HIPPI (IFT57) (NM_018010) Human Untagged Clone

CAT#: SC321611

IFT57 (untagged)-Human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: IFT57
• Synonyms: ESRRBL1; HIPPI; MHS4R2; OFD18
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_018010.2 GTAACCGGTCGTGGCTGTACTGGCGGCGGCAGGGCTGGCGGCTTAGGCCGCAGAGGTCTG
  TGGGCCTGAGCCCACGCTGGACTCTGTCCGTTCTGCGATGACTGCTGCTCTGGCCGTCGT
  CACGACGTCGGGTTTGGAAGATGGGGTGCCTAGGTCCCGTGGCGAAGGGACCGGGGAAGT
  GGTCTTGGAGCGGGGGCCCGGCGCGGCCTACCACATGTTCGTGGTGATGGAGGACTTGGT
  GGAGAAGCTGAAGCTGCTCCGCTACGAGGAGGAGTTCCTCCGGAAGAGCAACCTGAAGGC
  CCCGTCCAGACACTATTTTGCACTGCCTACCAACCCTGGCGAACAGTTCTACATGTTTTG
  TACTCTTGCTGCTTGGTTGATTAATAAAGCGGGACGTCCCTTTGAGCAGCCTCAAGAATA
  TGATGACCCTAATGCAACAATATCTAACATACTATCCGAGCTTCGGTCATTTGGAAGAAC
  TGCAGATTTTCCTCCTTCAAAATTAAAGTCAGGTTATGGAGAACATGTATGCTATGTTCT
  TGATTGCTTCGCTGAAGAAGCATTGAAATATATTGGTTTCACCTGGAAAAGGCCAATATA
  CCCAGTAGAAGAATTAGAAGAAGAAAGCGTTGCAGAAGATGATGCAGAATTAACATTAAA
  TAAAGTGGATGAAGAATTTGTGGAAGAAGAGACAGATAATGAAGAAAACTTTATTGATCT
  CAACGTTTTAAAGGCCCAGACATATCACTTGGATATGAACGAGACTGCCAAACAAGAAGA
  TATTTTGGAATCCACAACAGATGCTGCAGAATGGAGCCTAGAAGTGGAACGTGTACTACC
  GCAACTGAAAGTCACGATTAGGACTGACAATAAGGATTGGAGAATCCATGTTGACCAAAT
  GCACCAGCACAGAAGTGGAATTGAATCTGCTCTAAAGGAGACCAAGGGATTTTTGGACAA
  ACTCCATAATGAAATTACTAGGACTTTGGAAAAGATCAGCAGCCGAGAAAAGTACATCAA
  CAATCAGCTTGAGAATTTGGTTCAAGAATATCGTGCAGCTCAAGCCCAGCTGAGTGAGGC
  AAAGGAGCGATACCAGCAGGGAAATGGAGGAGTGACGGAAAGAACCAGACTCCTCTCTGA
  GGTTATGGAAGAATTAGAAAAGGTAAAACAAGAAATGGAAGAAAAGGGCAGCAGCATGAC
  TGATGGTGCTCCTTTGGTGAAGATTAAACAGAGCTTAACAAAACTGAAGCAAGAAACTGT
  AGAGATGGACATTAGAATTGGCATTGTGGAACACACACTACTCCAATCAAAGCTGAAGGA
  GAAGTCCAACATGACTAGGAACATGCATGCCACAGTTATTCCAGAACCAGCAACAGGCTT
  TTATTAAAACATACTGGTTTTCATGTTTCTGATTAGTTGGGTTTTTTATATCAAACTATA
  TTTCATGTTGCATAGATTTCAAAACATAATTTTATGTTCAATGGGTATTTTTTTACATAT
  ACATACTCACATATTATATCATGGTGATTATGATGGTTAAAGCCTTTACACTGAATGTAA
  TGTTTAATAAAGAAATTACAAATTCTCACTTTCAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_018010.2 unedited
  GACATTTGTATACGACTCCTATAGGGCGGCTGGGCAATTCGGCACGCAGGGTAACCGGTC
  GTGGCTGTACTGGCGGCGGCAGGGCTGGCGGCTTAGGCCGCAGAGGTCTGTGGGCCTGAG
  CCCACGCTGGACTCTGTCCGTTCTGCGATGACTGCTGCTCTGGCCGTCGTCACGACGTCG
  GGTTTGGAAGATGGGGTGCCTAGGTCCCGTGGCGAAGGGACCGGGGAAGTGGTCTTGGAG
  CGGGGGCCCGGCGCGGCCTACCACATGTTCGTGGTGATGGAGGACTTGGTGGAGAAGCTG
  AAGCTGCTCCGCTACGAGGAGGAGTTCCTCCTTAAGAGCAACCTGAAGGCCCCGTCCAGA
  CACTATTTTGCACTGCCTACCAACCCTGGCGAACAGTTCTACATGTTTTGTACTCTTGCT
  GCTTGGTTGATTAATAAAGCGGGACGTCCCTTTGAGCAGCCTCAAGAATATGATGACCCT
  AATGCAACAATATCTAACATACTATCCGAGCTTCGGTCATTTGGAAGAACTGCAGATTTT
  CCTCCTTCAAAATTAAAGTCAGGTTATGGAGAACATGTATGCTATGTTCTTGATTGCTTC
  GCTGAAGAAGCATTGAAATATATTGGTTTCACCTGGAAAAGGCCAATATACCCAGTAGAA
  GAATTAGAAGAGAAAGCGTTGCAGAGATGATGCAGAATTAACATTAAATAAAGTGGATGA
  AGAATTTGTTGGAAGAAGGAGACAGATAATGAAGAAAACTTTATTGATCCTCAACGTTTT
  AAAAGGCCCAGAACATATCACCTTGGATATTGAACGGAGACTGCCAAACAAGAAGATTAT
  TTTGGGATCCACAACAGATGCTGCAGATGGGAGCCCTAGAGTGGAACGGTTGTACTACCC
  GCACTGAAAGTCACCGATTAGAACTGAACAATAGATTGGGGAGAATCATTGTGACAATGC
  ACCAGCCCAGATGGTATTTGATTCTCGGCTCTCTTAAGGGAGAACACAAGGGGA
• Restriction Sites: Please inquire
• ACCN: NM_018010
• ORF Size: 1290 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_018010.2, NP_060480.1
• RefSeq Size: 3052
• RefSeq ORF: 1290
• Locus ID: 55081
• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease
• Gene Summary: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. [UniProtKB/Swiss-Prot Function]