Emi1 (FBXO5) (NM_001142522) Human Untagged Clone

CAT#: SC325052

FBXO5 (untagged)-Human F-box protein 5 (FBXO5), transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FBXO5
• Synonyms: EMI1; FBX5; Fbxo31
• Vector: pCMV6 series
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001142522, the custom clone sequence may differ by one or more nucleotides
  ATGAAGTGTGATTTTAATTGTAACCATGTTCATTCCGGACTTAAACTGGTAAAACCTGAT
  GACATTGGAAGACTAGTTTCCTACACCCCTGCATATTTGGAAGGTTCCTGTAAAGACTGC
  ATTAAAGACTATGAAAGGCTGTCATGTATTGGGTCACCGATTGTGAGCCCTAGGATTGTA
  CAACTTGAAACTGAAAGCAAGCGCTTGCATAACAAGGAAAATCAACATGTGCAACAGACA
  CTTAATAGTACAAATGAAATAGAAGCACTAGAGACCAGTAGACTTTATGAAGACAGTGGC
  TATTCCTCATTTTCTCTACAAAGTGGCCTCAGTGAACATGAAGAAGGTAGCCTCCTGGAG
  GAGAATTTCGGTGACAGTCTACAATCCTGCCTGCTACAAATACAAAGCCCAGACCAATAT
  CCCAACAAAAACTTGCTGCCAGTTCTTCATTTTGAAAAAGTGGTTTGTTCAACATTAAAA
  AAGAATGCAAAACGAAATCCTAAAGTAGATCGGGAGATGCTGAAGGAAATTATAGCCAGA
  GGAAATTTTAGACTGCAGAATATAATTGGCAGAAAAATGGGCCTAGAATGTGTAGATATT
  CTCAGCGAACTCTTTCGAAGGGGACTCAGACATGTCTTAGCAACTATTTTAGCACAACTC
  AGTGACATGGACTTAATCAATGTGTCTAAAGTGAGCACAACTTGGAAGAAGATCCTAGAA
  GATGATAAGGGGGCATTCCAGTTGTACAGTAAAGCAATACAAAGAGTTACCGAAAACAAC
  AATAAATTTTCACCTCATGCTTCAACCAGAGAATATGTTATGTTCAGAACCCCACTGGCT
  TCTGTTCAGAAATCAGCAGCCCAGACTTCTCTCAAAAAAGATGCTCAAACCAAGTTATCC
  AATCAAGGTGATCAGAAAGGTTCTACTTATAGTCGACACAATGAATTCTCTGAGGTTGCC
  AAGACATTGAAAAAGAACGAAAGCCTCAAAGCCTGTATTCGCTGTAATTCACCTGCAAAA
  TATGATTGCTATTTACAACGGGCAACCTGCAAACGAGAAGGCTGTGGATTTGATTATTGT
  ACGAAGTGTCTCTGTAATTATCATACTACTAAAGACTGTTCAGATGGCAAGCTCCTCAAA
  GCCAGTTGTAAAATAGGTCCCCTGCCTGGTACAAAGAAAAGCAAAAAGAATTTACGAAGA
  TTG
  
• Restriction Sites: Please inquire
• ACCN: NM_001142522
• ORF Size: 1206 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001142522.1, NP_001135994.1
• RefSeq Size: 2269
• RefSeq ORF: 1206
• Locus ID: 26271
• Protein Families: Druggable Genome
• Protein Pathways: Oocyte meiosis
• Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]
  Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.