Kallikrein 6 (KLK6) (NM_001012964) Human Untagged Clone

CAT#: SC322327

KLK6 (untagged)-Human kallikrein-related peptidase 6 (KLK6), transcript variant B


  "NM_001012964" in other vectors (6)

Reconstitution Protocol

USD 420.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol KLK6
Synonyms Bssp; hK6; Klk7; PRSS9; PRSS18; SP59
Vector pCMV6-AC
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>OriGene sequence for SC322327 GGGAGGCCTGGGAGCTGGGGGTGTGTGTCTGGCAGTCCCTGCAGCCCTGGGCTCTGCGGC
CCCTGCGTCCTCCGCTTGGCTCTGCCACTGCATCTGAGTGTCTTCTCTCCTCACGGCTCC
CCGCATTTCTAACTCTTTCTGCCTCCTCGTCTCAAAGCTGTTCCTTCCCCCGACTCAAGA
ATCCCCGGAGGCCCGGAGGCCTGCAGCAGGAGCGGCCATGAAGAAGCTGATGGTGGTGCT
GAGTCTGATTGCTGCAGCCTGGGCAGAGGAGCAGAATAAGTTGGTGCATGGCGGACCCTG
CGACAAGACATCTCACCCCTACCAAGCTGCCCTCTACACCTCGGGCCACTTGCTCTGTGG
TGGGGTCCTTATCCATCCACTGTGGGTCCTCACAGCTGCCCACTGCAAAAAACCGAATCT
TCAGGTCTTCCTGGGGAAGCATAACCTTCGGCAAAGGGAGAGTTCCCAGGAGCAGAGTTC
TGTTGTCCGGGCTGTGATCCACCCTGACTATGATGCCGCCAGCCATGACCAGGACATCAT
GCTGTTGCGCCTGGCACGCCCAGCCAAACTCTCTGAACTCATCCAGCCCCTTCCCCTGGA
GAGGGACTGCTCAGCCAACACCACCAGCTGCCACATCCTGGGCTGGGGCAAGACAGCAGA
TGGTGATTTCCCTGACACCATCCAGTGTGCATACATCCACCTGGTGTCCCGTGAGGAGTG
TGAGCATGCCTACCCTGGCCAGATCACCCAGAACATGTTGTGTGCTGGGGATGAGAAGTA
CGGGAAGGATTCCTGCCAGGGTGATTCTGGGGGTCCGCTGGTATGTGGAGACCACCTCCG
AGGCCTTGTGTCATGGGGTAACATCCCCTGTGGATCAAAGGAGAAGCCAGGAGTCTACAC
CAACGTCTGCAGATACACGAACTGGATCCAAAAAACCATTCAGGCCAAGTGACCCTGACA
TGTGACATCTACCTCCCGACCTACCACCCCACTGGCTGGTTCCAGAACGTCTCTCACCTA
GACCTTGCCTCCCCTCCTCTCCTGCCCAGCTCTGACCCTGATGCTTAATAAACGCAGCGA
CGTGAGGGTCCTGATTCTCCCTGGTTTTACCCCAGCTCCATCCTTGCATCACTGGGGAGG
ACGTGATGAGTGAGGACTTGGGTCCTCGGTCTTACCCCCACCACTAAGAGAATACAGGAA
AATCCCTTCTAGGCATCTCCTCTCCCCAACCCTTCCACACGTTTGATTTCTTCCTGCAGA
GGCCCAGCCACGTGTCTGGAATCCCAGCTCCGCTGCTTACTGTCGGTGTCCCCTTGGGAT
GTACCTTTCTTCACTGCAGATTTCTCACCTGTAAGATGAAGATAAGGATGATACAGTCTC
CATAAGGCAGTGGCTGTTGGAAAGATTTAAGGTTTCACACCTATGACATACATGGAATAG
CACCTGGGCCACCATGCACTCAATAAAGAATGAATTTTATTATGAAAAAAAAAAAAAAAA
Restriction Sites Please inquire     
ACCN NM_001012964
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_001012964.1, NP_001012982.1
RefSeq Size 1527 bp
RefSeq ORF 735 bp
Locus ID 5653
Cytogenetics 19q13.41
Protein Families Druggable Genome, Protease, Secreted Protein
Gene Summary 'This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]'
Transcript Variant: This variant (B, also known as 1) differs in the 5' UTR compared to variant A. Both variants A and B encode the same isoform (A).

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