SLP76 (LCP2) (NM_005565) Human Untagged Clone

CAT#: SC322487

LCP2 (untagged)-Human lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) (LCP2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: LCP2
• Synonyms: SLP-76; SLP76
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322487 GACATCGGCTCCAACAGGGGTGTTCCACAGGGTAGCTGGGAGTTGGAAGAGCCAAGAACG
  CCTCCGAGCTCTGGATTTGAGCTTCTCTGCCCATGGGTGAAGCGCCCATGCTCAGCTTGT
  GAGCTTCTTCCCGGGAGAGCAGCCATGGCACTGAGGAATGTGCCCTTTCGCTCAGAGGTC
  CTGGGCTGGGACCCCGACAGCCTTGCTGACTATTTCAAGAAGCTCAACTATAAGGACTGT
  GAGAAGGCAGTGAAGAAGTACCACATCGATGGGGCTCGCTTCTTGAACCTGACAGAAAAT
  GACATCCAGAAGTTCCCCAAGCTCCGGGTGCCGATTCTCAGTAAGTTAAGTCAGGAAATC
  AACAAGAACGAAGAGAGGAGGAGCATCTTCACACGCAAACCCCAAGTCCCGCGGTTTCCT
  GAAGAGACAGAAAGCCACGAAGAGGACAATGGGGGCTGGTCGTCCTTTGAAGAAGACGAT
  TATGAAAGTCCCAATGATGACCAGGATGGGGAGGATGATGGAGACTATGAGTCCCCCAAT
  GAGGAGGAAGAGGCACCCGTGGAAGATGACGCGGATTATGAGCCGCCACCCTCCAATGAC
  GAGGAAGCTCTGCAGAACTCCATCCTGCCTGCCAAGCCTTTCCCCAACTCCAACTCCATG
  TACATCGACCGGCCCCCCTCTGGGAAAACCCCCCAGCAGCCTCCTGTGCCCCCCCAGAGA
  CCGATGGCCGCCCTCCCGCCCCCACCAGCCGGCCGGAATCACTCGCCACTGCCCCCACCC
  CAGACCAACCACGAAGAACCCAGCAGAAGCAGAAACCACAAAACGGCAAAGCTCCCTGCT
  CCTTCAATAGACAGAAGCACGAAACCTCCCCTAGATCGTTCATTAGCTCCGTTTGATAGA
  GAACCCTTCACACTAGGAAAGAAACCACCATTTTCTGACAAGCCCTCGATTCCAGCGGGA
  AGGTCACTCGGGGAGCATTTACCCAAGATTCAAAAGCCTCCTTTACCACCGACCACGGAA
  AGACATGAAAGGAGCAGCCCCCTGCCAGGGAAGAAGCCACCTGTGCCAAAGCATGGATGG
  GGACCAGACAGAAGAGAGAATGATGAAGATGATGTGCATCAGAGACCTTTGCCCCAGCCA
  GCACTACTTCCTATGAGCTCCAACACTTTCCCTTCAAGATCTACTAAGCCAAGTCCCATG
  AACCCTCTCCCATCCTCTCACATGCCTGGAGCATTCTCAGAAAGTAACAGCAGTTTTCCA
  CAGAGTGCCTCCCTGCCACCATACTTCTCTCAAGGCCCTAGCAACAGACCACCTATCAGA
  GCCGAAGGCAGAAACTTCCCCTTGCCACTTCCAAACAAACCTCGGCCCCCATCCCCCGCG
  GAGGAAGAGAATTCATTAAATGAAGAGTGGTACGTTTCTTATATTACCCGACCAGAGGCA
  GAAGCTGCTCTTAGAAAGATAAACCAGGATGGCACATTTCTGGTCAGAGACAGCTCTAAA
  AAAACAACAACCAATCCATATGTCCTCATGGTGTTGTACAAAGATAAAGTTTACAACATC
  CAGATCCGTTATCAGAAGGAAAGTCAAGTTTACTTGTTGGGAACTGGACTCCGAGGGAAA
  GAGGACTTTCTGTCTGTGTCAGATATTATTGACTACTTCAGGAAAATGCCACTTCTGCTC
  ATTGATGGGAAAAACCGAGGTTCCAGATACCAGTGCACATTAACGCATGCTGCAGGGTAC
  CCATAGCAAGTTATAGCCGAGCAAATGAACCGTCCTCCTGCCTCTGTTGCCAACACGAGA
  TCAATCAGCCTTGGTCAATGGACAAACACTTAGGACTGAACTGAACCCCTCCCCATGAAC
  ACAAGGGTTTTATCCTTTCCTTTAAAAACAGTGTTTGAAATGAAGACTGTCAACTATCCC
  ATAATTTATTTATTCTTCTTCAATGTTTGTAAAGTGCATGAGTCATGTTCACACTTGAAG
  TCTAGTAGTGCACTGTAATAATTCATTTTTTAAAAGATTATTTAATGCCCATTTCAAAAT
  ACAGTAGTTTACACAGCTACAGAAACAATTTGGGGCAAGTTTTAAAACACTGAAACAGTA
  ATAGTTATTGGTGTCACATAAAACTGATTTGTTTTTTACAGCCAAACCTCTGTCAGTCAG
  AGGCATTCATTAGTTTTATACATGTAATTTGAAAATCACTAAACCTCGTTTTCTCAGCAG
  CAATAATTTAAGAGGCTTCAAAAATATAATTTCACTCTTATTTAGTATTTTTTCCTGGGG
  GCATTTTTACGTAATTTTTTTATGAAAAGACAAATGCATGTTGAGATAACTTCTGGGATT
  AAAATAGTCTTTTGCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_005565
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005565.3, NP_005556.1
• RefSeq Size: 2472 bp
• RefSeq ORF: 1602 bp
• Locus ID: 3937
• Cytogenetics: 5q35.1
• Domains: SH2, SAM
• Protein Pathways: Fc epsilon RI signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway
• Gene Summary: 'This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]'