ALIX (PDCD6IP) (NM_001162429) Human Untagged Clone

CAT#: SC327669

PDCD6IP (untagged)-Human programmed cell death 6 interacting protein (PDCD6IP) transcript variant 2

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: PDCD6IP
• Synonyms: AIP1; ALIX; DRIP4; HP95
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001162429, the custom clone sequence may differ by one or more nucleotides
  ATGGCGACATTCATCTCGGTGCAGCTGAAAAAGACCTCAGAGGTGGACCTGGCCAAGCCG
  CTGGTGAAGTTCATCCAGCAGACTTACCCAAGCGGCGGGGAAGAGCAGGCCCAGTACTGC
  CGCGCGGCGGAGGAGCTCAGCAAGCTGCGCCGCGCCGCAGTCGGTCGTCCGCTGGACAAG
  CACGAGGGCGCGCTCGAGACGCTCCTGAGATATTATGATCAGATTTGTTCTATTGAACCC
  AAATTCCCATTTTCTGAAAATCAGATCTGCTTGACATTTACCTGGAAGGATGCTTTCGAT
  AAAGGTTCACTTTTTGGAGGCTCTGTAAAACTGGCTCTTGCAAGCTTAGGATATGAAAAG
  AGCTGTGTGTTGTTCAATTGTGCAGCCTTAGCTAGCCAAATTGCAGCAGAACAGAACCTG
  GATAATGATGAAGGATTGAAAATCGCTGCTAAACATTACCAGTTTGCTAGTGGTGCCTTT
  TTACATATTAAAGAGACGGTTTTATCTGCCTTAAGTCGAGAGCCGACCGTGGACATATCT
  CCAGATACTGTTGGGACCCTCAGTCTTATTATGCTGGCACAGGCTCAAGAAGTATTTTTT
  TTAAAAGCCACAAGAGATAAAATGAAAGATGCCATCATAGCTAAATTGGCTAATCAGGCT
  GCAGATTATTTTGGTGATGCTTTCAAACAGTGTCAATACAAAGATACTCTCCCCAAGTAT
  TTTTATTTCCAGGAGGTGTTCCCTGTCTTGGCTGCAAAGCACTGTATCATGCAGGCCAAT
  GCTGAGTACCATCAGTCTATCCTGGCAAAACAGCAGAAGAAATTTGGAGAAGAAATTGCA
  AGGTTACAGCATGCAGCAGAACTGATTAAAACAGTGGCATCTCGCTATGATGAATATGTT
  AATGTGAAGGATTTTTCTGACAAAATCAATCGTGCCCTTGCTGCAGCAAAGAAGGATAAT
  GACTTCATTTATCATGATCGAGTTCCAGACCTTAAAGATCTAGATCCTATTGGCAAAGCC
  ACACTTGTGAAATCTACCCCGGTCAATGTACCCATCAGTCAGAAATTTACTGATCTGTTT
  GAGAAGATGGTTCCCGTGTCAGTACAGCAGTCTTTGGCTGCCTATAATCAGAGGAAAGCC
  GATTTGGTTAACAGATCAATTGCTCAGATGAGAGAAGCCACCACTTTGGCAAATGGGGTG
  CTAGCTTCCCTTAATCTTCCAGCAGCAATTGAAGATGTGTCTGGAGACACTGTACCTCAG
  TCTATATTGACTAAATCCAGATCTGTGATTGAACAGGGAGGCATCCAGACTGTTGATCAG
  TTGATTAAAGAACTGCCTGAATTACTGCAACGAAATAGAGAAATCCTAGATGAGTCATTA
  AGGTTGTTGGATGAAGAAGAAGCAACCGATAATGATTTAAGAGCAAAATTTAAGGAACGT
  TGGCAAAGGACACCATCCAATGAACTGTATAAGCCTTTAAGAGCAGAGGGAACCAACTTC
  AGAACAGTTTTAGATAAAGCTGTGCAGGCAGATGGACAAGTGAAAGAATGTTACCAGTCT
  CATCGTGACACCATCGTGCTTTTGTGTAAGCCAGAGCCTGAGCTGAATGCTGCCATCCCT
  TCTGCTAATCCAGCAAAGACCATGCAGGGCAGTGAGGTTGTAAATGTCTTAAAATCCTTA
  TTGTCAAATCTTGATGAAGTAAAGAAGGAAAGAGAGGGTCTGGAGAATGACTTGAAATCT
  GTGAATTTTGACATGACAAGCAAGTTTTTGACAGCCCTGGCTCAAGATGGTGTGATAAAT
  GAAGAAGCTCTTTCTGTTACTGAACTAGATCGAGTCTATGGAGGTCTTACAACTAAAGTC
  CAAGAATCTCTAAAGAAACAGGAGGGACTTCTTAAAAATATTCAGGTCTCACATCAGGAA
  TTTTCAAAAATGAAACAATCTAATAATGAAGCTAACTTAAGAGAAGAAGTTTTGAAGAAT
  TTAGCTACTGCATATGACAACTTTGTTGAACTTGTAGCTAATTTGAAGGAAGGCACAAAG
  TTTTACAATGAGTTGACTGAAATCCTGGTCAGGTTCCAGAACAAATGCAGTGATATAGTT
  TTTGCACGGAAGACAGAAAGAGATGAACTCTTAAAGGACTTGCAACAAAGCATTGCCAGA
  GAACCTAGTGCTCCTTCAATTCCTACACCTGCGTATCAGTCCTCACCAGCAGGAGGACAT
  GCACCAACTCCTCCAACTCCAGCGCCAAGAACCATGCCGCCTACTAAGCCCCAGCCCCCA
  GCCAGGCCTCCACCACCTGTGCTTCCAGCAAATCGAGCTCCTTCTGCTACTGCTCCATCT
  CCAGTGGGGGCTGGGACTGCTGCGCCAGCTCCATCACAAACGCCTGGCTCAGCTCCTCCT
  CCACAGGCGCAGGGACCACCCTATCCCACCTATCCAGGATATCCTGGGTATTGCCAAATG
  CCCATGCCCATGGGCTATAATCCTTATGCGTATGGCCAGTATAATATGCCATATCCACCA
  GTGTATCACCAGAGTCCTGGACAGGCTCCATACCCGGGACCCCAGCAGCCTTCATACCCC
  TTCCCTCAGCCCCCACAGCAGTCTTACTATCCACAGCAG
  
• Restriction Sites: Please inquire
• ACCN: NM_001162429
• ORF Size: 2622 bp
• Insert Size: 5987
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.

Reference Data

• RefSeq: NM_001162429.1, NP_001155901.1
• RefSeq Size: 5987
• RefSeq ORF: 2622
• Locus ID: 10015
• Protein Families: Druggable Genome
• Protein Pathways: Endocytosis
• Gene Summary: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
  Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).