Lubricin (PRG4) (NM_001127710) Human Untagged Clone

CAT#: SC323274

PRG4 (untagged)-Human proteoglycan 4 (PRG4), transcript variant D

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PRG4
• Synonyms: CACP; HAPO; JCAP; MSF; SZP
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001127710, the custom clone sequence may differ by one or more nucleotides
  ATGGCATGGAAAACACTTCCCATTTACCTGTTGTTGCTGCTGTCTGTTTTCGTGATTCAG
  CAAGTTTCATCTCAAGAGCTTTCCTGTAAAGGCCGCTGCTTTGAGTCCTTCGAGAGAGGG
  AGGGAGTGTGACTGCGACGCCCAATGTAAGAAGTATGACAAGTGCTGTCCCGATTATGAG
  AGTTTCTGTGCAGAAGTAAAAGATAACAAGAAGAACAGAACTAAAAAGAAACCTACCCCC
  AAACCACCAGTTGTAGATGAAGCTGGAAGTGGATTGGACAATGGTGACTTCAAGGTCACA
  ACTCCTGACACGTCTACCACCCAACACAATAAAGTCAGCACATCTCCCAAGATCACAACA
  GCAAAACCAATAAATCCCAGACCCAGTCTTCCACCTAATTCTGATACATCTAAAGAGACG
  TCTTTGACAGTGAATAAAGAGACAACAGTTGAAACTAAAGAAACTACTACAACAAATAAA
  CAGACTTCAACTGATGGAAAAGAGAAGACTACTTCCGCTAAAGAGACACAAAGTATAGAG
  AAAACATCTGCTAAAGATTTAGCACCCACATCTAAAGTGCTGGCTAAACCTACACCCAAA
  GCTGAAACTACAACCAAAGGCCCTGCTCTCACCACTCCCAAGGAGCCCACGCCCACCACT
  CCCAAGGAGCCTGCATCTACCACACCCAAAGAGCCCACACCTACCACCATCAAGTCTGCA
  CCCACCACCCCCAAGGAGCCTGCACCCACCACCACCAAGTCTGCACCCACCACTCCCAAG
  GAGCCTGCACCCACCACCACCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTGCACCC
  ACCACCACCAAGGAGCCTGCACCCACCACCACCAAGTCTGCACCCACCACTCCCAAGGAG
  CCTGCACCCACCACCCCCAAGAAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACC
  ACTCCCAAGGAGCCTACACCCACCACTCCCAAGGAGCCTGCACCCACCACCAAGGAGCCT
  GCACCCACCACTCCCAAAGAGCCTGCACCCACTGCCCCCAAGAAGCCTGCCCCAACTACC
  CCCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCACCAAGGAGCCT
  TCACCCACCACTCCCAAGGAGCCTGCACCCACCACCACCAAGTCTGCACCCACCACTACC
  AAGGAGCCTGCACCCACCACTACCAAGTCTGCACCCACCACTCCCAAGGAGCCTTCACCC
  ACCACCACCAAGGAGCCTGCACCCACCACTCCCAAGGAGCCTGCACCCACCACCCCCAAG
  AAGCCTGCCCCAACTACCCCCAAGGAGCCTGCACCCACCACTCCCAAGGAACCTGCACCC
  ACCACCACCAAGAAGCCTGCACCCACCACTCCCAAAGAGCCTGCCCCAACTACCCCCAAG
  GAGACTGCACCCACCACCCCCAAGAAGCTCACGCCCACCACCCCCGAGAAGCTCGCACCC
  ACCACCCCTGAGAAGCCCGCACCCACCACCCCTGAGGAGCTCGCACCCACCACCCCTGAG
  GAGCCCACACCCACCACCCCTGAGGAGCCTGCTCCCACCACTCCCAAGGCAGCGGCTCCC
  AACACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAG
  GAGCCTGCTCCAACTACCCCTAAGGAGACTGCTCCAACTACCCCTAAAGGGACTGCTCCA
  ACTACCCTCAAGGAACCTGCACCCACTACTCCCAAGAAGCCTGCCCCCAAGGAGCTTGCA
  CCCACCACCACCAAGGAGCCCACATCCACCACCTGTGACAAGCCCGCTCCAACTACCCCT
  AAGGGGACTGCTCCAACTACCCCTAAGGAGCCTGCTCCAACTACCCCTAAGGAGCCTGCT
  CCAACTACCCCTAAGGGGACTGCTCCAACTACCCTCAAGGAACCTGCACCCACTACTCCC
  AAGAAGCCTGCCCCCAAGGAGCTTGCACCCACCACCACCAAGGGGCCCACATCCACCACC
  TCTGACAAGCCTGCTCCAACTACACCTAAGGAGACTGCTCCAACTACCCCCAAGGAGCCT
  GCACCCACTACCCCCAAGAAGCCTGCTCCAACTACTCCTGAGACACCTCCTCCAACCACT
  TCAGAGGTCTCTACTCCAACTACCACCAAGGAGCCTACCACTATCCACAAAAGCCCTGAT
  GAATCAACTCCTGAGCTTTCTGCAGAACCCACACCAAAAGCTCTTGAAAACAGTCCCAAG
  GAACCTGGTGTACCTACAACTAAGACTCCTGCAGCGACTAAACCTGAAATGACTACAACA
  GCTAAAGACAAGACAACAGAAAGAGACTTACGTACTACACCTGAAACTACAACTGCTGCA
  CCTAAGATGACAAAAGAGACAGCAACTACAACAGAAAAAACTACCGAATCCAAAATAACA
  GCTACAACCACACAAGTAACATCTACCACAACTCAAGATACCACACCATTCAAAATTACT
  ACTCTTAAAACAACTACTCTTGCACCCAAAGTAACTACAACAAAAAAGACAATTACTACC
  ACTGAGATTATGAACAAACCTGAAGAAACAGCTAAACCAAAAGACAGAGCTACTAATTCT
  AAAGCGACAACTCCTAAACCTCAAAAGCCAACCAAAGCACCCAAAAAACCCACTTCTACC
  AAAAAGCCAAAAACAATGCCTAGAGTGAGAAAACCAAAGACGACACCAACTCCCCGCAAG
  ATGACATCAACAATGCCAGAATTGAACCCTACCTCAAGAATAGCAGAAGCCATGCTCCAA
  ACCACCACCAGACCTAACCAAACTCCAAACTCCAAACTAGTTGAAGTAAATCCAAAGAGT
  GAAGATGCAGGTGGTGCTGAAGGAGAAACACCTCATATGCTTCTCAGGCCCCATGTGTTC
  ATGCCTGAAGTTACTCCCGACATGGATTACTTACCGAGAGTACCCAATCAAGGCATTATC
  ATCAATCCCATGCTTTCCGATGAGACCAATATATGCAATGGTAAGCCAGTAGATGGACTG
  ACTACTTTGCGCAATGGGACATTAGTTGCATTCCGAGGTCATTATTTCTGGATGCTAAGT
  CCATTCAGTCCACCATCTCCAGCTCGCAGAATTACTGAAGTTTGGGGTATTCCTTCCCCC
  ATTGATACTGTTTTTACTAGGTGCAACTGTGAAGGAAAAACTTTCTTCTTTAAGGATTCT
  CAGTACTGGCGTTTTACCAATGATATAAAAGATGCAGGGTACCCCAAACCAATTTTCAAA
  GGATTTGGAGGACTAACTGGACAAATAGTGGCAGCGCTTTCAACAGCTAAATATAAGAAC
  TGGCCTGAATCTGTGTATTTTTTCAAGAGAGGTGGCAGCATTCAGCAGTATATTTATAAA
  CAGGAACCTGTACAGAAGTGCCCTGGAAGAAGGCCTGCTCTAAATTATCCAGTGTATGGA
  GAAACGACACAGGTTAGGAGACGTCGCTTTGAACGTGCTATAGGACCTTCTCAAACACAC
  ACCATCAGAATTCAATATTCACCTGCCAGACTGGCTTATCAAGACAAAGGTGTCCTTCAT
  AATGAAGTTAAAGTGAGTATACTGTGGAGAGGACTTCCAAATGTGGTTACCTCAGCTATA
  TCACTGCCCAACATCAGAAAACCTGACGGCTATGATTACTATGCCTTTTCTAAAGATCAA
  TACTATAACATTGATGTGCCTAGTAGAACAGCAAGAGCAATTACTACTCGTTCTGGGCAG
  ACCTTATCCAAAGTCTGGTACAACTGTCCT
  
• Restriction Sites: Please inquire
• ACCN: NM_001127710
• ORF Size: 3813 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001127710.1, NP_001121182.1
• RefSeq Size: 4657
• RefSeq ORF: 3813
• Locus ID: 10216
• Gene Summary: The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
  Transcript Variant: This variant (D, also known as V3) lacks three alternate in-frame exons in the 5' coding region, compared to variant A. The resulting protein (isoform D) is shorter than isoform A. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments.