Fibromodulin (FMOD) (NM_002023) Human Untagged Clone

CAT#: SC321707

FMOD (untagged)-Human fibromodulin (FMOD)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FMOD
• Synonyms: FM; SLRR2E
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002023.3 CTCTCTCACACGTTCTCCAACCCAAGGAGGCCAGACAGAGGGACGTGGTCACTCTCTGAA
  AAGTTCAACTTGAGAGACAAAATGCAGTGGACCTCCCTCCTGCTGCTGGCAGGGCTCTTC
  TCCCTCTCCCAGGCCCAGTATGAAGATGACCCTCATTGGTGGTTCCACTACCTCCGCAGC
  CAGCAGTCCACCTACTACGATCCCTATGACCCTTACCCGTATGAGACCTACGAGCCTTAC
  CCCTATGGGGTGGATGAAGGGCCAGCCTACACCTACGGCTCTCCATCCCCTCCAGATCCC
  CGCGACTGCCCCCAGGAGTGCGACTGCCCACCCAACTTCCCCACGGCCATGTACTGTGAC
  AATCGCAACCTCAAGTACCTGCCCTTCGTTCCCTCCCGCATGAAGTATGTGTACTTCCAG
  AACAACCAGATCACCTCCATCCAGGAAGGCGTCTTTGACAATGCCACAGGGCTGCTCTGG
  ATTGCTCTCCACGGCAACCAGATCACCAGTGATAAGGTGGGCAGGAAGGTCTTCTCCAAG
  CTGAGGCACCTGGAGAGGCTGTACCTGGACCACAACAACCTGACCCGGATGCCCGGTCCC
  CTGCCTCGATCCCTGAGAGAGCTCCATCTCGACCACAACCAGATCTCACGGGTCCCCAAC
  AATGCTCTGGAGGGGCTGGAGAACCTCACGGCCTTGTACCTCCAACACAATGAGATCCAG
  GAAGTGGGCAGTTCCATGAGGGGCCTCCGGTCACTGATCTTGCTGGACCTGAGTTATAAC
  CACCTTCGGAAGGTGCCTGATGGGCTGCCCTCAGCTCTTGAGCAGCTGTACATGGAGCAC
  AACAATGTCTACACCGTCCCCGATAGCTACTTCCGGGGGGCGCCCAAGCTGCTGTATGTG
  CGGCTGTCCCACAACAGTCTAACCAACAATGGCCTGGCCTCCAACACCTTCAATTCCAGC
  AGCCTCCTTGAGCTAGACCTCTCCTACAACCAGCTGCAGAAGATCCCCCCAGTCAACACC
  AACCTGGAGAACCTCTACCTCCAAGGCAATAGGATCAATGAGTTCTCCATCAGCAGCTTC
  TGCACCGTGGTGGACGTCGTGAACTTCTCCAAGCTGCAGGTGCTGCGCCTGGACGGGAAC
  GAGATCAAGCGCAGCGCCATGCCTGCCGACGCGCCCCTCTGCCTGCGCCTTGCCAGCCTC
  ATCGAGATCTGAGCAGCCCTGGCACCGGGTACTGGGCGGAGAGCCCCCGTGGCATTTGGC
  TTGATGGTTTGGTTTGGCTTTTGCTGGAAGGTCCAGGATGGACCATGTGACAGAAGTCCA
  CGGGCACCCTCTGTAGTCTTCTTTCCTGTAGGTGGGGTTAGGGGGGGCGATCAGGGACAG
  GCAGCCTTCTGCTGAGGACATAGGCAGAAGCTCACTCTTTTCCAGGGACAGAAGTGGTGG
  TAGATGGAAGGATCCCTGGATGTTCCAACCCCATAAATCTCACGGCTCTTAAGTTCTTCC
  CAATGATCTGAGGTCATGGAACTTCAAAAGTGGCATGGGCAATAGTATATAACCATACTT
  TTCTAACAATCCCTGGCTGTCTGTGAGCAGCACTTGACAGCTCTCCCTCTGTGCTGGGCT
  GGTCGTGCAGTTACTCTGGGCTCCCATTTGTTGCTTCTCAAATATACCTCTTGCCCAGCT
  GCCTCTTCTGAAATCCACTTCACCCACTCCACTTTCCTCCACAGATGCCTCTTCTGTGCC
  TTAAGCAGAGTCAGGAGACCCCAAGGCATGTGATCATCTGCCCAGCAACCTGTGGAGACA
  ACCCACACTGTGTCTGAGGGTGAAAGGACACCAGGAGTCACTTCTATACCTCCCTAACCT
  CACCCCTGGAAAGCCACCAGATTGGAGGTCACCAGCATGATGATAATATTCATGACCTGA
  TGTGGGAGGAGACAGCCAACCTCAGGCTTAGATCAATGTATAGGGCTATATTTTGGCAGC
  TGGGTAGCTCTTTGAAGGTGGATAAGACTTCAGAAGAGGAAAGGCCAGACTTTGCTTACC
  ATCAGCATCTGCAATGGGCCAAACACACCTCAAATTGGCTGAGTTGAGAAAGCAGCCCCA
  GTAGTTCCATTCTTGCCCAGCACTTTCTGCATTCCAAACAGCATCCTACCTGGGTTTTTA
  TCCACAAAGGTAGCGGCCACATGGTTTTTAAAGTATGAGAAACACAGTTTGTCCTCTCCT
  TTTATCCAAGCAGGAAGATTCTATATCCTGATGGTAGAGACAGACTCCAGGCAGCCCTGG
  ACTTGCTAGCCCAAAGAAGGAGGATGTGGTTAATCTGTTTCACCTGGTTTGTCCTAAGGC
  CATAGTTAAAAAGTACCAGCTCTGGCTGGGGTCCGTGAAGCCCAGGCCAGGCAGCCAAAT
  CTTGCCTGTGCTGGGCATACAACCCTCTGCTTTCACATCTCTGAGCTATATCCTCATTAG
  TGAAGGTGGCTTTTGCTTTATAGTTTGGCTGGGGAGCACTTAATTCTTCCCATTTCAAAA
  GGTAATGTTGCCTGGGGCTTAACCCACCTGCCCTTTGGGCAAGGTTGGGACAAAGCCATC
  TGGGCAGTCAGGGGCAAGGACTGTTGGAGGAGAGTTAGCCCAAGTATAGGCTCTGCCCAG
  ATGCCATCACATCCCTGATACTGTGTATGCTTTGAAGCACCTTCCCTGAGAAGGGAAGAG
  GGGATCTTTGGACTAGGTTCTTGGCTCCAGACCTGGAATCCACAAAAGCCAAACCAGCTC
  ATTTCAACAAAGGAGCTCCGATGTGAGGGGCAAGGCTGCCCCCTGCCCCAGGGCTCTTCA
  GAAAGCATCTGCATGTGAACACCATCATGCCTTTATAAAGGATCCTTATTACAGGAAAAG
  CATGAGTGGTGGCTAACCTGACCAATAAAGTTATTTTATGATTGCAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_002023
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002023.3, NP_002014.2
• RefSeq Size: 3005 bp
• RefSeq ORF: 1131 bp
• Locus ID: 2331
• Cytogenetics: 1q32.1
• Domains: LRRNT, LRR, LRR_TYP, LRR_BAC, LRR_PS
• Protein Families: Druggable Genome, Secreted Protein
• Gene Summary: 'Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.