ADAM15 (NM_003815) Human Untagged Clone

CAT#: SC321268

ADAM15 (untagged)-Human ADAM metallopeptidase domain 15 (ADAM15), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ADAM15
• Synonyms: MDC15
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003815.3 CCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGTTCCGCACTTGCTGCCCTCGC
  CCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTGGGC
  GCGGGCAGCCCTCTGCCTTCCTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAGCAG
  GCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGATCTC
  CCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAGTTG
  GAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGAATAGGGAGTTGGTCCCAGGC
  CGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACACACT
  TTGGAGAACTGCTGCTACCAGGGAAGAGTGCGGGGATATGCAGGCTCCTGGGTGTCCATC
  TGCACCTGCTCTGGGCTCAGAGGCTTGGTGGTCCTGACCCCAGAGAGAAGCTATACCCTG
  GAGCAGGGGCCTGGGGACCTTCAGGGTCCTCCCATTATTTCGCGAATCCAAGATCTCCAC
  CTGCCAGGCCACACCTGTGCCCTGAGCTGGCGGGAATCTGTACACACTCAGACGCCACCA
  GAGCACCCCCTGGGACAGCGCCACATTCGCCGGAGGCGGGATGTGGTAACAGAGACCAAG
  ACTGTGGAGTTGGTGATTGTGGCTGATCACTCGGAGGCCCAGAAATACCGGGACTTCCAG
  CACCTGCTAAACCGCACACTGGAAGTGGCCCTCTTGCTGGACACATTCTTCCGGCCCCTG
  AATGTACGAGTGGCACTAGTGGGCCTGGAGGCCTGGACCCAGCGTGACCTGGTGGAGATC
  AGCCCAAACCCAGCTGTCACCCTCGAAAACTTCCTCCACTGGCGCAGGGCACATTTGCTG
  CCTCGATTGCCCCATGACAGTGCCCAGCTGGTGACTGGTACTTCATTCTCTGGGCCTACG
  GTGGGCATGGCCATTCAGAACTCCATCTGTTCTCCTGACTTCTCAGGAGGTGTGAACATG
  GACCACTCCACCAGCATCCTGGGAGTCGCCTCCTCCATAGCCCATGAGTTGGGCCACAGC
  CTGGGCCTGGACCATGATTTGCCTGGGAATAGCTGCCCCTGTCCAGGTCCAGCCCCAGCC
  AAGACCTGCATCATGGAGGCCTCCACAGACTTCCTACCAGGCCTGAACTTCAGCAACTGC
  AGCCGACGGGCCCTGGAGAAAGCCCTCCTGGATGGAATGGGCAGCTGCCTCTTCGAACGG
  CTGCCTAGCCTACCCCCTATGGCTGCTTTCTGCGGAAATATGTTTGTGGAGCCGGGCGAG
  CAGTGTGACTGTGGCTTCCTGGATGACTGCGTCGATCCCTGCTGTGATTCTTTGACCTGC
  CAGCTGAGGCCAGGTGCACAGTGTGCATCTGACGGACCCTGTTGTCAAAATTGCCAGCTG
  CGCCCGTCTGGCTGGCAGTGTCGTCCTACCAGAGGGGATTGTGACTTGCCTGAATTCTGC
  CCAGGAGACAGCTCCCAGTGTCCCCCTGATGTCAGCCTAGGGGATGGCGAGCCCTGCGCT
  GGCGGGCAAGCTGTGTGCATGCACGGGCGTTGTGCCTCCTATGCCCAGCAGTGCCAGTCA
  CTTTGGGGACCTGGAGCCCAGCCCGCTGCGCCACTTTGCCTCCAGACCGCTAATACTCGG
  GGAAATGCTTTTGGGAGCTGTGGGCGCAACCCCAGTGGCAGTTATGTGTCCTGCACCCCT
  AGAGATGCCATTTGTGGGCAGCTCCAGTGCCAGACAGGTAGGACCCAGCCTCTGCTGGGC
  TCCATCCGGGATCTACTCTGGGAGACAATAGATGTGAATGGGACTGAGCTGAACTGCAGC
  TGGGTGCACCTGGACCTGGGCAGTGATGTGGCCCAGCCCCTCCTGACTCTGCCTGGCACA
  GCCTGTGGCCCTGGCCTGGTGTGTATAGACCATCGATGCCAGCGTGTGGATCTCCTGGGG
  GCACAGGAATGTCGAAGCAAATGCCATGGACATGGGGTCTGTGACAGCAACAGGCACTGC
  TACTGTGAGGAGGGCTGGGCACCCCCTGACTGCACCACTCAGCTCAAAGCAACCAGCTCC
  CTGACCACAGGGCTGCTCCTCAGCCTCCTGGTCTTATTGGTCCTGGTGATGCTTGGTGCC
  AGCTACTGGTACCGTGCCCGCCTGCACCAGCGACTCTGCCAGCTCAAGGGACCCACCTGC
  CAGTACAGGGCAGCCCAATCTGGTCCCTCTGAACGGCCAGGACCTCCGCAGAGGGCCCTG
  CTGGCACGAGGCACTAAGTCTCAGGGGCCAGCCAAGCCCCCACCCCCAAGGAAGCCACTG
  CCTGCCGACCCCCAGGGCCGGTGCCCATCGGGTGACCTGCCCGGCCCAGGGGCTGGAATC
  CCGCCCCTAGTGGTACCCTCCAGACCAGCGCCACCGCCTCCGACAGTGTCCTCGCTCTAC
  CTCTGACCTCTCCGGAGGTTCCGCTGCCTCCAAGCCGGACTTAGGGCTTCAAGAGGCGGG
  CGTGCCCTCTGGAGTCCCCTACCATGACTGAAGGCGCCAGAGACTGGCGGTGTCTTAAGA
  CTCCGGGCACCGCCACGCGCTGTCAAGCAACACTCTGCGGACCTGCCGGCGTAGTTGCAG
  CGGGGGCTTGGGGAGGGGCTGGGGGTTGGACGGGATTGAGGAAGGTCCGCACAGCCTGTC
  TCTGCTCAGTTGCAATAAACGTGACATCTTGGAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003815.3 unedited
  CACCTTGTATACGACTCCTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAG
  GAGATCTGCCGCCGCGATCGCGGCGCGCCAGATCTCAAGCTTAACTAGTTAGCGGACCGA
  CGCGTTAAGCGGCCGCGAATTCAGATCCACAAGTTTGTACAAAAAAGCAGGCTTGTAAAA
  CGACGGCCAGTAACTATAACGGTCCTAAGGTAGCGAGGCCTGGGTGGCGAATTCGGCACG
  AGGCCGAGGCGACCTGGCCGCCGGCCGCTCCTCCGCGCGCTGTTCCGCACTTGCTGCCCT
  CGCCCGGCCCGGAGCGCCGCTGCCATGCGGCTGGCGCTGCTCTGGGCCCTGGGGCTCCTG
  GGCGCGGGCAGCCCTCTGCCTTCCTGGCCGCTCCCAAATATAGGTGGCACTGAGGAGCAG
  CAGGCAGAGTCAGAGAAGGCCCCGAGGGAGCCCTTGGAGCCCCAGGTCCTTCAGGACGAT
  CTCCCAATTAGCCTCAAAAAGGTGCTTCAGACCAGTCTGCCTGAGCCCCTGAGGATCAAG
  TTGGAGCTGGACGGTGACAGTCATATCCTGGAGCTGCTACAGAATAGGGAGTTGGTCCCA
  GGCCGCCCAACCCTGGTGTGGTACCAGCCCGATGGCACTCGGGTGGTCAGTGAGGGACAC
  ACTTTGGAGAACTGCTGCTACCCAGGGAAGAGTGCGGGGATATGCAGGCTCCTGGTGTCC
  ATCTGCACCTGCTCTGGGCTCAGAGCTTGGTGTCCTGACCCAGAGAGAAGCTATACCCTG
  AGCAGGGCTTGGGGACCTGTCAGGGTCCTCCCATTATTTCGCGAATCCAGAATCTCAACT
  GCCAGGCCCACTGTGCCTTGACCTGCGGATCTGTACACGTCAAAGCCCACCAAGCACCCC
  CCTGGGACACGCGCTCAAATCCCGGAAGGTCGGGTA
• Restriction Sites: Please inquire
• ACCN: NM_003815
• ORF Size: 2445 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003815.3, NP_003806.3
• RefSeq Size: 2823
• RefSeq ORF: 2445
• Locus ID: 8751
• Domains: Reprolysin, DISIN, Pep_M12B_propep, ACR
• Protein Families: Druggable Genome, Protease, Transmembrane
• Gene Summary: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (2) lacks two in-frame coding exons compared to variant 6. The resulting isoform (2) lacks an internal region, as compared to the longest isoform (6).