TMC6 (NM_007267) Human Untagged Clone

CAT#: SC320504

TMC6 (untagged)-Human transmembrane channel-like 6 (TMC6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TMC6
• Synonyms: EV1; EVER1; EVIN1; LAK-4P
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_007267.5 AGGAAGCGGAGGAAGGTGAAGTAGGACCGAATTCCTGTGCCGAAGAGGCCTGCAGTGGGA
  GAGCAGGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGTCTGCAGAC
  TAGCGGGCATTGGCCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAG
  ACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAAGCGAAGTGCACGACTCC
  TTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGGAGCTGCAG
  CAGAGAGAGCGGGAGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCGAGGGCACC
  CAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCCGCACCATTGGCCGCAGC
  CGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGC
  CGGCCCCTGCTCGGGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTG
  GAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCCTCCTGGTGAAGGAGTTC
  CAGAGCCTGGCAGTGGCACAGCGGGACCACATGCTTCGCGGGATGCCCTTAAGCCTGGCT
  GAGAAACGCAGCCTGCGAGAGAAGAGCAGGACCCCGAGGGGGAAGTGGAGGGGCCAGCCG
  GGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATGCCTGCGTGCTGGCCTTG
  CACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCC
  CTGAAGCGCATCGGGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAG
  ACCCTGCTGGCTTTCAATGCCCTCCTGCTGCTGCTGCTGGTGGCCTTCATCATGGGCCCT
  CAGGTCGCCTTCCCACCCGCCCTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTC
  CTCACAGGCGCGGGTTGCTTCACCCACACCGTCATGTACTACGGCCACTACAGTAACGCC
  ACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCAGTGCACACCCAGGGTGGGT
  GGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGCTTCTTTATC
  ACCTGCATCACCCTGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGC
  AGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTGACGCAG
  AAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGAGCTGCTGGCC
  GAGTGGCAGCTGCGGCACAGCCCCAGGAGCGTGTGCGGGAGGCTGCGGCAGGCGGCTGTG
  CTGGGGCTTGTGTGGCTGCTGTGTCTGGGGACCGCGCTGGGCTGCGCCGTGGCCGTCCAC
  GTCTTCTCGGAGTTCATGATCCAGAGTCCAGAGGCTGCTGGCCAGGAGGCTGTGCTGCTG
  GTCCTGCCCCTGGTGGTTGGCCTCCTCAACCTGGGGGCCCCCTACCTGTGCCGTGTCCTG
  GCCGCCCTGGAGCCGCATGACTCCCCGGTACTGGAGGTGTACGTGGCCATCTGCAGGAAC
  CTCATCCTCAAGCTGGCCATCCTGGGGACACTGTGCTACCACTGGCTGGGCCGCAGGGTG
  GGCGTCCTGCAGGGCCAGTGCTGGGAGGATTTTGTGGGCCAGGAGCTGTACCGGTTCCTG
  GTGATGGACTTCGTCCTCATGTTGCTGGACACGCTTTTTGGGGAACTGGTGTGGAGGATT
  ATCTCCGAGAAGAAGCTGAAGAGGAGGCGGAAGCCGGAGTTTGACATTGCCCGGAATGTC
  CTGGAGCTGATTTATGGGCAGACTCTGACCTGGCTGGGGGTGCTCTTCTCGCCCCTCCTC
  CCCGCCGTGCAGATCATCAAGCTGCTGCTCGTCTTCTATGTCAAGAAGACCAGCCTTCTG
  GCCAACTGCCAGGCGCCGCGCCGGCCCTGGCTGGCCTCACACATGAGCACCGTCTTCCTC
  ACGCTGCTCTGCTTCCCCGCCTTCCTGGGCGCCGCTGTCTTCCTCTGCTACGCCGTCTGG
  CAGGTGAAGCCCTCGAGCACCTGCGGCCCCTTCCGGACCCTGGACACCATGTACGAGGCC
  GGCAGGGTGTGGGTGCGCCACCTGGAGGCGGCAGGCCCCAGGGTCTCCTGGCTGCCCTGG
  GTGCACCGGTACCTGATGGAAAACACCTTCTTTGTCTTCCTGGTGTCAGCCCTGCTGCTG
  GCCGTGATCTACCTCAACATCCAGGTGGTGCGGGGCCAGCGCAAGGTCATCTGCCTGCTC
  AAGGAGCAGATCAGCAATGAGGGTGAGGACAAAATCTTCTTAATCAACAAGCTTCACTCC
  ATCTACGAGAGGAAGGAGAGGGAGGAGAGGAGCAGGGTTGGGACAACCGAGGAGGCTGCG
  GCACCCCCTGCCCTGCTCACAGATGAACAGGATGCCTAGGGGGACGGCGATGGGCCTCAC
  GGGCCCGCCCAGCACCCTGAGACCACACTGTTGCCTCCCAGTGACCCTGCTGGGACACCA
  GGACAAGGAAGACAGTTTCGCCTCTCGAAAGCCGCAGCTGCGCCTAGGCTGGAGCTGGAA
  GGGTGGGTGAATCCGGCTTGGGCATCCCCAATGAACTCTGCCCTGCCTGGGACTCTATTT
  ATTCTGATTAAAGGGGTTTTGCAAATGGGAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_007267.5 unedited
  GGAGACTGTGTAGTACGACTCCTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTAC
  CGAGGAGACTCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCGG
  ACCGACGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTG
  TAAAACGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCG
  GCACGAGGAGGAAGCGGAGGAAGGTGAAGTAGGACCGAATTCCTGTGCCGAAGAGGCCTG
  CAGTGGGAGAGCAGGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGT
  CTGCAGACTAGCGGGCATTGGCCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATG
  TCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAAGCGAAGTGC
  ACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGG
  AGCTGCAGCAGAGAGAGCGGGAGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCC
  GAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCCGCACCATT
  GGCCGCAGCCGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGC
  AGGAGCAGCCGGCCCCTGCTCGGGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTG
  TACGACCTGGAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCCTCTGTGAA
  AGAGTTCCAGAGCCTGGCAGTGCACAGCGGGACCACATGCTTTCGCGGGATGCCCTTAGC
  CTGCTGAAACGCAGCTGCAGAGAAGAGCAGACCCAGGGGGAATTGGAGGGCAAGCCGCAC
  GGCCGGGTCTGCTCTGCTGTGCCGCTCAAAATTGCCTGCCTG
• Restriction Sites: Please inquire
• ACCN: NM_007267
• ORF Size: 2418 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_007267.5, NP_009198.3
• RefSeq Size: 2815
• RefSeq ORF: 2418
• Locus ID: 11322
• Protein Families: Transmembrane
• Gene Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.