M6PR (NM_002355) Human Untagged Clone

CAT#: SC324560

M6PR (untagged)-Human mannose-6-phosphate receptor (cation dependent) (M6PR), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: M6PR
• Synonyms: CD-M6PR; CD-MPR; MPR-46; MPR 46; MPR46; SMPR
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002355.2 GGCACGAGGGAGTGGGGCACAGCGAGGCGCTAGGGGGAACGCTGGCCTCTGAAACTAGCT
  CTGGGACCGGGGTCTGCGGCCGGCCCCTAGCTGGCCCCGTCTCCCATCCCCAGAAGGGTA
  TTCACTGGGGATTCTGAGCTTTGGCTACTCCAGTTTCCCACGACACGATGTTCCCTTTCT
  ACAGCTGCTGGAGGACTGGACTGCTACTACTACTCCTGGCTGTGGCAGTGAGAGAATCCT
  GGCAGACAGAAGAAAAAACTTGCGACTTGGTAGGAGAAAAGGGTAAAGAGTCAGAGAAAG
  AGTTGGCTCTAGTGAAGAGGCTGAAACCACTGTTTAATAAAAGCTTTGAGAGCACTGTGG
  GCCAGGGTTCAGACACATACATCTACATCTTCAGGGTGTGCCGGGAAGCTGGCAACCACA
  CTTCTGGGGCAGGCCTGGTGCAAATCAACAAAAGTAATGGGAAGGAGACAGTGGTAGGGA
  GACTCAACGAGACTCACATCTTCAACGGAAGTAATTGGATCATGCTGATCTATAAAGGGG
  GTGATGAATATGACAACCACTGTGGCAAGGAGCAGCGTCGTGCAGTGGTGATGATCTCCT
  GCAATCGACACACCCTAGCGGACAATTTTAACCCTGTGTCTGAGGAGCGTGGCAAAGTCC
  AAGATTGTTTCTACCTCTTTGAGATGGATAGCAGCCTGGCCTGTTCACCAGAGATCTCCC
  ACCTCAGTGTGGGTTCCATCTTACTTGTCACGTTTGCATCACTGGTTGCTGTTTATGTTG
  TTGGGGGGTTCCTATACCAGCGACTGGTAGTGGGAGCCAAAGGAATGGAGCAGTTTCCCC
  ACTTAGCCTTCTGGCAGGATCTTGGCAACCTGGTAGCAGATGGCTGTGACTTTGTCTGCC
  GTTCTAAACCTCGAAATGTGCCTGCAGCATATCGTGGTGTGGGGGATGACCAGCTGGGGG
  AGGAGTCAGAAGAAAGGGATGACCATTTATTACCAATGTAGATTGCACTTTATATGTCCA
  GCCTCTTCCTCAGTCCCCCAAACCAAAGCTACACAGCCAGATTTCTCAAGCAGTCTCAAC
  TCCAGTCCCTCATCTCACCCTTACTATTGCTCTTGCTTTCCAGTTTGCTTTTGATTTGCA
  TCTTCTCACTAGTAAAACTGCCTTCCCTTTGTTCCTTATTTTCTGTTTTTTCTCTAGAGA
  GGTACAGTTGTAAGTCAGAGTTAATATAATAGGGCCTGTGAAAACAGAGGCTTTTGCATT
  GTCTCTTGACATCAGAAGTTACAATAGGCATATGGGCAAAATGGTGTAGCAGGCTCACTG
  GCCGTTTGTTTTTTAAACACATTTTCACAAGTTTTTGAGACACTGGATTTCTTTAATTAA
  AAAAAAAATGCCAAGAAACATTATTTATACAGGGTTGATTGCTTTCATGTTGTTATTCTG
  TACCCTATAGTAGCCTCCATGAGAATCTGGTATTTCTTGCTGCTTGGAACTACTTTGCAG
  TGATTACTTGGTTGCAGTCCAAGTACTCTCGTTTAGTCTGAGCCTGGAGATGTTCTAGAC
  TTGCTTCTCCCACCTCTGAGATTAGGACAGGAAAAATGTGAAATTTCCCAATTACAGGAT
  TATACGGTACCATCACATCATTTGTGGAAATTGGGGTGACTGTATAGCTGGGATTGGGCT
  AAGGACTGTGGTCTTATCTGTCCACATACAGCCAAAATGCCTATCCAGAAATCCAGTTCG
  TTGGAAAGGAAAATTGGTACTCCTGTGCCACAGGGGTTCCAGAAAAGGGAAGTCACTTTA
  CCTTGCGGTGGTGGGATCCTGATGTCTTTCATCCATTTGTAGTAAAAGCTGGTAAAGCTT
  TTCTTACTCCTGGTTCCCTACCAGTATTTCTAAACATGTCGCACTTTCTCCACAGGCATG
  TGGTTTTGACCTTTTTTTCAATCTTCTAGAAAGGGAACGGAAGCAGAAGTGGGACATCGA
  GGGCTCTGCTGTCCTCTGCGCTGGGTGTGGAATGCTGCTGCACCTGTCCCTTCTGCTGGC
  TCAGGGAAGTGTCTTCTTGCCCACATTTCTGTGGGGAAAGGTTTTTAATCCTCTGATGCT
  TCCATCTTCCTGTTTAGGCCATGTGCCCAGAAACCTGGACTGATCTTTCTTTAATAGTGA
  ACCCCTGGGCCACTGAAGAGTAACATGGCTCCACTGGACACAAAAGAGGGATGGAATCAA
  CAGGCAGGGGGCCTTTTATAAGCCTTAGGAAAAGAAAATGAAACTATTTCATCTTTGGAC
  TTTTCAATACTATTGGAGTGATTTTTTTTCTTTCTAAACAGGGAAAATAATGTTACAAAA
  GCATCTTTTTTGTTATTTGTTTGCATCCCTCCCCCACACCCTGGTGTTTTAAAATGAAGA
  AAAAAAACCATCACTTTTTGTACAAAAACTCTTAATGATTAAAAAACAAACAAAAAAAAA
  AAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_002355
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_002355.2, NP_002346.1
• RefSeq Size: 2454 bp
• RefSeq ORF: 834 bp
• Locus ID: 4074
• Cytogenetics: 12p13.31
• Domains: Man-6-P_recep
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome
• Gene Summary: 'This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]'
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).