BCAR3 (NM_003567) Human Untagged Clone

CAT#: SC324095

BCAR3 (untagged)-Human breast cancer anti-estrogen resistance 3 (BCAR3)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BCAR3
• Synonyms: AND-34; NSP2; SH2D3B
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_003567.2 CCACGCGTCCGGCGTCCCCAGCTCCGGGAGCAGCCGCGGCGCGGGCGGTGCGAGGCCGGC
  CGCGCGGCGCCTTTGAGCCCCAGCCGGAGGTCCAGAGATCCTGAGAGCCCGAGCGCCCAG
  CGCCGCGCCGGGAGAGTTGAGAATTATGGCTGCAGGAAAATTTGCAAGCCTTCCCAGAAA
  CATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCCATGGACCTTCTGAGCAGCAGGTC
  CCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGATGTGTCTATACATGGCACCCTTCC
  ACGGAAGAAAAAAGGTCCTCCTCCCATAAGGTCCTGTGATGACTTCAGTCACATGGGCAC
  CCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCTGTGACCCAGGATGGCATCCAGGA
  GAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACCTTCAGGGATCCACATCTTCTGGA
  CCCAACTGTGGAATATGTGAAGTTCTCCAAGGAGAGGCACATCATGGACAGGACCCCCGA
  GAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTGAGCAGCGAGGACCTGCGCAGCCA
  TGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCTGAAAACCTTGTGCAGCGAGATGG
  TGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGGAACTTTGTCCTGACCTGTCAGTG
  GAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACAGTTCTGCGACTCAGCGAGGCCTA
  CAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTCGACTCCATCCCCGGCCTGGTGCG
  CTGCTACGTGGGCAACCGCCGGCCCATCTCCCAGCAGAGTGGCGCCATCATCTTCCAGCC
  CATCAACAGGACGGTGCCTCTGCGGTGCCTGGAGGAGCATTATGGCACCTCCCCAGGCCA
  GGCCCGGGAGGGCAGCCTCACCAAGGGAAGGCCGGATGTGGCCAAGAGGCTGAGCCTCAC
  CATGGGTGGCGTCCAGGCCCGAGAGCAGAATTTGCCCAGGGGAAACCTCCTCAGAAACAA
  AGAAAAGAGTGGTAGCCAGCCCGCCTGCCTGGATCACATGCAGGACAGAAGAGCCTTGTC
  CCTCAAAGCCCACCAGTCAGAGAGCTACCTGCCGATTGGCTGCAAGCTGCCACCTCAGTC
  CTCGGGTGTGGACACAAGCCCCTGCCCAAACTCACCTGTGTTCAGGACGGGAAGCGAGCC
  TGCCCTGAGCCCAGCAGTGGTTCGGAGGGTCTCCTCAGACGCCAGGGCTGGGGAGGCGCT
  GAGGGGATCAGACAGTCAACTGTGCCCTAAGCCCCCGCCTAAGCCCTGCAAGGTGCCGTT
  CCTCAAGGTTCCCTCGTCTCCCTCTGCCTGGCTCAACTCAGAGGCCAACTACTGTGAACT
  GAACCCAGCGTTTGCCACAGGCTGCGGCAGGGGAGCAAAGCTACCCTCATGTGCCCAGGG
  AAGCCACACAGAACTGCTCACAGCCAAGCAGAATGAGGCGCCAGGTCCCCGGAACTCTGG
  CGTCAACTACTTGATCCTTGATGATGATGACAGGGAAAGACCTTGGGAACCTGCGGCAGC
  TCAGATGGAGAAGGGGCAGTGGGACAAGGGCGAGTTTGTGACGCCCCTCCTGGAGACTGT
  CTCCTCCTTCAGGCCCAACGAGTTTGAGTCAAAGTTCCTTCCCCCTGAGAATAAGCCCCT
  GGAAACAGCAATGTTGAAACGTGCAAAAGAACTGTTCACCAACAACGACCCCAAGGTCAT
  CGCCCAGCACGTACTGAGCATGGACTGCAGGGTTGCTAGGATACTTGGAGTCTCTGAAGA
  GATGAGGAGGAACATGGGGGTGAGCTCAGGCCTGGAACTCATTACCTTGCCTCACGGACA
  CCAGCTGCGCCTGGACATAATTGAAAGACACAACACAATGGCCATCGGCATTGCAGTGGA
  CATTCTGGGATGCACGGGCACTTTGGAGGACCGAGCGGCCACTCTGAGTAAGATCATCCA
  GGTGGCGGTGGAACTGAAGGATTCCATGGGGGACCTCTATTCCTTCTCAGCTCTCATGAA
  AGCCCTGGAAATGCCACAGATCACAAGGTTAGAAAAGACGTGGACTGCTCTGCGGCACCA
  GTACACCCAAACTGCCATTCTCTATGAGAAACAGCTGAAGCCCTTCAGCAAACTCCTGCA
  TGAAGGCAGAGAGTCCACATGTGTTCCCCCAAACAATGTATCAGTCCCACTGCTGATGCC
  GCTTGTGACGTTAATGGAGCGCCAGGCTGTGACTTTTGAAGGAACCGACATGTGGGAAAA
  AAACGACCAGAGCTGTGAAATCATGCTGAACCATTTGGCAACAGCGCGATTCATGGCCGA
  GGCTGCAGACAGCTACCGGATGAATGCTGAGAGGATCCTGGCAGGTTTTCAACCAGATGA
  AGAAATGAATGAAATCTGCAAGACTGAATTTCAAATGCGATTGCTATGGGGCAGCAAAGG
  TGCACAAGTCAATCAGACAGAGAGATATGAGAAATTCAACCAGATTTTAACTGCCCTCTC
  GCGTAAATTGGAACCTCCTCCTGTAAAGCAGGCAGAGCTTTGATAACTCTCCAGAGAACC
  TTTAGAATATCTTTTCAAGTTTCCCCAGCTTCATCTTTGGGAAAGCTTACTGTTTTTGAT
  AAAGTAATAATGTGCAAATCTGACAATATACAAGCTTTTAGTATCCACAGGATATTAAAC
  GTGTAAATTGCACAGAGCACACTTATTTATGAATTGTCTAAAGTTACTACTGATTTTAAA
  ATGAATAATTTATTATTAAGGTAACTACTGCTAATGTTGATCAGCAAATTTAAGAGAAGA
  CCTAGCTATGTTGGCTGGTTGCTTTCTATTATCATGGTATTTGACCATTTTAGTTTTAAT
  TCCATGTCAGATAAGTGTAAATAGAAGAGTTTAAAAGCATGAAACATTTCAGAAGGTATC
  AGTTATATGATATTCTTTAAACAAATATGAAAAATGTAAATACTCATGAATGAAAATACA
  TCTTTTTGTGAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_003567.2 unedited
  GACATTTGTAATACGACTCCTATAGGGCGGCCGGCGATCGCGGCGCGCCGGTACCGGTCC
  GGAATTCCCGGGATATCGTCGACCCACGCGTCCGGCGTCCCCAGCTCCGGGAGCAGCCGC
  GGCGCGGGCGGTGCGAGGCCGGCCGCGCGGCGCCTTTGAGCCCCAGCCGGAGGTCCAGAG
  ATCCTGAGAGCCCGAGCGCCCAGCGCCGCGCCGGGAGAGTTGAGAATTATGGCTGCAGGA
  AAATTTGCAAGCCTTCCCAGAAACATGCCGGTGAATCACCAGTTCCCCCTGGCCTCATCC
  ATGGACCTTCTGAGCAGCAGGTCCCCTCTCGCTGAGCATCGCCCAGATGCCTATCAAGAT
  GTGTCTATACATGGCACCCTTCCACGGAAGAAAAAAGGTCCTCCTCCCATAAGGTCCTGT
  GATGACTTCAGTCACATGGGCACCCTCCCCCACTCCAAATCCCCACGGCAGAACTCGCCT
  GTGACCCAGGATGGCATCCAGGAGAGCCCATGGCAGGACCGGCACGGCGAAACCTTCACC
  TTCAGGGATCCACATCTTCTGGACCCAACTGTGGAATATGTGAAGTTCTCCAAGGAGAGG
  CACATCATGGACAGGACCCCCGAGAAACTGAAGAAGGAGCTGGAGGAGGAGCTGCTCCTG
  AGCAGCGAGGACCTGCGCAGCCATGCCTGGTACCACGGCCGCATCCCCCGACAGGTGTCT
  GAAAACCTTGTGCAGCGAGATGGTGACTTCCTAGTTCGTGACTCTCTGTCCAGCCCTGGG
  AACTTTGTCCTGACCTGTCAGTGGAAGAACCTCGCTCAGCACTTCAAAATCAACCGGACA
  GTTCTGCGACTCAGCGAGGCCTACAGCCGCGTGCAGTACCAGTTCGAGATGGAGAGCTTC
  GACTCCATCCCGCTTGGTGCGCTGCTACGTGGTCAACGGCCGGCCATTCTCCAAGCGAAG
  TGGCCGCCATCTATCTTCCAGCCCACTTACACACG
• Restriction Sites: ECoRI-NOT
• ACCN: NM_003567
• ORF Size: 2478 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_003567.2, NP_003558.1
• RefSeq Size: 3184
• RefSeq ORF: 2478
• Locus ID: 8412
• Domains: SH2, RasGEF
• Protein Families: Druggable Genome
• Gene Summary: Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).