NEIL2 (NM_145043) Human Untagged Clone

CAT#: SC324496

NEIL2 (untagged)-Human nei endonuclease VIII-like 2 (E. coli) (NEIL2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NEIL2
• Synonyms: NEH2; NEI2
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_145043.1 TAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCG
  TTGGTGAGGAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACA
  GGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGTGGCTCCAGGACACC
  CAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCT
  GGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGAC
  CCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCA
  GAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGA
  GATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGAT
  TTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTG
  GTCCTGCACTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGC
  TCTTCCCCGGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCATCGAGGACAA
  GCCTTAGAAGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATAC
  TTCTCAGGGCTAGGGAACATCATTAAGAATGAAGCCTTGTACAGAGCTGGGATCCATCCC
  CTTTCTCTCGGTTCAGTCCTGAGTGCCTCGCGTCGGGAGGTCCTGGTGGATCACGTGGTG
  GAGTTCAGTACAGCCTGGCTGCAGGGCAAGTTCCAAGGCAGACCGCAGCACACACAGGTC
  TACCAGAAAGAACAGTGCCCTGCTGGCCACCAGGTCATGAAGGAGGCGTTTGGGCCCGAA
  GATGGGTTACAGAGGCTCACCTGGTGGTGCCCGCAGTGCCAGCCCCAGTTGTCAGAGGAG
  CCAGAGCAGTGCCAGTTCTCCTAAGGAGCTGGTGGTGCTCCTCATGGAACCTTGCCGTTG
  GGGAACCTGACGTCTAAGTGTCCAGAAAGGAGGATGTGGGCAGGGACGGGGTACAGAGGA
  TAGTGTGGGTCAGAGGTGCCAGTAGTATAATATTCATCTCCCTGGAGTTATGTTGAAGGC
  AGAGTTTTCATAGGGTTAGATTTTTTTTATCCTTTTCTAGTTCAGTTAATTCATCCTGTT
  GAATTGCACCATCGTGAAAGATGGGAAAAATCGTGATGATGGGTAAGGGGAAAACTTCCC
  GGAAGGCAATGGGGCAAGGAAAAAGAAAGCCTATGGGAAATGGCTGTGCTCCCAACATAG
  CTTTGCAGATGATGTGGGTTTTTTTTTTTTTTTTTTGGTTGTTTGTTTTGAGAGAGAGTC
  TTGCTCTGTCTCCCTGGCTAGGGTGTGGTGGTGTGATCTTGGCTCACGGCAGCCTTGCCC
  TCCCTGGCTCAAGCAGTCTTCATCTCAGCCTCCAGAGTAGCTGGGACTACAGGCATGTGA
  TATGATGCTCGGCTGATTTTTGTTTACTTTTTAGAGAGATGGGGTCTTGCCATATTTGCC
  AGGCTGGTTTGAACTCCTACAACTCAAGCATTCCTCCCACCTTGGTCTCCCAAAATGTTG
  GGACCACGGGTGTGAGCCACCGCGCCCAGCTAGCTCCTGTGTTTTGTTTTTGTTTTGTAA
  CTTTGGTTGATGTTAAGGCCCTCCATTTTGGAAAGCAGGAAAACAGGATTTTTTTTTTTT
  ATCTTGTTCCCTGGAGGATCCAGGGATGAGGATAGAGTGGCCTGAGAGCAGTGCTTGGAT
  TCAGCCTCCTGCTGGGTCCTTCTGCTGGATACAGGCACCAAGAGGCGGGGGTGGAGCAGG
  GAGCTGCGCCTTCCTGGGGTGCCCGGTGGTGTGTAGAGAAAAGCTGCTTGTTTACTCCTT
  AAGTCAATGTATTGGTGACTGTTGATTTGTTGAACAATTCAGGAATCAAGGGCTGTGGAG
  AAACTCCCTCATGTTGTTGGCAACAGGTGAATGAACCTAGAGCGGTGACATGAAAATAAA
  GCTCACTGTTACTCGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAAAAAAAAAAAAAAAA
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_145043.1 unedited
  GGCCAATTGTATACGACTCCTATAGGGCGGCCGGGGAACAAACGGCACGAGGTAGCGGTG
  CTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCGTTGGTGAG
  GAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAG
  CAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGTGGCTCCAGGACACCCAGGTCCA
  TGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAG
  CCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCA
  GGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGT
  CCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGG
  GAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAG
  AGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGGTTGGTCCTGCA
  CTTTGGTGGTGGTGGCTTCCTGGCATTTTATAATTGTCAGTTGTCTTGGAGCTCTTCCCC
  GGTGGTCACACCCACCTGTGACATCCTGTCTGAGAAGTTCCATCGAGGACAAGCCTTAGA
  AGCTCTAGGCCAGGCTCAGCCTGTCTGCTATACACTGCTGGACCAGAGATACTTTCTCAG
  GCTAGGGAACATCATTAAGATGAAGCCTTGTACAAGAGCTGGGATCCATCCCTTTCTCTC
  GGTTCAGTCCTGGATTGCCTCGCGTCGGGAGGTCTGGTGAATCAGTGGTGGAGTTCAGTC
  ACGCTGCTGCAGGGCAAGTTCCAGGCGAAATCG
• Restriction Sites: Please inquire
• ACCN: NM_145043
• ORF Size: 999 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_145043.1, NP_659480.1
• RefSeq Size: 2661
• RefSeq ORF: 999
• Locus ID: 252969
• Domains: Fapy_DNA_glyco
• Protein Families: Druggable Genome
• Protein Pathways: Base excision repair
• Gene Summary: This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 8 encode the same isoform (a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.