MDS028 (ITFG2) (NM_018463) Human Untagged Clone

CAT#: SC319346

ITFG2 (untagged)-Human integrin alpha FG-GAP repeat containing 2 (ITFG2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ITFG2
• Synonyms: FGGAP1; MDS028
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_018463.2 CGCTCCCTCTGCTCTTGGAGGTGCCATGAGGTCAGTTAGCTACGTGCAGCGCGTGGCGCT
  GGAGTTCAGCGGGAGCCTCTTCCCGCACGCAATCTGCCTCGGAGACGTTGATAACGATAC
  GTTAAATGAACTGGTGGTGGGAGACACCAGCGGGAAGGTGTCTGTGTATAAAAATGATGA
  CAGTCGGCCATGGCTCACCTGTTCCTGCCAGGGAATGCTGACTTGCGTTGGGGTTGGAGA
  CGTGTGTAATAAAGGAAAGAACCTGTTGGTGGCAGTGAGTGCTGAAGGCTGGTTTCATTT
  GTTTGACCTGACACCTGCCAAGGTGTTGGATGCTTCTGGGCACCACGAGACACTAATCGG
  AGAGGAGCAGCGTCCAGTCTTCAAGCAGCACATCCCTGCCAACACCAAGGTCATGCTGAT
  CAGCGACATCGATGGAGATGGGTGTCGTGAGCTGGTGGTGGGCTACACAGACCGTGTGGT
  GCGAGCTTTCCGCTGGGAGGAGCTAGGTGAGGGTCCTGAACATCTGACAGGGCAGCTGGT
  GTCCCTCAAGAAATGGATGCTGGAGGGTCAGGTGGACAGCCTCTCAGTGACTCTGGGGCC
  ACTGGGTCTTCCTGAACTGATGGTGTCTCAGCCAGGTTGTGCGTATGCAATTCTACTGTG
  TACCTGGAAAAAGGACACTGGGTCCCCTCCTGCCTCTGAAGGGCCCACGGATGGTAGTAG
  GGAGACCCCAGCTGCCCGAGACGTGGTGCTGCACCAGACATCTGGCCGTATCCACAACAA
  GAATGTCTCCACTCACCTAATTGGCAACATCAAACAAGGCCACGGCACTGAGAGTAGTGG
  CTCTGGCCTCTTTGCCCTGTGCACCCTGGATGGGACACTGAAGCTCATGGAAGAAATGGA
  AGAAGCAGACAAGCTGCTGTGGTCAGTGCAGGTGGATCACCAGCTCTTTGCCCTGGAGAA
  ACTGGATGTCACCGGCAACGGGCATGAGGAGGTAGTTGCATGCGCCTGGGATGGACAGAC
  ATATATCATTGATCACAACCGCACCGTCGTCCGCTTCCAAGTGGATGAAAATATCCGTGC
  CTTCTGTGCAGGCCTGTACGCCTGCAAAGAGGGCCGCAACAGCCCCTGCCTCGTATATGT
  CACTTTCAACCAGAAGATCTATGTGTACTGGGAGGTGCAGCTGGAGCGGATGGAGTCTAC
  CAATCTGGTGAAACTGCTGGAGACCAAGCCGGAGTACCACAGCCTGCTGCAGGAGCTGGG
  CGTGGATCCTGACGACCTCCCTGTGACTCGTGCCCTGCTTCACCAAACGCTCTACCATCC
  AGACCAGCCACCACAGTGTGCTCCCTCAAGCCTCCAGGATCCCACCTAGCTGTACTTGCC
  TCATAGCTGGTGAAGGATTCTTCTGAACCCCCACCCTACCCCCTAAAGGTATCTGTGGTA
  TTGGCAGGATAGGGAATATGCATTACAGAAATGCAGGATTTGACTCTGGGCATGAAAGAT
  GGCAGCAGCCCTAGGGTGACCGTGAACTATAGACCTCGCAGTCTTTTCGGTGAAAGAAGA
  GACAAGTTGACCCTCTGCCCATTTCCTTATGGACCTCACCCATCATGCCAGCAGGGTCAT
  AGGACCCTGGCCTTGTTCCAAATCATCTGGGACATGACCCACTCCCCACTGTCACTGTGT
  TGAAAACAGAGACTTGTTTGTGTGGCCCCAACACCCATAAGGAAACCAGGCTTTAGGCCC
  AGGGGAGCAGTGGAGGTAAGGGCTCCACCCCATCTTAAGCTCTGTCTTCCGTGGCACAAT
  TCCAAGTTCTTGACGTTAGTAATTGTTAAAGGAATGGCAAACTGTAAAAAAAAAAAAAAA
  AAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018463.2 unedited
  GTGTCTATGTATACGACTCCTATAGGGCGGCCGGGAATTCGGCACGAGGCGCTCCCTCTG
  CTCTTGGAGGTGCCATGAGGTCAGTTAGCTACGTGCAGCGCGTGGCGCTGGAGTTCAGCG
  GGAGCCTCTTCCCGCACGCAATCTGCCTCGGAGACGTTGATAACGATACGTTAAATGAAC
  TGGTGGTGGGAGACACCAGCGGGAAGGTGTCTGTGTATAAAAATGATGACAGTCGGCCAT
  GGCTCACCTGTTCCTGCCAGGGAATGCTGACTTGCGTTGGGGTTGGAGACGTGTGTAATA
  AAGGAAAGAACCTGTTGGTGGCAGTGAGTGCTGAAGGCTGGTTTCATTTGTTTGACCTGA
  CACCTGCCAAGGTGTTGGATGCTTCTGGGCACCACGAGACACTAATCGGAGAGGAGCAGC
  GTCCAGTCTTCAAGCAGCACATCCCTGCCAACACCAAGGTCATGCTGATCAGCGACATCG
  ATGGAGATGGGTGTCGTGAGCTGGTGGTGGGCTACACAGACCGTGTGGTGCGAGCTTTCC
  GCTGGGAGGAGCTAGGTGAGGGTCCTGAACATCTGACAGGGCAGCTGGTGTCCCTCAAGA
  AATGGATGCTGGAGGGTCAGGTGGACAGCCTCTCAGTGACTCTGGGGCCACTGGGTCTTC
  CTGAACTGATGGTGTCTCAGCCAGGTTGTGCGTATGCAATTCTACTGTGTACCTGGAAAA
  AGGACACTGGGTCCCCTCCTGCCTCTGAAGGCCCACGGATGGTAGTAGGAGACCCCAGCT
  GCCCGAGACGTGGTGCTGCACCAGACATCTGGCCGTATCCACACAGATGTCTCCACCTCC
  CCTAATTGCAACATCAAACAAGCCACGGCACTGAAGTATGGCTCTTGGCCTCTTTGCCCT
  GTGCCACCCTGATGGAACACCTGAGCTCATGAGAATTGCAGAAGCAGAACAGCTTGCTTG
  T
• Restriction Sites: Please inquire
• ACCN: NM_018463
• ORF Size: 1344 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_018463.2, NP_060933.2
• RefSeq Size: 2155
• RefSeq ORF: 1344
• Locus ID: 55846
• Domains: FG-GAP
• Protein Families: Druggable Genome
• Gene Summary: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes a functional protein.