HSPC142 (BABAM1) (NM_014173) Human Untagged Clone

CAT#: SC319179

BABAM1 (untagged)-Human BRISC and BRCA1 A complex member 1 (BABAM1), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BABAM1
• Synonyms: C19orf62; HSPC142; MERIT40; NBA1
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_014173.2 CACGAGGGTACAACTTCCGGCTGTAAAGATGGCGGCTTCCTAGTGAGTCGGCGGCTGATT
  TAGAAGGAGGTTCAGGCTACGGTGAGCCGAAGCCACACAGGAGCCATGGAAGTGGCAGAG
  CCCAGCAGCCCCACTGAAGAGGAGGAGGAGGAAGAGGAGCACTCGGCAGAGCCTCGGCCC
  CGCACTCGCTCCAATCCTGAAGGGGCTGAGGACCGGGCAGTAGGGGCACAGGCCAGCGTG
  GGCAGCCGCAGCGAGGGTGAGGGTGAGGCCGCCAGTGCTGATGATGGGAGCCTCAACACT
  TCAGGAGCCGGCCCTAAGTCCTGGCAGGTGCCCCCGCCAGCCCCTGAGGTCCAAATTCGG
  ACACCAAGGGTCAACTGTCCAGAGAAAGTGATTATCTGCCTGGACCTGTCAGAGGAAATG
  TCACTGCCAAAGCTGGAGTCGTTCAACGGCTCCAAAACCAACGCCCTCAATGTCTCCCAG
  AAGATGATTGAGATGTTCGTGCGGACAAAACACAAGATCGACAAAAGCCACGAGTTTGCA
  CTGGTGGTGGTGAACGATGACACGGCCTGGCTGTCTGGCCTGACCTCCGACCCCCGCGAG
  CTCTGTAGCTGCCTCTATGATCTGGAGACGGCCTCCTGTTCCACCTTCAATCTGGAAGGA
  CTTTTCAGCCTCATCCAGCAGAAAACTGAGCTTCCGGTCACAGAGAACGTGCAGACGATT
  CCCCCGCCATATGTGGTCCGCACCATCCTTGTCTACAGCCGTCCACCTTGCCAGCCCCAG
  TTCTCCTTGACGGAGCCCATGAAGAAAATGTTCCAGTGCCCATATTTCTTCTTTGACGTT
  GTTTACATCCACAATGGCACTGAGGAGAAGGAGGAGGAGATGAGTTGGAAGGATATGTTT
  GCCTTCATGGGCAGCCTGGATACCAAGGGTACCAGCTACAAGTATGAGGTGGCACTGGCT
  GGGCCAGCCCTGGAGTTGCACAACTGCATGGCGAAACTGTTGGCCCACCCCCTGCAGCGG
  CCTTGCCAGAGCCATGCTTCCTACAGCCTGCTGGAGGAGGAGGATGAAGCCATTGAGGTT
  GAGGCCACTGTCTGAACCATCCCTGTACATCTGCACCTTCTTGTGCAAGGAAGTCCTTGG
  CCTAAAGCCTTGGTTCTCAAACTGGGTTCCTTGGGACCTCCGGGGTGGGGGGGTTCCAGG
  AGGCACGTAGGGTACCTTGCAGGGTCCTAGGAGGGAAACCCAGGATTCCAGGAGGGATCC
  CAGGAACTGTGGGCACCCATTTTCTGTGTCTCCCAGCCCATTTCCACTCCTAGTTTGTCA
  TGGATAATTTTTGTTCTTCCCTGTGTGATTTTTGCCATCAAAATAAAAATTTGAGACTCG
  TTAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_014173.2 unedited
  GACATTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGGTACAACTTCCG
  GCTGTAAAGATGGCGGCTTCCTAGTGAGTCGGCGGCTGATTTAGAAGGAGGTTCAGGCTA
  CGGTGAGCCGAAGCCACACAGGAGCCATGGAAGTGGCAGAGCCCAGCAGCCCCACTGAAG
  AGGAGGAGGAGGAAGAGGAGCACTCGGCAGAGCCTCGGCCCCGCACTCGCTCCAATCCTG
  AAGGGGCTGAGGACCGGGCAGTAGGGGCACAGGCCAGCGTGGGCAGCCGCAGCGAGGGTG
  AGGGTGAGGCCGCCAGTGCTGATGATGGGAGCCTCAACACTTCAGGAGCCGGCCCTAAGT
  CCTGGCAGGTGCCCCCGCCAGCCCCTGAGGTCCAAATTCGGACACCAAGGGTCAACTGTC
  CAGAGAAAGTGATTATCTGCCTGGACCTGTCAGAGGAAATGTCACTGCCAAAGCTGGAGT
  CGTTCAACGGCTCCAAAACCAACGCCCTCAATGTCTCCCAGAAGATGATTGAGATGTTCG
  TGCGGACAAAACACAAGATCGACAAAAGCCACGAGTTTGCACTGGTGGTGGTGAACGATG
  ACACGGCCTGGCTGTCTGGCCTGACCTCCGACCCCCGCGAGCTCTGTAGCTGCCTCTATG
  ATCTGGAGACGGCCTCCTGTTCCACCTTCAATCTGGAAGACTTTTCAGCCTCATCCAGCA
  GAAAACTGAGCTTCCCGGTCACAGAGAACGTGCAGACGATTCCCCCGCCATATGTGGTCC
  GCACCATCCCTTGTCTACAGCCCGTCCACCTTGCCAGCCCCAGTTCTCTTGACGAGCCCA
  TGAAGAAAATGTTCAGTGCCATATTTCTTCTTTGACGTTGTTTACTCACATGGCACTGGA
  GGAGAGGAGGAGGGAGATGGAGTTTGGAAGGATAATGTTGCTCG
• Restriction Sites: Please inquire
• ACCN: NM_014173
• ORF Size: 990 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_014173.2, NP_054892.2
• RefSeq Size: 1413
• RefSeq ORF: 990
• Locus ID: 29086
• Gene Summary: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).