TMC6 (NM_007267) Human Untagged Clone

CAT#: SC318289

TMC6 (untagged)-Human transmembrane channel-like 6 (TMC6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMC6
• Synonyms: EV1; EVER1; EVIN1; LAK-4P
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_007267, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCC
  CCTATGATGAAAGCGAAGTGCACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCA
  GGAGGGGCTGGAGCTGCAGCAGAGAGAGCGGGAGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCC
  GAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCCGCACCATTGGCCGCAGCC
  GAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGCCGGCCCCTGCT
  CGGGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTGGAGCTGGACCCCACGGCCCTG
  GAGGAGGAGGAGAAGCAGAGCCTCCTGGTGAAGGAGCTCCAGAGCCTGGCAGTGGCACAGCGGGACCACA
  TGCTTCGCGGGATGCCCTTAAGCCTGGCTGAGAAACGCAGCCTGCGAGAGAAGAGCAGGACCCCGAGGGG
  GAAGTGGAGGGGCCAGCCGGGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATGCCTGCGTG
  CTGGCCTTGCACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCCC
  TGAAGCGCATCGGGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAGACCCTGCTGGC
  TTTCAATGCCCTCCTGCTGCTGCTGCTGGTGGCCTTCATCATGGGCCCTCAGGTCGCCTTCCCACCCGCC
  CTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTCCTCACAGGCGCGGGTTGCTTCACCCACACCG
  TCATGTACTACGGCCACTACAGTAACGCCACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCA
  GTGCACACCCAGGGTGGGTGGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGC
  TTCTTTATCACCTGCATCACCCTGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCA
  GCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTGACGCAGAAGCGGGCCTC
  CCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGAGCTGCTGGCCGAGTGGCAGCTGCGGCACAGC
  CCCAGGAGCGTGTGCGGGAGGCTGCGGCAGGCGGCTGTGCTGGGGCTTGTGTGGCTGCTGTGTCTGGGGA
  CCGCGCTGGGCTGCGCCGTGGCCGTCCACGTCTTCTCGGAGTTCATGATCCAGAGTCCAGAGGCTGCTGG
  CCAGGAGGCTGTGCTGCTGGTCCTGCCCCTGGTGGTTGGCCTCCTCAACCTGGGGGCCCCCTACCTGTGC
  CGTGTCCTGGCCGCCCTGGAGCCGCATGACTCCCCGGTACTGGAGGTGTACGTGGCCATCTGCAGGAACC
  TCATCCTCAAGCTGGCCATCCTGGGGACACTGTGCTACCACTGGCTGGGCCGCAGGGTGGGCGTCCTGCA
  GGGCCAGTGCTGGGAGGATTTTGTGGGCCAGGAGCTGTACCGGTTCCTGGTGATGGACTTCGTCCTCATG
  TTGCTGGACACGCTTTTTGGGGAACTGGTGTGGAGGATTATCTCCGAGAAGAAGCTGAAGAGGAGGCGGA
  AGCCGGAGTTTGACATTGCCCGGAATGTCCTGGAGCTGATTTATGGGCAGACTCTGACCTGGCTGGGGGT
  GCTCTTCTCGCCCCTCCTCCCCGCCGTGCAGATCATCAAGCTGCTGCTCGTCTTCTATGTCAAGAAGACC
  AGCCTTCTGGCCAACTGCCAGGCGCCGCGCCGGCCCTGGCTGGCCTCACACATGAGCACCGTCTTCCTCA
  CGCTGCTCTGCTTCCCCGCCTTCCTGGGCGCCGCTGTCTTCCTCTGCTACGCCGTCTGGCAGGTGAAGCC
  CTCGAGCACCTGCGGCCCCTTCCGGACCCTGGACACCATGTACGAGGCCGGCAGGGTGTGGGTGCGCCAC
  CTGGAGGCGGCAGGCCCCAGGGTCTCCTGGCTGCCCTGGGTGCACCGGTACCTGATGGAAAACACCTTCT
  TTGTCTTCCTGGTGTCAGCCCTGCTGCTGGCCGTGATCTACCTCAACATCCAGGTGGTGCGGGGCCAGCG
  CAAGGTCATCTGCCTGCTCAAGGAGCAGATCAGCAATGAGGGTGAGGACAAAATCTTCTTAATCAACAAG
  CTTCACTCCATCTACGAGAGGAAGGAGAGGGAGGAGAGGAGCAGGGTTGGGACAACCGAGGAGGCTGCGG
  CACCCCCTGCCCTGCTCACAGATGAACAGGATGCCTAG
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_007267
• ORF Size: 2418 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_007267.7, NP_009198.4
• RefSeq Size: 2835
• RefSeq ORF: 2418
• Locus ID: 11322
• Protein Families: Transmembrane
• Gene Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.