MAPK11 (NM_002751) Human Untagged Clone

CAT#: SC324181

MAPK11 (untagged)-Human mitogen-activated protein kinase 11 (MAPK11)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MAPK11
• Synonyms: p38-2; P38B; p38Beta; P38BETA2; PRKM11; SAPK2; SAPK2B
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002751.5 TCGGGCGCGGGCGCGGGGCGCGGGGCTGGGCCCGGGCGGAGCGGCGGCTGCTCCGGACAT
  GTCGGGCCCTCGCGCCGGCTTCTACCGGCAGGAGCTGAACAAGACCGTGTGGGAGGTGCC
  GCAGCGGCTGCAGGGGCTGCGCCCGGTGGGCTCCGGCGCCTACGGCTCCGTCTGTTCGGC
  CTACGACGCCCGGCTGCGCCAGAAGGTGGCGGTGAAGAAGCTGTCGCGCCCCTTCCAGTC
  GCTGATCCACGCGCGCAGAACGTACCGGGAGCTGCGGCTGCTCAAGCACCTGAAGCACGA
  GAACGTCATCGGGCTTCTGGACGTCTTCACGCCGGCCACGTCCATCGAGGACTTCAGCGA
  AGTGTACTTGGTGACCACCCTGATGGGCGCCGACCTGAACAACATCGTCAAGTGCCAGGC
  GCTGAGCGACGAGCACGTTCAATTCCTGGTTTACCAGCTGCTGCGCGGGCTGAAGTACAT
  CCACTCGGCCGGGATCATCCACCGGGACCTGAAGCCCAGCAACGTGGCTGTGAACGAGGA
  CTGTGAGCTCAGGATCCTGGATTTCGGGCTGGCGCGCCAGGCGGACGAGGAGATGACCGG
  CTATGTGGCCACGCGCTGGTACCGGGCACCTGAGATCATGCTCAACTGGATGCATTACAA
  CCAAACAGTGGATATCTGGTCCGTGGGCTGCATCATGGCTGAGCTGCTCCAGGGCAAGGC
  CCTCTTCCCGGGAAGCGACTACATTGACCAGCTGAAGCGCATCATGGAAGTGGTGGGCAC
  ACCCAGCCCTGAGGTTCTGGCAAAAATCTCCTCAGAACACGCCCGGACATATATCCAGTC
  CCTGCCCCCCATGCCCCAGAAGGACCTGAGCAGCATCTTCCGTGGAGCCAACCCCCTGGC
  CATAGACCTCCTTGGAAGGATGCTGGTGCTGGACAGTGACCAGAGGGTCAGTGCAGCTGA
  GGCACTGGCCCACGCCTACTTCAGCCAGTACCACGACCCCGAGGATGAGCCAGAGGCCGA
  GCCATATGATGAGAGCGTTGAGGCCAAGGAGCGCACGCTGGAGGAGTGGAAGGAGCTCAC
  TTACCAGGAAGTCCTCAGCTTCAAGCCCCCAGAGCCACCGAAGCCACCTGGCAGCCTGGA
  GATTGAGCAGTGAGGTGCTGCCCAGCAGCCCCTGAGAGCCTGTGGAGGGGCTTGGGCCTG
  CACCCTTCCACAGCTGGCCTGGTTTCCTCGAGAGGCACCTCCCACACTCCTATGGTCACA
  GACTTCTGGCCTAGGACCCCTCGCCTTCAGGAGAATCTACACGCATGTATGCATGCACAA
  ACATGTGTGTACATGTGCTTGCCATGTGTAGGAGTCTGGGCACAAGTGTCCCTGGGCCTA
  CCTTGGTCCTCCTGTCCTCTTCTGGCTACTGCACTCTCCACTGGGACCTGACTGTGGGGT
  CCTAGATGCCAAAGGGGTTCCCCTGCGGAGTTCCCCTGTCTGTCCCAGGCCGACCCAAGG
  GAGTGTCAGCCTTGGGCTCTCTTCTGTCCCAGGGCTTTCTGGAGGACGCGCTGGGGCCGG
  GACCCCGGGAGACTCAAAGGGAGAGGTCTCAGTGGTTAGAGCTGCTCAGCCTGGAGGTAG
  GGGGCTGTCTTGGTCACTGCTGAGACCCACAGGTCTAAGAGGAGAGGCAGAGCCAGTGTG
  CCACCAGGCTGGGCAGGGACAACCACCAGGTGTCAAATGAGAAAAGCTGCCTGGAGTCTT
  GTGTTCACCCGTGGGTGTGTGTGGGCACGTGTGGATGAGCGTGCACTCCCCGTGTTCATA
  TGTCAGGGCACATGTGATGTGGTGCGTGTGAATCTGTGGGCGCCCAAGGCCAGCAGCCAT
  ATCTGGCAAGAAGCTGGAGCCGGGGTGGGTGTGCTGTTGCCTTCCCTCTCCTCGGTTCCT
  GATGCCTTGAGGGGTGTTTCAGACTGGCGGCTCCAGTGGGCCAAAGGGCAACCACATGAG
  CATGGGCAGGGGCTTTCTCCTTGGATGTGGGACCCACAGCAGCTTCCTGAGGCTGGGGGT
  GGGTGGGTGGGTGGTTTGGCCTTGAGGACGCTAGGGCAGGCAGCACACCTGGATGTGGAC
  TTGGACTCGGACACTTCTGCCCTGCACCCTGGCCCGCTCTCTACCTCTGCCCACCGTTGT
  GGCCCTGCAGCCGGAGATCTGAGGTGCTCTGGTCTGTGGGTCAGTCCTCTTTCCTTGTCC
  CAGGATGGAGCTGATCCAGTAACCTCGGAGACGGGACCCTGCCCAGAGCTGAGTTGGGGG
  TGTGGCTCTGCCCTGGAAAGGGGGTGACCTCTTGCCTCGAGGGGCCCAGGGAAGCCTGGG
  TGTCAAGTGCCTGCACCAGGGGTGCACAATAAAGGGGGTTCTCTCTCAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAA
• Restriction Sites: ECoRI-NOT
• ACCN: NM_002751
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002751.5, NP_002742.3
• RefSeq Size: 2420 bp
• RefSeq ORF: 1095 bp
• Locus ID: 5600
• Cytogenetics: 22q13.33
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Amyotrophic lateral sclerosis (ALS), Epithelial cell signaling in Helicobacter pylori infection, Fc epsilon RI signaling pathway, GnRH signaling pathway, Leukocyte transendothelial migration, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, Toll-like receptor signaling pathway, VEGF signaling pathway
• Gene Summary: 'This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.