NTE (PNPLA6) (NM_006702) Human Untagged Clone

CAT#: SC323842

PNPLA6 (untagged)-Human patatin-like phospholipase domain containing 6 (PNPLA6), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PNPLA6
• Synonyms: BNHS; iPLA2delta; LNMS; NTE; NTEMND; OMCS; SPG39; sws
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_006702.3 GCGGAACGCTAGCGGTGTTGGCGCGGAGTGGACCCCGGCTGCGGCCCCTGGCAATGGCGC
  CACCATCGGTCCCGGAGTCCCAGTGATGCTCTGTGCCATAGAGCCCCCATAACTTCACTA
  CTACGTGATAGTAAATCCCCGGCAAAAACCAGCAGCGCCTTGCAAGCCCACGCCACCCCA
  AGCATCCCAGGACTCTTCTGAAACGACTCCGGGCTACCAGATCGGCCGTCCAGCTGGAAT
  CAACCGATGGAGGCTCCGCTGCAAACTGGAATGGTGCTTGGCGTGATGATCGGGGCCGGA
  GTGGCGGTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCA
  AAAACCCCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTC
  TATGGCCGGAAGATTATGCGGAAGGTGTCACAATCCACCTCCTCCCTCGTGGATACCTCT
  GTCTCCGCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAG
  AAGATCCTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCA
  GTGCTAGAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTG
  CTTTATATGCTCAAGAACGTCCGGGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAG
  CTCTGCCGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGC
  CAGCCAGATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGG
  CCTGACGGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTT
  CTCAGCATCCTGGATGTCATCACCGGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGG
  GCGGCCCGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACC
  AAGTACCCGGAGAGCTTGGTGCGGGTCGTGCAGATCATCATGGTGCGGCTGCAGCGAGTC
  ACCTTCCTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCACGAGATC
  CAGCCCCTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGC
  TCCAAGAGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCA
  CCCGATCCCACCGGGGCCCCGCTGCCTGGACCTACAGGGGACCCTGTGAAGCCCACATCC
  CTGGAAACCCCCTCGCCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCA
  GGCTTGCAGGGTGGCCCCCGCTCCGACTTCGACATGGCCTATGAGCGTGGCCGGATCTCC
  GTGTCCCTGCAAGAAGAGGCCTCCGGGGGGTCCCTGGCAGCCCCCGCTCGGACCCCCACT
  CAGGAGCCTCGTGAGCAGCCGGCAGGCGCCTGTGAATACAGCTACTGTGAGGATGAGTCG
  GCCACTGGTGGCTGCCCTTTCGGGCCCTACCAGGGCCGCCAGACCAGCAGCATCTTCGAG
  GCAGCAAAGCAGGAGCTGGCCAAGCTGATGCGGATTGAGGACCCCTCCCTCCTGAACAGC
  AGAGTCTTGCTGCACCACGCCAAAGCTGGCACCATCATTGCCCGCCAGGGAGACCAGGAC
  GTGAGCCTGCACTTCGTGCTCTGGGGCTGCCTGCACGTGTACCAGCGCATGATCGACAAG
  GCGGAGGACGTGTGCCTGTTCGTAGCGCAGCCCGGGGAACTGGTGGGGCAGCTGGCGGTG
  CTCACTGGCGAACCTCTCATCTTCACACTGCGAGCCCAACGCGACTGCACCTTCCTGCGG
  ATCTCCAAGTCCGACTTCTATGAGATCATGCGCGCACAGCCCAGTGTGGTGCTGAGTGCG
  GCGCACACGGTGGCAGCCAGGATGTCGCCCTTCGTGCGCCAGATGGACTTCGCCATCGAC
  TGGACTGCAGTGGAGGCGGGACGCGCGCTGTACAGGCAGGGCGACCGCTCCGACTGCACT
  TACATCGTGCTCAATGGGCGGCTGCGTAGCGTGATCCAGCGAGGCAGTGGCAAGAAGGAG
  CTGGTGGGCGAGTACGGCCGCGGCGACCTCATCGGCGTGGTGGAGGCACTGACCCGGCAG
  CCGCGAGCCACGACGGTGCACGCGGTGCGCGACACGGAGCTGGCCAAGCTTCCCGAGGGC
  ACCTTGGGTCACATCAAACGCCGGTACCCGCAGGTCGTGACCCGCCTTATCCACCTACTG
  AGCCAGAAAATTCTAGGGAATTTGCAGCAGCTGCAAGGACCCTTCCCAGCAGGCTCTGGG
  TTGGGTGTGCCCCCACACTCGGAACTCACCAACCCAGCCAGCAACCTGGCAACTGTGGCA
  ATCCTGCCTGTGTGTGCTGAGGTCCCCATGGTGGCCTTCACGCTGGAGCTGCAGCACGCC
  CTGCAGGCCATCGGTCCGACGCTACTCCTTAACAGTGACATCATCCGGGCACGCCTGGGG
  GCCTCCGCACTGGATAGCATCCAAGAGTTCCGGCTGTCAGGGTGGCTGGCCCAGCAGGAG
  GATGCACACCGTATCGTACTCTACCAGACGGACGCCTCGCTGACGCCCTGGACCGTGCGC
  TGCCTGCGACAGGCCGACTGCATCCTCATTGTGGGCCTGGGGGACCAGGAGCCTACCCTC
  GGCCAGCTGGAGCAGATGCTGGAGAACACGGCTGTGCGCGCCCTTAAGCAGCTAGTCCTG
  CTCCACCGAGAGGAGGGCGCGGGCCCCACGCGCACCGTGGAGTGGCTAAATATGCGCAGC
  TGGTGCTCGGGGCACCTGCACCTGCGCTGTCCGCGCCGCCTCTTTTCGCGCCGCAGCCCT
  GCCAAGCTGCATGAGCTCTACGAGAAGGTTTTCTCCAGGCGCGCGGACCGGCACAGCGAC
  TTCTCCCGCTTGGCGAGGGTGCTCACGGGGAACACCATTGCCCTTGTGCTAGGCGGGGGC
  GGGGCCAGGGGCTGCTCGCACATCGGAGTACTAAAGGCATTAGAGGAGGCGGGGGTCCCC
  GTGGACCTGGTGGGCGGCACGTCCATTGGCTCTTTCATCGGAGCGTTGTACGCGGAGGAG
  CGCAGCGCCAGCCGCACGAGGCAGCGGGCCCGGGAGTGGGCCAAGAGCATGACTTCGGTG
  CTGGAACCTGTGTTGGACCTCACGTACCCAGTCACCTCCATGTTCACTGGGTCTGCCTTT
  AACCGCAGCATCCATCGGGTCTTCCAGGATAAGCAGATTGAGGACCTGTGGCTGCCTTAC
  TTCAACGTGACCACAGATATCACCGCCTCAGCCATGCGAGTCCACAAAGATGGCTCCCTG
  TGGCGGTACGTGCGCGCCAGCATGACGCTGTCGGGCTACCTGCCCCCGCTGTGCGACCCC
  AAGGACGGGCACCTACTCATGGATGGCGGCTACATCAACAATCTGCCAGCGGACATCGCC
  CGCAGCATGGGTGCCAAAACGGTCATCGCCATTGACGTGGGGAGCCAGGATGAGACGGAC
  CTCAGCACCTACGGGGACAGCCTGTCCGGCTGGTGGCTGCTGTGGAAGCGGCTGAATCCC
  TGGGCTGACAAGGTAAAGGTTCCAGACATGGCTGAAATCCAGTCCCGCCTGGCCTACGTG
  TCCTGTGTGCGGCAGCTAGAGGTTGTCAAGTCCAGCTCCTACTGCGAGTACCTGCGCCCG
  CCCATCGACTGCTTCAAGACCATGGACTTTGGGAAGTTCGACCAGATCTATGATGTGGGC
  TACCAGTACGGGAAGGCGGTGTTTGGAGGCTGGAGCCGTGGCAACGTCATTGAGAAAATG
  CTCACAGACCGGCGGTCTACAGACCTTAATGAGAGCCGCCGTGCAGACGTGCTTGCCTTC
  CCAAGCTCTGGCTTCACTGACTTGGCAGAGATTGTGTCCCGGATTGAGCCCCCCACGAGC
  TATGTCTCTGATGGCTGTGCTGACGGAGAGGAGTCAGATTGTCTGACAGAGTATGAGGAG
  GACGCCGGACCCGACTGCTCGAGGGATGAAGGGGGGTCCCCCGAGGGCGCAAGCCCCAGC
  ACTGCCTCCGAGATGGAGGAGGAGAAGTCGATTCTCCGGCAACGACGCTGTCTGCCCCAG
  GAGCCGCCCGGCTCAGCCACAGATGCCTGAGGACCTCGACAGGGGTCACCCCCTCCCTCC
  CACCCCTGGACTGGGCTGGGGGTGGCCCCGTGGGGGTAGCTCACTCCCCCTCCTGCTGCT
  ATGCCTGTGACCCCCGCGGCCCACACACTGGACTGACCTGCCCTGAGCGGGGATGCAGTG
  TTGCACTGATGACTTGACCAGCCCCTCCCCCAATAAACTCGCCTCTTGGAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006702.3 unedited
  GACCATTGTATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCCG
  GAATTCCCGGGATATCGTCGACCCACGCGTCCGGCGGAACGCTAGCGGTGTTGGCGCGGA
  GTGGACCCCGGCTGCGGCCCCTGGCAATGGCGCCACCATCGGTCCCGGAGTCCCAGTGAT
  GCTCTGTGCCATAGAGCCCCCATAACTTCACTACTACGTGATAGTAAATCCCCGGCAAAA
  ACCAGCAGCGCCTTGCAAGCCCACGCCACCCCAAGCATCCCAGGACTCTTCTGAAACGAC
  TCCGGGCTACCAGATCGGCCGTCCAGCTGGAATCAACCGATGGAGGCTCCGCTGCAAACT
  GGAATGGTGCTTGGCGTGATGATCGGGGCCGGAGTGGCGGTGGTGGTCACGGCCGTGCTC
  ATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAAAAACCCCAGCCCCGGATGGCCCCCGG
  TATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGCCGGAAGATTATGCGGAAGGTG
  TCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCCGCCACCTCCCGGCCACGCATG
  AGGAAGAAACTGAAGATGCTCAACATTGCCAAGAAGATCCTGCGCATCCAGAAAGAGACG
  CCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTAGAAGCTGACCTGACCGAGGGC
  GACCTGCTAACTCCCATCTGCCCTCTGAAGTGCTTTATATGCTCAAGACGTCCGGGTGCT
  GGGCCACTTCGAGAGCCACTCTCCTGAGCTCTGCCGCCACATGGTCTCAGCGCTGGCCAG
  TGACTACGTTCTTCGGCCGGGCAGCCAGATGCCAGCATCTACGTGTGCAGAACGACTGCT
  GAGCTTTGTCTGCAGACTGACGGCAAGATGGTTGGTGAAGAATTGCTCTGGGGACACGCG
  GTCCAACAGGCTCTTTTCGCAGGC
• Restriction Sites: ECoRI-NOT
• ACCN: NM_006702
• ORF Size: 3984 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_006702.3, NP_006693.3
• RefSeq Size: 4466
• RefSeq ORF: 3984
• Locus ID: 10908
• Domains: cNMP, Patatin
• Protein Families: Transmembrane
• Gene Summary: This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment near the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.