EXOSC7 (NM_015004) Human Untagged Clone

CAT#: SC320874

EXOSC7 (untagged)-Human exosome component 7 (EXOSC7), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: EXOSC7
• Synonyms: EAP1; hRrp42p; p8; RRP42; Rrp42p
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_015004.2 GGCAGCATGGCGTCCGTGACGCTGAGCGAGGCGGAGAAGGTGTACATCGTGCATGGCGTC
  CAGGAAGACCTCCGTGTGGATGGCCGTGGCTGTGAGGACTACCGATGTGTCGAAGTGGAA
  ACTGATGTGGTGTCCAACACTAGTGGGTCCGCCAGGGTCAAGCTGGGTCACACAGACATC
  TTGGTGGGAGTGAAAGCAGAAATGGGGACGCCGAAGCTGGAGAAACCAAATGAAGGCTAC
  TTGGAGTTCTTTGTTGACTGTTCAGCCAGTGCTACCCCTGAATTTGAAGGTAGAGGAGGT
  GATGACCTTGGCACCGAGATCGCTAACACCCTCTATCGGATATTTAACAATAAAAGCAGT
  GTCGACTTAAAGACCCTCTGCATTAGTCCTCGGGAGCACTGCTGGGTTCTCTATGTGGAT
  GTGCTGCTTCTGGAATGTGGTGGAAATTTGTTTGATGCCATTTCCATTGCTGTAAAGGCT
  GCTCTCTTCAATACAAGGATACCAAGGGTTCGAGTTTTGGAGGATGAAGAGGGGTCGAAG
  GACATTGAATTGTCAGATGACCCTTATGACTGCATACGACTAAGTGTGGAGAATGTCCCC
  TGCATTGTCACTCTGTGCAAGATTGGCTATCGGCATGTGGTGGATGCTACTCTTCAGGAG
  GAGGCCTGCTCGCTGGCCAGCTTGCTGGTGTCGGTGACCAGCAAGGGAGTTGTGACGTGC
  ATGAGGAAAGTGGGGAAGGGCAGCCTGGACCCAGAGAGCATCTTCGAGATGATGGAGACT
  GGCAAGCGTGTGGGCAAGGTACTGCATGCCTCCTTGCAGAGTGTTCTGCACAAGGAAGAA
  AGCCTGGGGCCCAAGAGACAGAAAGTTGGATTCCTGGGATGATTTGCACATCAACTGCTC
  AACTGTGGATTGTTTTTTACTTTTCCTTTTAAACCGGTTCGTATATATTTTTCTTCGCTG
  TTACGAATTTACAGCAGCATTTGTACATGTAAAATTAAAGGCTATTTTCTGGTAAAAAAA
  AAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_015004.2 unedited
  GCGATTGTATACGACTCCTATAGGGCGGCGAGGGAATTCGGCACGAGGGGCAGCATGGCG
  TCCGTGACGCTGAGCGAGGCGGAGAAGGTGTACATCGTGCATGGCGTCCAGGAAGACCTC
  CGTGTGGATGGCCGTGGCTGTGAGGACTACCGATGTGTCGAAGTGGAAACTGATGTGGTG
  TCCAACACTAGTGGGTCCGCCAGGGTCAAGCTGGGTCACACAGACATCTTGGTGGGAGTG
  AAAGCAGAAATGGGGACGCCGAAGCTGGAGAAACCAAATGAAGGCTACTTGGAGTTCTTT
  GTTGACTGTTCAGCCAGTGCTACCTCTGTTTTTGAAGGTAGAGGAGGTGATGACCTTGGC
  ACCGAGATCGCTAACACCCTCTATCGGATATTTAACAATAAAAGCAGTGTCGACTTAAAG
  ACCCTCTGCATTAGTCCTCGGGAGCACTGCTGGGTTCTCTATGTGGATGTGCTGCTTCTG
  GAATGTGGTGGAAATTTGTTTGATGCCATTTCCATTGCTGTAAAGGCTGCTCTCTTCAAT
  ACAAGGATACCAAGGGTTCGAGTTTTGGAGGATGAAGAGGGGTCGAAGGACATTGAATTG
  TCAGATGACCCTTATGACTGCATACGACTAAGTGTGGAGAATGTCCCCTGCATTGTCACT
  CTGTGCAAGATTGGCTATCGGCATGTGGTGGATGCTACTCTTCAGAGAGGCCTGCTCGCT
  GGCCAGCTTGCTGGTGTCGGTGACCAGCAAGGAAGTTGTGACGTGCATGAGAAAGTGGGG
  AAAGGGCAGCCTGACCCAGAAAGCATCTTCCACATGATGGAAAACTGCAAGCGTGTGGCA
  GTACTGCATGCCTCCCTGCAAATGTTCTGCCAAGAAAAGCCTGGGCCCAAAGAAACAAAC
  GTGGAATTCCTGGGGAGGATTTGCACATCAACTGGT
• Restriction Sites: Please inquire
• ACCN: NM_015004
• ORF Size: 876 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_015004.2, NP_055819.1
• RefSeq Size: 1036
• RefSeq ORF: 876
• Locus ID: 23016
• Domains: RNase_PH_C
• Protein Families: Stem cell - Pluripotency
• Protein Pathways: RNA degradation
• Gene Summary: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. [UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the protein.