NCOA4 (NM_001145262) Human Untagged Clone

CAT#: SC325235

NCOA4 (untagged)-Human nuclear receptor coactivator 4 (NCOA4), transcript variant 3

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: NCOA4
• Synonyms: ARA70; ELE1; PTC3; RFG
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001145262, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGAATACCTTCCAAGACCAGAGTGGCAGCTCCAGTAATAGAGAACCCCTTTTGAGGTGTAGTGATGCAC
  GGAGGGACTTGGAGCTTGCTATTGGTGGAGTTCTCCGGGCTGAACAGCAAATTAAAGATAACTTGCGAGA
  GGTCAAAGCTCAGATTCACAGTTGCATAAGCCGTCACCTGGAATGTCTTAGAAGCCGTGAGGTATGGCTG
  TATGAACAGGTGGACCTTATTTATCAGCTTAAAGAGGAGACACTTCAACAGCAGGCTCAGCAGCTCTACT
  CGTTATTGGGCCAGTTCAATTGTCTTACTCATCAACTGGAGTGTACCCAAAACAAAGATCTAGCCAATCA
  AGTCTCTGTGTGCCTGGAGAGACTGGGCAGTTTGACCCTTAAGCCTGAAGATTCAACTGTCCTGCTCTTT
  GAAGCTGACACAATTACTCTGCGCCAGACCATCACCACATTTGGGTCTCTCAAAACCATTCAAATTCCTG
  AGCACTTGATGGCTCATGCTAGTTCAGCAAATATTGGGCCCTTCCTGGAGAAGAGAGGCTGTATCTCCAT
  GCCAGAGCAGAAGTCAGCATCCGGTATTGTAGCTGTCCCTTTCAGCGAATGGCTCCTTGGAAGCAAACCT
  GCCAGTGGTTATCAAGCTCCTTACATACCCAGCACCGACCCCCAGGACTGGCTTACCCAAAAGCAGACCT
  TGGAGAACAGTCAGACTTCTTCCAGAGCCTGCAATTTCTTCAATAATGTCGGGGGAAACCTAAAGGGCTT
  AGAAAACTGGCTCCTCAAGAGTGAAAAATCAAGTTATCAAAAGTGTAACAGCCATTCCACTACTAGTTCT
  TTCTCCATTGAAATGGAAAAGGTTGGAGATCAAGAGCTTCCTGATCAAGATGAGATGGACCTATCAGATT
  GGCTAGTGACTCCCCAGGAATCCCATAAGCTGCGGAAGCCTGAGAATGGCAGTCGTGAAACCAGTGAGAA
  GTTTAAGCTCTTATTCCAGTCCTATAATGTGAATGATTGGCTTGTCAAGACTGACTCCTGTACCAACTGT
  CAGGGAAACCAGCCCAAAGGTGTGGAGATTGAAAACCTGGGCAATCTGAAGTGCCTGAATGACCACTTGG
  AGGCCAAGAAACCATTGTCCACCCCCAGCATGGTTACAGAGGATTGGCTTGTCCAGAACCATCAGGACCC
  ATGTAAGGTAGAGGAGGTGTGCAGAGCCAATGAGCCCTGCACAAGCTTTGCAGAGTGTGTGTGTGATGAG
  AATTGTGAGAAGGAGGCTCTGTATAAGTGGCTTCTGAAGAAAGAAGGAAAGGATAAAAATGGGATGCCTG
  TGGAACCCAAACCTGAGCCTGAGAAGCATAAAGATTCCCTGAATATGTGGCTCTGTCCTAGAAAAGAAGT
  AATAGAACAAACTAAAGCACCAAAGGCAATGACTCCTTCTAGAATTGCTGATTCCTTCCAAGTCATAAAG
  AACAGCCCCTTGTCGGAGTGGCTTATCAGGCCCCCATACAAAGAAGGAAGTCCCAAGGAAGTGCCTGGTA
  CTGAAGACAGAGCTGGCAAACAGAAGTTTAAAAGCCCCATGAATACTTCCTGGTGTTCCTTTAACACAGC
  TGACTGGGTCCTGCCAGGAAAGAAGATGGGCAACCTCAGCCAGTTATCTTCTGGAGAAGACAAGTGGCTG
  CTTCGAAAGAAGGCCCAGGAAGTATTACTTAATTCACCTCTACAGGAGGAACATAACTTCCCCCCAGACC
  ATTATGGCCTCCCTGCAGTTTGTGATCTCTTTGCCTGTATGCAGCTTAAAGTTGATAAAGAGAAGTGGTT
  ATATCGAACTCCTCTACAGATGTGA
  
  
• Restriction Sites: SgfI-MluI
• ACCN: NM_001145262
• ORF Size: 1845 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001145262.1, NP_001138734.1
• RefSeq Size: 3588
• RefSeq ORF: 1845
• Locus ID: 8031
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Pathways in cancer, Thyroid cancer
• Gene Summary: This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14. [provided by RefSeq, Feb 2009]
  Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG. This variant (3) also lacks an exon in the 3' coding region, which results in a frameshift and use of a downstream stop codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus and a shorter, distinct C-terminus compared to isoform 1. Variants 3, 4, and 5 encode the same protein.