTCATGATTACCGTC
  AAGTTTGTGGAGGACACCTGTCGCCTGGCCCTGGTGTACTGCAGCCTTATAAAGGCCCGG
  GCCCGCGAGCTCTCTTCAGGCCAGAAGGACCAAGGCCAGGCAGCCAACATGCTGTGTGTG
  GTGGTGAATGACATGGAGCAGCTGCGGCTGGTGATCGGCAAGTTGCCCGCCCAGCTGGCA
  TGGGAGGCCCTGGAGCAGCGGGTAGGGGCCGTGCTGGAGCAGGGGCAGCTGCAGAACACG
  CTGCATGCCCAGCTGCAGAGCGCGCTGGCCGGGCTGGGCCATGAGATCCGCACTGGCGTC
  CGCACCCTGGCCGAGCAGTTGGAGGTGGGCATCGCCAAGCACATCCAGAAACTGGTGGGC
  GTCAGGGAGTCTGTCCTGCCTGAGGATGCCATTCTGCCCCTGATGAAGTTCCTGGAGGTG
  GAGCTTTGCTACATGAACACCAACTTGGTGCAGGAGAACTTCAGCAGCCTCCTGACCCTG
  CTCTGGACCCACACACTCACAGTGCTGGTGGAGGCGGCCGCCTCCCAGCGCAGCTCATCC
  CTGGCTTCCAACAGGCTGAAGATTGCCCTGCAGAACCTGGAGATCTGCTTCCACGCTGAG
  GGCTGTGGCCTGCCACCCAAGGCCCTGCACACTGCCACCTTCCAGGCTCTGCAGAGGGAC
  CTGGAGCTGCAGGCGGCCTCCAGCCGGGAACTCATCCGGAAGTACTTCTGCAGCCGAATC
  CAGCAGCAGGCAGAAACCACCTCTGAGGAGCTGGGGGCTGTGACAGTCAAGGCCTCCTAC
  CGCGCCTCTGAGCAGAAGCTGCGTGTGGAGCTGCTCAGCGCCTCCAGCCTGCTGCCCCTG
  GACTCCAATGGCTCCAGCGACCCCTTTGTCCAGCTGACCTTGGAGCCCAGGCATGAGTTC
  CCTGAGCTGGCCGCCCGGGAGACCCAGAAGCACAAGAAGGACCTTCACCCATTGTTTGAT
  GAGACCTTTGAATTCCTGGTGCCTGCTGAGCCGTGCCGCAAGGCTGGGGCATGCCTCCTG
  CTCACCGTGCTGGACTACGACACGCTGGGGGCCGACGACCTGGAAGGCGAGGCCTTCCTG
  CCGCTGCGTGAGGTGCCCGGGCTGAGTGGCTCTGAGGAGCCTGGTGAGGTGCCTCAGACC
  CGCCTGCCCCTCACGTACCCCGCACCCAACGGGGACCCAATCCTGCAGCTGCTGGAGGGC
  CGGAAGGGTGACCGAGAAGCCCAGGTCTTTGTGAGGCTGCGGCGGCACCGGGCCAAGCAG
  GCCTCCCAGCATGCCTTGCGGCCGGCACCG
  
• Restriction Sites: Please inquire
• ACCN: NM_199242
• ORF Size: 3273 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_199242.2, NP_954712.1
• RefSeq Size: 4406
• RefSeq ORF: 3273
• Locus ID: 201294
• Gene Summary: This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]