PATZ1 (NM_032051) Human Untagged Clone

CAT#: SC319573

PATZ1 (untagged)-Human POZ (BTB) and AT hook containing zinc finger 1 (PATZ1), transcript variant 4

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PATZ1
• Synonyms: dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_032051.1 CTATGTGGGGGGTGGTGCACCCCGCAGTCTAGACAGTCTGATCCGGGCTGGGGGCGTGTA
  CACTCGGCGCACCTGCGAGACTACAGAGCCTCGGGCCGGCACGTGTGGGGAGTGTGGACA
  CGTCTGCTGCGCCCCGCTTCTCGCTGCTGAGGGGAAGGGAGGGGGCGGGCAGGTGCAGCG
  GCCGGGCTAGTGGGAGGGGGCGGCGGCCATGGAGCGGGTGAACGACGCTTCGTGCGGCCC
  GTCTGGCTGCTACACATACCAGGTGAGCAGACACAGCACGGAGATGCTGCACAACCTGAA
  CCAGCAGCGCAAAAACGGCGGGCGCTTCTGCGACGTGCTCTTGCGGGTAGGCGACGAGAG
  CTTCCCAGCGCACCGCGCCGTGCTGGCCGCCTGCAGCGAGTACTTTGAGTCGGTGTTCAG
  CGCCCAGTTGGGCGACGGCGGAGCTGCGGACGGGGGTCCGGCTGATGTAGGGGGCGCGAC
  GGCAGCACCAGGCGGCGGGGCCGGGGGCAGCCGGGAGCTGGAGATGCACACTATCAGCTC
  CAAGGTATTTGGGGACATTCTGGACTTCGCCTACACTTCCCGCATCGTGGTGCGCTTGGA
  GAGCTTTCCCGAACTCATGACGGCCGCCAAGTTCCTGCTGATGAGGTCGGTTATCGAGAT
  CTGCCAGGAAGTCATCAAACAGTCCAACGTACAGATCCTGGTACCCCCTGCCCGCGCCGA
  TATAATGCTCTTTCGCCCCCCTGGGACCTCGGACTTGGGCTTCCCTTTGGACATGACCAA
  CGGGGCAGCCTTGGCAGCCAACAGCAATGGCATCGCCGGCAGCATGCAGCCAGAGGAGGA
  GGCAGCTCGGGCGGCTGGTGCAGCCATTGCAGGCCAAGCCTCTTTGCCTGTGTTACCTGG
  GGTGGACCGCTTGCCCATGGTGGCTGGACCCCTATCCCCCCAACTGCTGACTTCCCCATT
  CCCCAGTGTGGCATCCAGTGCCCCTCCCCTGACTGGCAAGCGAGGCCGGGGCCGCCCAAG
  GAAGGCCAACCTGCTGGACTCAATGTTTGGGTCCCCAGGGGGCCTGAGGGAGGCAGGCAT
  CCTTCCATGCGGTCTATGTGGTAAGGTGTTCACTGATGCCAACCGGCTCCGGCAGCACGA
  GGCCCAGCACGGTGTCACCAGCCTCCAGCTGGGCTACATCGACCTTCCTCCTCCGAGGCT
  GGGTGAGAATGGGCTACCCATCTCTGAAGACCCCGACGGCCCCCGAAAGAGGAGCCGGAC
  CAGGAAGCAGGTGGCTTGTGAGATCTGCGGCAAGATCTTCCGTGATGTGTATCATCTTAA
  CCGGCACAAGCTGTCCCACTCTGGGGAGAAGCCCTACTCCTGCCCTGTGTGTGGGTTGCG
  GTTCAAGAGAAAAGACCGCATGTCCTACCATGTGCGGTCCCATGATGGGTCCGTGGGCAA
  GCCTTACATCTGCCAGAGCTGTGGGAAAGGCTTCTCCAGGCCTGATCACTTGAACGGACA
  TATCAAGCAGGTGCACACTTCTGAGCGGCCTCACAAGTGTCAGGTGTGGGTTGGGAGCAG
  CAGCGGCCTGCCGCCCCTGGAACCTCTTCCTAGCGACCTGCCATCATGGGACTTTGCCCA
  GCCTGCTTTGTGGAGGTCGTCCCATTCGGTTCCTGACACCGCCTTTTCCCTTTCTCTAAA
  AAAATCATTCCCAGCCCTTGAAAACCTGGGCCCAGCACACTCCAGCAACACTCTCTTCTG
  CCCAGCCCCGCCGGGATATCTGAGGCAGGGCTGGACCACCCCAGAGGGCAGCAGGGCCTT
  TACCCAGTGGCCTGTTGGCTAGCCTGGGCCTCCCTGGAGAGGGTTGACAGTGGAAGGGAA
  CAGGAGGGGCATTTGGCCTGAGACCCCTGCTTTTGGGAGAGGCTAGCAGGGTGGTTCCTG
  CCCAGCATGCCCAGCTCCTCCCTGGGTGACTCGGAGTCTTTCCCATGTCAGAGCCCCCAA
  ATGGGGGTAGCAAGGAGCACCTTTCTGGAACCCCCTATAGCATCCAAGTTTCTTTCTGGG
  CTCTCTTGCCTTTTCCCCCCTTTCACAGATGGCACCCCTGGGCATCTGTCCTTGCCTAGG
  TGATTTTGGAGGTTGGTGCCTTCCTGGGAACTAGCCACCAGCTTATCTGCTTCCCTTCCC
  CTGGCATCACTTCCCATAGGCCTGGGGTTTCTAGACTGGGGCCTGGCCACCCCTTTCCCC
  ACTCCACGAGTGAGTCGGCCTCCAGAGAAGACTGGCACAATTCCAACTAGAGTCAACCCA
  TGCTGCCCTCTGCCCTTCCCACTCAGATCTAGATCCTGCTTTCATTTCTGGCTAGTGAAG
  TAGACTTTTGTGTTTTTGAGGTTTATTAGCAGGTCTGCTCAGGAACCAAACTAATGAGTA
  GCTTTATATTGGGCCACCCCAATATATGGCTTTGGGGGCTGAAAAAGCAGATGTAGACCC
  CCTCCCTCGGATCCTTATTGGTGTGCCCTTTAGCACTCCGCAGACTCTGCGGGGTGAACA
  GGAGTGATGATAAAATTTTTCATTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_032051.1 unedited
  GTCTTATTGTAGGTCACAGAGTATACGACTTCCTATAGGGCGGCCGGGAATTCGGCACGA
  GGCTATGTTGGGGGGTGGTGCACCCCGCAGTCTAGACAGTCTGATCCGGGCTGGGGGCGT
  GTACACTCGGCGCACCTGCGAGACTACAGAGCCTCGGGCCGGCACGTGTGGGGAGTGTGG
  ACACGTCTGCTGCGCCCCGCTTCTCGCTGCTGAGGGGAAGGGAGGGGGCGGGCAGGTGCA
  GCGGCCGGGCTAGTGGGAGGGGGCGGCGGCCATGGAGCGGGTGAACGACGCTTCGTGCGG
  CCCGTCTGGCTGCTACACATACCAGGTGAGCAGACACAGCACGGAGATGCTGCACAACCT
  GAACCAGCAGCGCAAAAACGGCGGGCGCTTCTGCGACGTGCTCTTGCGGGTAGGCGACGA
  GAGCTTCCCAGCGCACCGCGCCGTGCTGGCCGCCTGCAGCGAGTACTTTGAGTCGGTGTT
  CAGCGCCCAGTTGGGCGACGGCGGAGCTGCGGACGGGGGTCCGGCTGATGTAGGGGGCGC
  GACGGCAGCACCAGGCGGCGGGGCCGGGGGCAGCCGGGAGCTGGAGATGCACACTATCAG
  CTCCAAGGTATTTGGGGACATTCTGGACTTCGCCTACACTTCCCGCATCGTGGTGCGCTT
  GGAGAGCTTTCCCGAACTCATGACGGCCGCCAAGTTCCTGCTGATGAGGTCGGTTATCGA
  GATCTGCCAGGAAGTCATCAAAACAGTCCAACGTACAGATCCTGGTACCCCCTGCCCGCG
  CCGATATAATGCTCTTTCGCCCCCCCTGGGACCTCGGACTTGGGCTTCCCTTGGACATGA
  CCAACGGGGCAGCCCTTGGCAGCCAACAGCAATGGCATCGCCGCAGCATGCAGCCAGAGG
  AAGAGCAGCTCGGGCGCTGTGCAGCAATTGCAGGCAGGCCTCTTGCTGGTTACCTTGGGG
  TGGACCGCTTG
• Restriction Sites: Please inquire
• ACCN: NM_032051
• ORF Size: 1614 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_032051.1, NP_114440.1
• RefSeq Size: 3021
• RefSeq ORF: 1614
• Locus ID: 23598
• Domains: BTB, AT_hook, zf-C2H2
• Protein Families: Transcription Factors
• Gene Summary: The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences (compared to variant 1), one of which results in a frameshift. This results in a shorter protein (short isoform) with a distinct C-terminus, compared to the long C isoform. This short isoform interacts with RING finger protein 4 through its A-T hook DNA binding domain. It acts as a transcriptional repressor, whereas its partner RING finger protein 4 behaves as a transcriptional activator. Thus the association of this isoform with RING finger protein 4 seems to switch activation to repression.